{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:19:53Z","timestamp":1788891593665,"version":"build-2803163510"},"reference-count":93,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018128","name":"Ludwig Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018128","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Oncology Core CA","award":["06973"],"award-info":[{"award-number":["06973"]}]},{"DOI":"10.13039\/100016295","name":"Sol Goldman Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016295","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NCI Cancer Center Support Grant","award":["P30 CA006973"],"award-info":[{"award-number":["P30 CA006973"]}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA270403"],"award-info":[{"award-number":["K08CA270403"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["Translation Research Program Award"],"award-info":[{"award-number":["Translation Research Program Award"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","award":["Scholar Award"],"award-info":[{"award-number":["Scholar Award"]}],"id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016947","name":"Swim Across America","doi-asserted-by":"publisher","award":["Translational Cancer Research Award"],"award-info":[{"award-number":["Translational Cancer Research Award"]}],"id":[{"id":"10.13039\/100016947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Despite exciting developments in cancer immunotherapy, its broad application is limited by the paucity of targetable antigens on the tumor cell surface. As an intrinsic cellular pathway, nonsense-mediated decay (NMD) conceals neoantigens through the destruction of the RNA products from genes harboring truncating mutations. We developed and conducted a high-throughput screen, based on the ratiometric analysis of transcripts, to identify critical mediators of NMD in human cells. This screen implicated disruption of kinase SMG1\u2019s phosphorylation of UPF1 as a potential disruptor of NMD. This led us to design a novel SMG1 inhibitor, KVS0001, that elevates the expression of transcripts and proteins resulting from human and murine truncating mutations in vitro and murine cells in vivo. Most importantly, KVS0001 concomitantly increased the presentation of immune-targetable human leukocyte antigens (HLA) class I-associated peptides from NMD-downregulated proteins on the surface of human cancer cells. KVS0001 provides new opportunities for studying NMD and the diseases in which NMD plays a role, including cancer and inherited diseases.<\/jats:p>","DOI":"10.7554\/elife.95952","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T13:26:12Z","timestamp":1715088372000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.95952","source":"Crossref","is-referenced-by-count":16,"title":["Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-5732","authenticated-orcid":true,"given":"Ashley L","family":"Cook","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4536-7343","authenticated-orcid":true,"given":"Surojit","family":"Sur","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Laura","family":"Dobbyn","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Evangeline","family":"Watson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Joshua D","family":"Cohen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"software","vocabulary":"credit"}]},{"given":"Blair","family":"Ptak","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Bum Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Suman","family":"Paul","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Emily","family":"Hsiue","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Maria","family":"Popoli","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Bert","family":"Vogelstein","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/006w34k90","id-type":"ROR","asserted-by":"publisher"}],"name":"Howard Hughes Medical Institute, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Nickolas","family":"Papadopoulos","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9991-7123","authenticated-orcid":true,"given":"Chetan","family":"Bettegowda","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Kathy","family":"Gabrielson","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Shibin","family":"Zhou","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Kenneth W","family":"Kinzler","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4252-4470","authenticated-orcid":true,"given":"Nicolas","family":"Wyhs","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]},{"name":"Department of Oncology, Johns Hopkins Medical Institutions","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine","place":["Baltimore, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102389","type":"journal-article","article-title":"NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes","volume":"24","author":"Becker","year":"2021","journal-title":"iScience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1001\/jamaoncol.2017.4445","type":"journal-article","article-title":"Association of immunotherapy with durable survival as defined by value frameworks for cancer care","volume":"4","author":"Ben-Aharon","year":"2018","journal-title":"JAMA Oncology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1158\/1078-0432.CCR-17-3421","type":"journal-article","article-title":"A first-in-human phase 1 study of LY3023414, an oral PI3K\/mTOR dual inhibitor, in patients with advanced cancer","volume":"24","author":"Bendell","year":"2018","journal-title":"Clinical Cancer Research"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.15252\/emmm.201404461","type":"journal-article","article-title":"5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion","volume":"6","author":"Bhuvanagiri","year":"2014","journal-title":"EMBO Molecular Medicine"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02192-2","type":"journal-article","article-title":"Deciphering the nonsense-mediated mRNA decay pathway to identify cancer cell vulnerabilities for effective cancer therapy","volume":"40","author":"Bongiorno","year":"2021","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"625","DOI":"10.5483\/BMBRep.2023-0190","type":"journal-article","article-title":"Nonsense-mediated mRNA decay, a simplified view of a complex mechanism","volume":"56","author":"Carrard","year":"2023","journal-title":"BMB Reports"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"28995","DOI":"10.1074\/jbc.270.48.28995","type":"journal-article","article-title":"A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro","volume":"270","author":"Carter","year":"1995","journal-title":"The Journal of Biological Chemistry"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-190","type":"journal-article","article-title":"Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma","volume":"15","author":"Castle","year":"2014","journal-title":"BMC Genomics"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1093\/annonc\/mdy495","type":"journal-article","article-title":"Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic","volume":"30","author":"Chan","year":"2019","journal-title":"Annals of Oncology"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204978","type":"journal-article","article-title":"Compound C inhibits nonsense-mediated RNA decay independently of AMPK","volume":"13","author":"Cheruiyot","year":"2018","journal-title":"PLOS ONE"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"4499","DOI":"10.1158\/0008-5472.CAN-20-4016","type":"journal-article","article-title":"Nonsense-Mediated RNA decay is a unique vulnerability of cancer cells harboring SF3B1 or U2AF1 Mutations","volume":"81","author":"Cheruiyot","year":"2021","journal-title":"Cancer Research"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104437","type":"journal-article","article-title":"An isogenic cell line panel for sequence-based screening of targeted anticancer drugs","volume":"25","author":"Cook","year":"2022","journal-title":"iScience"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17283-4","type":"journal-article","article-title":"Identification of nonsense-mediated mRNA decay pathway as a critical regulator of p53 isoform \u03b2","volume":"7","author":"Cowen","year":"2017","journal-title":"Scientific Reports"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"4708","DOI":"10.1172\/JCI125022","type":"journal-article","article-title":"Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation","volume":"129","author":"Dalton","year":"2019","journal-title":"The Journal of Clinical Investigation"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0191-1","type":"journal-article","article-title":"Immune checkpoint inhibitors: recent progress and potential biomarkers","volume":"50","author":"Darvin","year":"2018","journal-title":"Experimental & Molecular Medicine"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1083\/jcb.200611086","type":"journal-article","article-title":"Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies","volume":"178","author":"Durand","year":"2007","journal-title":"The Journal of Cell Biology"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.044891","type":"journal-article","article-title":"A regulated NMD mouse model supports NMD inhibition as A viable therapeutic option to treat genetic diseases","volume":"13","author":"Echols","year":"2020","journal-title":"Disease Models & Mechanisms"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","type":"journal-article","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"European Journal of Cancer"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1093\/hmg\/8.10.1893","type":"journal-article","article-title":"Nonsense-mediated mRNA decay in health and disease","volume":"8","author":"Frischmeyer","year":"1999","journal-title":"Human Molecular Genetics"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"6636","DOI":"10.1016\/j.bmcl.2012.08.107","type":"journal-article","article-title":"Identification of pyrimidine derivatives as hSMG-1 inhibitors","volume":"22","author":"Gopalsamy","year":"2012","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1039\/c5ob02482j","type":"journal-article","article-title":"Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay","volume":"14","author":"Gotham","year":"2016","journal-title":"Organic & Biomolecular Chemistry"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI154945","type":"journal-article","article-title":"Next-generation sequencing: unraveling genetic mechanisms that shape cancer immunotherapy efficacy","volume":"132","author":"Halima","year":"2022","journal-title":"The Journal of Clinical Investigation"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.2535","type":"journal-article","article-title":"Estimation of the percentage of US patients with cancer who are eligible for and respond to checkpoint inhibitor immunotherapy drugs","volume":"2","author":"Haslam","year":"2019","journal-title":"JAMA Network Open"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc8697","type":"journal-article","article-title":"Targeting a neoantigen derived from a common TP53 mutation","volume":"371","author":"Hsiue","year":"2021","journal-title":"Science"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15943","type":"journal-article","article-title":"A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay","volume":"8","author":"Hu","year":"2017","journal-title":"Nature Communications"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022410118","type":"journal-article","article-title":"Targeting loss of heterozygosity for cancer-specific immunotherapy","volume":"118","author":"Hwang","year":"2021","journal-title":"PNAS"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","type":"journal-article","article-title":"Pan-cancer analysis of whole genomes","volume":"578","author":"ICGC\/TCGA Pan-Cancer Analysis of Whole Genomes Consortium","year":"2020","journal-title":"Nature"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060478","type":"journal-article","article-title":"Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression","volume":"8","author":"Keeling","year":"2013","journal-title":"PLOS ONE"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1165\/rcmb.2018-0316OC","type":"journal-article","article-title":"Nonsense-mediated RNA decay pathway inhibition restores expression and function of W1282X CFTR","volume":"61","author":"Keenan","year":"2019","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","type":"journal-article","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nature Biotechnology"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/nbt.3080","type":"journal-article","article-title":"A comprehensive transcriptional portrait of human cancer cell lines","volume":"33","author":"Klijn","year":"2015","journal-title":"Nature Biotechnology"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1101\/gr.129684.111","type":"journal-article","article-title":"VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing","volume":"22","author":"Koboldt","year":"2012","journal-title":"Genome Research"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41571-021-00552-7","type":"journal-article","article-title":"Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways","volume":"19","author":"Kraehenbuehl","year":"2022","journal-title":"Nature Reviews. Clinical Oncology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/s41580-019-0126-2","type":"journal-article","article-title":"Quality and quantity control of gene expression by nonsense-mediated mRNA decay","volume":"20","author":"Kurosaki","year":"2019","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib35","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.72353","type":"journal-article","article-title":"Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8","volume":"10","author":"Langer","year":"2021","journal-title":"eLife"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1038\/sj.ejhg.5201889","type":"journal-article","article-title":"The efficiency of nonsense-mediated mRNA decay is an inherent character and varies among different cells","volume":"15","author":"Linde","year":"2007","journal-title":"European Journal of Human Genetics"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/ng.3664","type":"journal-article","article-title":"The rules and impact of nonsense-mediated mRNA decay in human cancers","volume":"48","author":"Lindeboom","year":"2016","journal-title":"Nature Genetics"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1038\/s41588-019-0517-5","type":"journal-article","article-title":"The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy","volume":"51","author":"Lindeboom","year":"2019","journal-title":"Nature Genetics"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"4032","DOI":"10.1016\/j.cell.2021.05.038","type":"journal-article","article-title":"Pharmacologic modulation of RNA splicing enhances anti-tumor immunity","volume":"184","author":"Lu","year":"2021","journal-title":"Cell"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/s41588-022-01108-w","type":"journal-article","article-title":"Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity","volume":"54","author":"Ma","year":"2022","journal-title":"Nature Genetics"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1126\/science.1215040","type":"journal-article","article-title":"A systematic survey of loss-of-function variants in human protein-coding genes","volume":"335","author":"MacArthur","year":"2012","journal-title":"Science"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"7021","DOI":"10.1073\/pnas.92.15.7021","type":"journal-article","article-title":"A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity","volume":"92","author":"Mack","year":"1995","journal-title":"PNAS"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1126\/science.aau0447","type":"journal-article","article-title":"Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response","volume":"364","author":"Mandal","year":"2019","journal-title":"Science"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1158\/0008-5472.CAN-13-2235","type":"journal-article","article-title":"Identification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutations","volume":"74","author":"Martin","year":"2014","journal-title":"Cancer Research"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1002\/1097-0142(197305)31:5<1170::aid-cncr2820310520>3.0.co;2-4","type":"journal-article","article-title":"A phase I study of emetine hydrochloride (NSC 33669) in solid tumors","volume":"31","author":"Mastrangelo","year":"1973","journal-title":"Cancer"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"12186","DOI":"10.1073\/pnas.1007336107","type":"journal-article","article-title":"Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay","volume":"107","author":"McIlwain","year":"2010","journal-title":"PNAS"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/ng1429","type":"journal-article","article-title":"Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise","volume":"36","author":"Mendell","year":"2004","journal-title":"Nature Genetics"},{"key":"bib48","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13020287","type":"journal-article","article-title":"Overcoming challenges for CD3-bispecific antibody therapy in solid tumors","volume":"13","author":"Middelburg","year":"2021","journal-title":"Cancers"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.mrrev.2014.05.001","type":"journal-article","article-title":"Nonsense-mediated decay in genetic disease: friend or foe?","volume":"762","author":"Miller","year":"2014","journal-title":"Mutation Research. Reviews in Mutation Research"},{"key":"bib50","first-page":"229","type":"journal-article","article-title":"Treatment of advanced gastrointestinal cancer with ememtine (NSC-33669)","volume":"58","author":"Moertel","year":"1974","journal-title":"Cancer Chemotherapy Reports"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1093\/hmg\/ddt035","type":"journal-article","article-title":"Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders","volume":"22","author":"Nguyen","year":"2013","journal-title":"Human Molecular Genetics"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.neubiorev.2013.10.016","type":"journal-article","article-title":"Nonsense-mediated mRNA decay: inter-individual variability and human disease","volume":"46 Pt 2","author":"Nguyen","year":"2014","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"bib53","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01364-0","type":"journal-article","article-title":"Nonsense-mediated RNA decay and its bipolar function in cancer","volume":"20","author":"Nogueira","year":"2021","journal-title":"Molecular Cancer"},{"key":"bib54","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-020-02240-8","type":"journal-article","article-title":"Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer","volume":"22","author":"Oka","year":"2021","journal-title":"Genome Biology"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nature08999","type":"journal-article","article-title":"Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay","volume":"465","author":"Pastor","year":"2010","journal-title":"Nature"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.chembiol.2011.04.011","type":"journal-article","article-title":"In situ kinase profiling reveals functionally relevant properties of native kinases","volume":"18","author":"Patricelli","year":"2011","journal-title":"Chemistry & Biology"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1038\/nprot.2016.095","type":"journal-article","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nature Protocols"},{"key":"bib58","type":"software","article-title":"R: A language and environment for statistical computing","author":"R Development Core Team","year":"2022","unstructured":"R Development Core Team. 2022. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. 2.6.2. https:\/\/www.R-project.org."},{"key":"bib59","doi-asserted-by":"publisher","first-page":"W449","DOI":"10.1093\/nar\/gkaa379","type":"journal-article","article-title":"NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data","volume":"48","author":"Reynisson","year":"2020","journal-title":"Nucleic Acids Research"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1126\/science.aar4060","type":"journal-article","article-title":"Cancer immunotherapy using checkpoint blockade","volume":"359","author":"Ribas","year":"2018","journal-title":"Science"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1126\/science.aaa1348","type":"journal-article","article-title":"Cancer immunology: mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer","volume":"348","author":"Rizvi","year":"2015","journal-title":"Science"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nbt.1754","type":"journal-article","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nature Biotechnology"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1002\/cncr.32677","type":"journal-article","article-title":"Phase 2 study of LY3023414 in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway","volume":"126","author":"Rubinstein","year":"2020","journal-title":"Cancer"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1042\/BA20080266","type":"journal-article","article-title":"Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassaemia mutation for the screening of correctors of stop-codon mutations","volume":"54","author":"Salvatori","year":"2009","journal-title":"Biotechnology and Applied Biochemistry"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/s41588-018-0312-8","type":"journal-article","article-title":"Tumor mutational load predicts survival after immunotherapy across multiple cancer types","volume":"51","author":"Samstein","year":"2019","journal-title":"Nature Genetics"},{"key":"bib66","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100194","type":"journal-article","article-title":"Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting","volume":"2","author":"Schmidt","year":"2021","journal-title":"Cell Reports. Medicine"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1158\/0008-5472.CAN-07-3095","type":"journal-article","article-title":"Epitope landscape in breast and colorectal cancer","volume":"68","author":"Segal","year":"2008","journal-title":"Cancer Research"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"e143","DOI":"10.1016\/S1470-2045(17)30074-8","type":"journal-article","article-title":"iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics","volume":"18","author":"Seymour","year":"2017","journal-title":"The Lancet. Oncology"},{"key":"bib69","first-page":"423","type":"journal-article","article-title":"Phase II study of emetine (NSC-33669) in the treatment of solid tumors","volume":"57","author":"Siddiqui","year":"1973","journal-title":"Cancer Chemotherapy Reports"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"9967","DOI":"10.1073\/pnas.1511996112","type":"journal-article","article-title":"Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes","volume":"112","author":"Skora","year":"2015","journal-title":"PNAS"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1158\/1535-7163.MCT-15-0996","type":"journal-article","article-title":"Characterization of LY3023414, a Novel PI3K\/mTOR dual inhibitor eliciting transient target modulation to impede tumor growth","volume":"15","author":"Smith","year":"2016","journal-title":"Molecular Cancer Therapeutics"},{"key":"bib72","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-023-03004-w","type":"journal-article","article-title":"Mapping genetic variants for nonsense-mediated mRNA decay regulation across human tissues","volume":"24","author":"Sun","year":"2023","journal-title":"Genome Biology"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1158\/1078-0432.CCR-21-2326","type":"journal-article","article-title":"Phase Ib\/II study of enzalutamide with samotolisib (ly3023414) or placebo in patients with metastatic castration-resistant prostate cancer","volume":"28","author":"Sweeney","year":"2022","journal-title":"Clinical Cancer Research"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2011.10.001","type":"journal-article","article-title":"In vivo toxicological evaluation of anisomycin","volume":"208","author":"Tang","year":"2012","journal-title":"Toxicology Letters"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/ng2100","type":"journal-article","article-title":"Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation","volume":"39","author":"Tarpey","year":"2007","journal-title":"Nature Genetics"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/S1470-2045(17)30516-8","type":"journal-article","article-title":"Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis","volume":"18","author":"Turajlic","year":"2017","journal-title":"The Lancet. Oncology"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.jcf.2018.12.001","type":"journal-article","article-title":"Isogenic cell models of cystic fibrosis-causing variants in natively expressing pulmonary epithelial cells","volume":"18","author":"Valley","year":"2019","journal-title":"Journal of Cystic Fibrosis"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1126\/science.aad0095","type":"journal-article","article-title":"Genomic correlates of response to CTLA-4 blockade in metastatic melanoma","volume":"350","author":"Van Allen","year":"2015","journal-title":"Science"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1126\/science.1235122","type":"journal-article","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1158\/2326-6066.CIR-19-0107","type":"journal-article","article-title":"Direct detection and quantification of neoantigens","volume":"7","author":"Wang","year":"2019","journal-title":"Cancer Immunology Research"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"76374","DOI":"10.18632\/oncotarget.13062","type":"journal-article","article-title":"Genomic profiling is predictive of response to cisplatin treatment but not to PI3K inhibition in bladder cancer patient-derived xenografts","volume":"7","author":"Wei","year":"2016","journal-title":"Oncotarget"},{"key":"bib82","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4","type":"book","volume-title":"Ggplot 2 3.5.1","author":"Wickham","year":"2016"},{"key":"bib83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016012","type":"journal-article","article-title":"Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability","volume":"5","author":"Williams","year":"2010","journal-title":"PLOS ONE"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1101\/gad.913001","type":"journal-article","article-title":"Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay","volume":"15","author":"Yamashita","year":"2001","journal-title":"Genes & Development"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/gtc.12033","type":"journal-article","article-title":"Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay","volume":"18","author":"Yamashita","year":"2013","journal-title":"Genes to Cells"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/s41571-023-00789-4","type":"journal-article","article-title":"Antigen presentation in cancer - mechanisms and clinical implications for immunotherapy","volume":"20","author":"Yang","year":"2023","journal-title":"Nature Reviews. Clinical Oncology"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1056\/NEJMc1713444","type":"journal-article","article-title":"Tumor mutational burden and response rate to PD-1 inhibition","volume":"377","author":"Yarchoan","year":"2017","journal-title":"The New England Journal of Medicine"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.omtn.2021.12.003","type":"journal-article","article-title":"Molecular profiling of individual FDA-approved clinical drugs identifies modulators of nonsense-mediated mRNA decay","volume":"27","author":"Zhao","year":"2022","journal-title":"Molecular Therapy. Nucleic Acids"},{"key":"bib89","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/s41422-019-0255-3","type":"journal-article","article-title":"Cryo-EM structure of SMG1\u2013SMG8\u2013SMG9 complex","volume":"29","author":"Zhu","year":"2019","journal-title":"Cell Research"},{"key":"bib90","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.bbrc.2017.06.052","type":"journal-article","article-title":"Targeting PI3K-AKT-mTOR by LY3023414 inhibits human skin squamous cell carcinoma cell growth in vitro and in vivo","volume":"490","author":"Zou","year":"2017","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"dataset1","doi-asserted-by":"publisher","DOI":"10.17632\/pyzxxvjphk.4","type":"dataset","article-title":"NMD Paper Full Westerns","volume-title":"Mendeley Data","author":"Wyhs","year":"2024","unstructured":"Wyhs N. 2024. NMD Paper Full Westerns. Mendeley Data."},{"key":"dataset2","doi-asserted-by":"publisher","DOI":"10.5061\/dryad.69p8cz9dj","type":"dataset","article-title":"RNA-seq data for LS180 and NCI-H358 Cancer Cell Lines","volume-title":"Dryad Digital Repository","author":"Wyhs","year":"2025","unstructured":"Wyhs N. 2025. RNA-seq data for LS180 and NCI-H358 Cancer Cell Lines. Dryad Digital Repository."},{"key":"dataset3","type":"dataset","article-title":"TSGKO_RNASeq","volume-title":"European Genome-Phenome Archive","author":"Cook","year":"2022","unstructured":"Cook AL, Wyhs N, Sur S, Ptak B, Popoli M, Dobbyn L, Papadopoulos T, Bettegowda C, Papadopoulos N, Vogelstein B, Zhou S, Kinzler KW. 2022. TSGKO_RNASeq. European Genome-Phenome Archive. https:\/\/ega-archive.org\/datasets\/EGAD00001008559. EGAD00001008559."}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/95952\/elife-95952-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/95952\/elife-95952-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/95952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:55:42Z","timestamp":1787565342000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/95952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":93,"alternative-id":["10.7554\/eLife.95952"],"URL":"https:\/\/doi.org\/10.7554\/elife.95952","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.12.28.573594","asserted-by":"subject"}],"references":[{"id-type":"accession","id":"EGAD00001008559","asserted-by":"subject"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.95952.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.95952.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.95952.2","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"doi","id":"10.17632\/pyzxxvjphk.4","asserted-by":"subject"},{"id-type":"doi","id":"10.5061\/dryad.69p8cz9dj","asserted-by":"subject"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,17]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP95952"}}