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Twelve osteoporotic female beagles were subjected to implant surgeries and assigned to one of three groups: control, rhPTH(1-34), or dimeric\n                    <jats:sup>R25C<\/jats:sup>\n                    PTH(1-34). Bone regeneration and osseointegration were evaluated after 10 weeks using micro-computed tomographic (micro-CT), histological analyses, and serum biochemical assays. Results showed that the rhPTH(1-34) group demonstrated superior improvements in bone mineral density, trabecular architecture, and osseointegration compared to controls, while the dimeric\n                    <jats:sup>R25C<\/jats:sup>\n                    PTH(1-34) group exhibited similar, though slightly less pronounced, anabolic effects. Histological and TRAP assays indicated both PTH analogs significantly enhanced bone regeneration, especially in artificially created bone defects. The findings suggest that both rhPTH(1-34) and dimeric\n                    <jats:sup>R25C<\/jats:sup>\n                    PTH(1-34) hold potential as therapeutic agents for promoting bone regeneration and improving osseointegration around implants in osteoporotic conditions, with implications for their use in bone-related pathologies and reconstructive surgeries.\n                  <\/jats:p>","DOI":"10.7554\/elife.93830","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T14:25:13Z","timestamp":1709130313000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.93830","source":"Crossref","is-referenced-by-count":7,"title":["Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model"],"prefix":"10.7554","volume":"13","author":[{"given":"Jeong-Oh","family":"Shin","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03qjsrb10","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Anatomy, Soonchunhyang University College of Medicine","place":["Cheonan, Republic of 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