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Sloan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000879","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The University of Chicago Institute for Neuroscience startup funds"},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32DA043469"],"award-info":[{"award-number":["T32DA043469"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Neuromodulatory inputs to the hippocampus play pivotal roles in modulating synaptic plasticity, shaping neuronal activity, and influencing learning and memory. Recently, it has been shown that the main sources of catecholamines to the hippocampus, ventral tegmental area (VTA) and locus coeruleus (LC), may have overlapping release of neurotransmitters and effects on the hippocampus. Therefore, to dissect the impacts of both VTA and LC circuits on hippocampal function, a thorough examination of how these pathways might differentially operate during behavior and learning is necessary. We therefore utilized two-photon microscopy to functionally image the activity of VTA and LC axons within the CA1 region of the dorsal hippocampus in head-fixed male mice navigating linear paths within virtual reality (VR) environments. We found that within familiar environments some VTA axons and the vast majority of LC axons showed a correlation with the animals\u2019 running speed. However, as mice approached previously learned rewarded locations, a large majority of VTA axons exhibited a gradual ramping-up of activity, peaking at the reward location. In contrast, LC axons displayed a pre-movement signal predictive of the animal\u2019s transition from immobility to movement. Interestingly, a marked divergence emerged following a switch from the familiar to novel VR environments. Many LC axons showed large increases in activity that remained elevated for over a minute, while the previously observed VTA axon ramping-to-reward dynamics disappeared during the same period. In conclusion, these findings highlight distinct roles of VTA and LC catecholaminergic inputs in the dorsal CA1 hippocampal region. These inputs encode unique information, with reward information in VTA inputs and novelty and kinematic information in LC inputs, likely contributing to differential modulation of hippocampal activity during behavior and learning.<\/jats:p>","DOI":"10.7554\/elife.95213","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T11:25:48Z","timestamp":1708946748000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.95213","source":"Crossref","is-referenced-by-count":9,"title":["Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4527-0405","authenticated-orcid":true,"given":"Chad","family":"Heer","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024mw5h28","id-type":"ROR","asserted-by":"publisher"}],"name":"The Department of Neurobiology, The University of Chicago","place":["Chicago, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0969-7820","authenticated-orcid":true,"given":"Mark","family":"Sheffield","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024mw5h28","id-type":"ROR","asserted-by":"publisher"}],"name":"The Department of Neurobiology, The University of Chicago","place":["Chicago, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.neuroscience.2020.06.045","type":"journal-article","article-title":"Distribution of VTA glutamate and dopamine terminals, and their significance in CA1 neural network activity","volume":"446","author":"Adeniyi","year":"2020","journal-title":"Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2023.107760","type":"journal-article","article-title":"VTA multifaceted modulation of CA1 local circuits","volume":"202","author":"Adeyelu","year":"2023","journal-title":"Neurobiology of Learning and Memory"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2015.00125","type":"journal-article","article-title":"Beta-adrenergic receptors support attention to extinction learning that occurs in the absence, but not the presence, of a context change","volume":"9","author":"Andr\u00e9","year":"2015","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.neuron.2014.08.042","type":"journal-article","article-title":"Engagement of neural circuits underlying 2D spatial navigation in a rodent virtual reality system","volume":"84","author":"Aronov","year":"2014","journal-title":"Neuron"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1523\/JNEUROSCI.01-08-00887.1981","type":"journal-article","article-title":"Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli","volume":"1","author":"Aston-Jones","year":"1981","journal-title":"The Journal of Neuroscience"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/s0165-0173(03)00143-7","type":"journal-article","article-title":"The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes","volume":"42","author":"Berridge","year":"2003","journal-title":"Brain Research. 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