{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:19:58Z","timestamp":1787570398593,"version":"build-2736575974"},"reference-count":89,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["10.35802\/105570"],"award-info":[{"award-number":["10.35802\/105570"],"id":[{"id":"10.35802\/105570","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["10.35802\/101766"],"award-info":[{"award-number":["10.35802\/101766"],"id":[{"id":"10.35802\/101766","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["10.35802\/207511"],"award-info":[{"award-number":["10.35802\/207511"],"id":[{"id":"10.35802\/207511","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009187","name":"Medical Research Foundation","doi-asserted-by":"publisher","award":["MR_N007727_1"],"award-info":[{"award-number":["MR_N007727_1"]}],"id":[{"id":"10.13039\/501100009187","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SGL021\\1045"],"award-info":[{"award-number":["SGL021\\1045"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001320","name":"Wolfson Foundation","doi-asserted-by":"publisher","award":["WLR\\R1\\170024"],"award-info":[{"award-number":["WLR\\R1\\170024"]}],"id":[{"id":"10.13039\/501100001320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,5,28]]},"abstract":"<jats:p>\n                    Tuberculosis is a major global health problem and is one of the top 10 causes of death worldwide. There is a pressing need for new treatments that circumvent emerging antibiotic resistance.\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    parasitises macrophages, reprogramming them to establish a niche in which to proliferate, therefore macrophage manipulation is a potential host-directed therapy if druggable molecular targets could be identified. The pseudokinase Tribbles1 (Trib1) regulates multiple innate immune processes and inflammatory profiles making it a potential drug target in infections. Trib1 controls macrophage function, cytokine production, and macrophage polarisation. Despite wide-ranging effects on leukocyte biology, data exploring the roles of Tribbles in infection in vivo are limited. Here, we identify that human Tribbles1 is expressed in monocytes and is upregulated at the transcript level after stimulation with mycobacterial antigen. To investigate the mechanistic roles of Tribbles in the host response to mycobacteria in vivo, we used a zebrafish\n                    <jats:italic>Mycobacterium marinum<\/jats:italic>\n                    (Mm) infection tuberculosis model. Zebrafish Tribbles family members were characterised and shown to have substantial mRNA and protein sequence homology to their human orthologues.\n                    <jats:italic>trib1<\/jats:italic>\n                    overexpression was host-protective against Mm infection, reducing burden by approximately 50%. Conversely,\n                    <jats:italic>trib1<\/jats:italic>\n                    knockdown\/knockout exhibited increased infection. Mechanistically,\n                    <jats:italic>trib1<\/jats:italic>\n                    overexpression significantly increased the levels of proinflammatory factors\n                    <jats:italic>il-1\u03b2<\/jats:italic>\n                    and nitric oxide. The host-protective effect of\n                    <jats:italic>trib1<\/jats:italic>\n                    was found to be dependent on the E3 ubiquitin kinase Cop1. These findings highlight the importance of Trib1 and Cop1 as immune regulators during infection in vivo and suggest that enhancing macrophage TRIB1 levels may provide a tractable therapeutic intervention to improve bacterial infection outcomes in tuberculosis.\n                  <\/jats:p>","DOI":"10.7554\/elife.95980","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T05:15:23Z","timestamp":1716959723000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.95980","source":"Crossref","is-referenced-by-count":2,"title":["Tribbles1 is host protective during in vivo mycobacterial infection"],"prefix":"10.7554","volume":"13","author":[{"given":"Ffion R","family":"Hammond","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05krs5044","id-type":"ROR","asserted-by":"publisher"}],"name":"The Bateson Centre, School of Medicine and Population Health, Faculty of Health, University of Sheffield","place":["Sheffield, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1156-3592","authenticated-orcid":true,"given":"Amy","family":"Lewis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05krs5044","id-type":"ROR","asserted-by":"publisher"}],"name":"The Bateson Centre, School of Medicine and Population Health, Faculty of Health, University of Sheffield","place":["Sheffield, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Gabriele","family":"Pollara","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infection & Immunity, University College London","place":["London, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4342-3161","authenticated-orcid":true,"given":"Gillian S","family":"Tomlinson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infection & Immunity, University College London","place":["London, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4774-0853","authenticated-orcid":true,"given":"Mahdad","family":"Noursadeghi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infection & Immunity, University College London","place":["London, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4406-4017","authenticated-orcid":true,"given":"Endre","family":"Kiss-Toth","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05krs5044","id-type":"ROR","asserted-by":"publisher"}],"name":"The Bateson Centre, School of Medicine and Population Health, Faculty of Health, University of Sheffield","place":["Sheffield, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1683-0749","authenticated-orcid":true,"given":"Philip M","family":"Elks","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05krs5044","id-type":"ROR","asserted-by":"publisher"}],"name":"The Bateson Centre, School of Medicine and Population Health, Faculty of Health, University of Sheffield","place":["Sheffield, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.747799","type":"journal-article","article-title":"Macrophage: a cell with many faces and functions in tuberculosis","volume":"13","author":"Ahmad","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020735","type":"journal-article","article-title":"Mycobacteriophages as potential therapeutic agents against drug-resistant tuberculosis","volume":"22","author":"Allu\u00e9-Guardia","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1097\/MOL.0b013e3283508c3b","type":"journal-article","article-title":"The tribbles gene family and lipoprotein metabolism","volume":"23","author":"Angyal","year":"2012","journal-title":"Current Opinion in Lipidology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"11527","DOI":"10.1074\/jbc.RA117.000703","type":"journal-article","article-title":"Tribbles homolog 1 deficiency modulates function and polarization of murine bone marrow-derived macrophages","volume":"293","author":"Arndt","year":"2018","journal-title":"The Journal of Biological Chemistry"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02305-6","type":"journal-article","article-title":"Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis","volume":"8","author":"Athanasiadis","year":"2017","journal-title":"Nature Communications"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"3944","DOI":"10.1182\/blood-2010-03-267419","type":"journal-article","article-title":"Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants","volume":"116","author":"Balla","year":"2010","journal-title":"Blood"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005469","type":"journal-article","article-title":"In vivo molecular dissection of the effects of HIV-1 in Active Tuberculosis","volume":"12","author":"Bell","year":"2016","journal-title":"PLOS Pathogens"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.3791\/3781","type":"journal-article","article-title":"Infection of zebrafish embryos with intracellular bacterial pathogens","volume":"01","author":"Benard","year":"2012","journal-title":"Journal of Visualized Experiments"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1016\/j.celrep.2019.01.071","type":"journal-article","article-title":"CFTR protects against mycobacterium abscessus infection by fine-tuning host oxidative defenses","volume":"26","author":"Bernut","year":"2019","journal-title":"Cell Reports"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1038\/srep21489","type":"journal-article","article-title":"Cryptococcus neoformans intracellular proliferation and capsule size determines early macrophage control of infection","volume":"6","author":"Bojarczuk","year":"2016","journal-title":"Scientific Reports"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215592","type":"journal-article","article-title":"A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase","volume":"14","author":"Buchan","year":"2019","journal-title":"PLOS ONE"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1161\/CIRCRESAHA.116.309463","type":"journal-article","article-title":"Phosphorylation of CHOP (C\/EBP Homologous Protein) by the AMP-activated protein Kinase Alpha 1 in macrophages promotes chop degradation and reduces injury-induced neointimal disruption in vivo","volume":"119","author":"Dai","year":"2016","journal-title":"Circulation Research"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201906719","type":"journal-article","article-title":"Zebrafish embryos allow prediction of nanoparticle circulation times in mice and facilitate quantification of nanoparticle-cell interactions","volume":"16","author":"Dal","year":"2020","journal-title":"Small"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002093","type":"journal-article","article-title":"Mycobacterium tuberculosis uses host triacylglycerol to accumulate lipid droplets and acquires a dormancy-like phenotype in lipid-loaded macrophages","volume":"7","author":"Daniel","year":"2011","journal-title":"PLOS Pathogens"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109530","type":"journal-article","article-title":"Drosophila tribbles antagonizes insulin signaling-mediated growth and metabolism via interactions with Akt kinase","volume":"9","author":"Das","year":"2014","journal-title":"PLOS ONE"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/s1074-7613(02)00475-2","type":"journal-article","article-title":"Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos","volume":"17","author":"Davis","year":"2002","journal-title":"Immunity"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.str.2016.12.008","type":"journal-article","article-title":"STK40 Is a Pseudokinase that binds the E3 ubiquitin ligase COP1","volume":"25","author":"Durzynska","year":"2017","journal-title":"Structure"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/978-1-61779-207-6_18","type":"journal-article","article-title":"Measuring inflammatory cell migration in the zebrafish","volume":"769","author":"Elks","year":"2011","journal-title":"Methods in Molecular Biology"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003789","type":"journal-article","article-title":"Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism","volume":"9","author":"Elks","year":"2013","journal-title":"PLOS Pathogens"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100928","type":"journal-article","article-title":"Mycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection model","volume":"9","author":"Elks","year":"2014","journal-title":"PLOS ONE"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1016\/j.molimm.2008.02.025","type":"journal-article","article-title":"Differential contribution of neutrophilic granulocytes and macrophages to nitrosative stress in a host-parasite animal model","volume":"45","author":"Forlenza","year":"2008","journal-title":"Mol Immunol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/s0092-8674(00)80862-4","type":"journal-article","article-title":"A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila","volume":"101","author":"Grosshans","year":"2000","journal-title":"Cell"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.celrep.2019.12.015","type":"journal-article","article-title":"Mycobacterium tuberculosis limits host glycolysis and IL-1\u03b2 by restriction of PFK-M via MicroRNA-21","volume":"30","author":"Hackett","year":"2020","journal-title":"Cell Reports"},{"key":"bib24","first-page":"2661","type":"journal-article","article-title":"Molecular detection of mutations in isolates of multidrug resistant tuberculosis and tuberculosis suspects by multiplex allele specific PCR","volume":"31","author":"Hameed","year":"2018","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049966","type":"journal-article","article-title":"An arginase 2 promoter transgenic line illuminates immune cell polarisation in zebrafish","volume":"16","author":"Hammond","year":"2023","journal-title":"Disease Models & Mechanisms"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1007\/s00018-006-6007-9","type":"journal-article","article-title":"Tribbles: novel regulators of cell function; evolutionary aspects","volume":"63","author":"Hegedus","year":"2006","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.cellsig.2006.06.010","type":"journal-article","article-title":"Tribbles: a family of kinase-like proteins with potent signalling regulatory function","volume":"19","author":"Hegedus","year":"2007","journal-title":"Cellular Signalling"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-210","type":"journal-article","article-title":"Mycobacterium bovis BCG promotes tumor cell survival from tumor necrosis factor-\u03b1-induced apoptosis","volume":"13","author":"Holla","year":"2014","journal-title":"Molecular Cancer"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"587","DOI":"10.7150\/ijbs.29737","type":"journal-article","article-title":"TRIB3 promotes the proliferation and invasion of renal cell carcinoma cells via activating MAPK signaling pathway","volume":"15","author":"Hong","year":"2019","journal-title":"International Journal of Biological Sciences"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.1242\/dev.099085","type":"journal-article","article-title":"Efficient CRISPR\/Cas9 genome editing with low off-target effects in zebrafish","volume":"140","author":"Hruscha","year":"2013","journal-title":"Developmen"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01784","type":"journal-article","article-title":"The CXCL12\/CXCR4 signaling axis retains neutrophils at inflammatory sites in Zebrafish","volume":"10","author":"Isles","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aau0597","type":"journal-article","article-title":"Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1","volume":"11","author":"Jamieson","year":"2018","journal-title":"Science Signaling"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1042\/BST20150095","type":"journal-article","article-title":"Tribbles in inflammation","volume":"43","author":"Johnston","year":"2015","journal-title":"Biochemical Society Transactions"},{"key":"bib34","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax9183","type":"journal-article","article-title":"Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion","volume":"5","author":"Johnston","year":"2019","journal-title":"Science Advances"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","type":"journal-article","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.cell.2017.12.031","type":"journal-article","article-title":"BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis","volume":"172","author":"Kaufmann","year":"2018","journal-title":"Cell"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/imr.12951","type":"journal-article","article-title":"Host-directed therapy to combat mycobacterial infections","volume":"301","author":"Kilin\u00e7","year":"2021","journal-title":"Immunological Reviews"},{"key":"bib38","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-016-0320-z","type":"journal-article","article-title":"Coordinated inhibition of C\/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development","volume":"14","author":"Kim","year":"2016","journal-title":"BMC Biology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"42703","DOI":"10.1074\/jbc.M407732200","type":"journal-article","article-title":"Human tribbles, a protein family controlling mitogen-activated protein kinase cascades","volume":"279","author":"Kiss-Toth","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"key":"bib40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006874","type":"journal-article","article-title":"Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-\u03b3\/HIF-1\u03b1 signaling and supports host defense","volume":"14","author":"Knight","year":"2018","journal-title":"PLOS Pathogens"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899708","type":"journal-article","article-title":"The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export","volume":"38","author":"Kung","year":"2019","journal-title":"The EMBO Journal"},{"key":"bib42","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9451","type":"journal-article","article-title":"HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling","volume":"6","author":"Lai","year":"2015","journal-title":"Nature Communications"},{"key":"bib43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02321","type":"journal-article","article-title":"Hypoxia induces macrophage tnfa expression via cyclooxygenase and prostaglandin E2 in vivo","volume":"10","author":"Lewis","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"bib44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45029-0","type":"journal-article","article-title":"Cebp1 and Cebp\u03b2 transcriptional axis controls eosinophilopoiesis in zebrafish","volume":"15","author":"Li","year":"2024","journal-title":"Nature Communications"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.vetimm.2013.06.001","type":"journal-article","article-title":"Macrophage migration is controlled by Tribbles 1 through the interaction between C\/EBP\u03b2 and TNF-\u03b1","volume":"155","author":"Liu","year":"2013","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1182\/blood.v97.9.2611","type":"journal-article","article-title":"A novel myeloid-restricted zebrafish CCAAT\/enhancer-binding protein with A potent transcriptional activation domain","volume":"97","author":"Lyons","year":"2001","journal-title":"Blood"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1182\/blood.2018872218","type":"journal-article","article-title":"Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program","volume":"133","author":"Mack","year":"2019","journal-title":"Blood"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/s0092-8674(00)80861-2","type":"journal-article","article-title":"Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string\/CDC25 proteolysis","volume":"101","author":"Mata","year":"2000","journal-title":"Cell"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1021\/acsinfecdis.8b00301","type":"journal-article","article-title":"Quantitative lipid droplet proteomics reveals mycobacterium tuberculosis induced alterations in macrophage response to infection","volume":"5","author":"Menon","year":"2019","journal-title":"ACS Infectious Diseases"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1183\/09031936.00061113","type":"journal-article","article-title":"A case of resistance beyond extensively drug-resistant tuberculosis in Japan","volume":"42","author":"Migliori","year":"2013","journal-title":"The European Respiratory Journal"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1016\/j.str.2015.08.017","type":"journal-article","article-title":"Molecular mechanism of CCAAT-Enhancer binding protein recruitment by the TRIB1 Pseudokinase","volume":"23","author":"Murphy","year":"2015","journal-title":"Structure"},{"key":"bib52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.574046","type":"journal-article","article-title":"Tribbles-1 expression and its function to control inflammatory cytokines, including interleukin-8 levels are regulated by miRNAs in macrophages and prostate cancer cells","volume":"11","author":"Niespolo","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/gtc.12913","type":"journal-article","article-title":"Sima, a Drosophila homolog of HIF-1\u03b1, in fat body tissue inhibits larval body growth by inducing Tribbles gene expression","volume":"27","author":"Noguchi","year":"2022","journal-title":"Genes Cells"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"494","DOI":"10.4049\/jimmunol.1801139","type":"journal-article","article-title":"Hif-1\u03b1-induced expression of Il-1\u03b2 protects against mycobacterial infection in Zebrafish","volume":"202","author":"Ogryzko","year":"2019","journal-title":"Journal of Immunology"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.bbagrm.2018.01.014","type":"journal-article","article-title":"TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C\/EBP\u2013ATF response elements in the FGF21 promoter","volume":"1861","author":"\u00d6rd","year":"2018","journal-title":"Biochimica et Biophysica Acta"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008981","type":"journal-article","article-title":"A human-specific VNTR in the TRIB3 promoter causes gene expression variation between individuals","volume":"16","author":"\u00d6rd","year":"2020","journal-title":"PLOS Genetics"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.2337\/db09-1537","type":"journal-article","article-title":"Control of adipose tissue inflammation through TRB1","volume":"59","author":"Ostertag","year":"2010","journal-title":"Diabetes"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/pro.3943","type":"journal-article","article-title":"UCSF ChimeraX: Structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Science"},{"key":"bib59","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abg7673","type":"journal-article","article-title":"Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease","volume":"13","author":"Pollara","year":"2021","journal-title":"Science Translational Medicine"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1210\/er.2011-1042","type":"journal-article","article-title":"The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases","volume":"33","author":"Prudente","year":"2012","journal-title":"Endocrine Reviews"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1126\/science.1123374","type":"journal-article","article-title":"TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism","volume":"312","author":"Qi","year":"2006","journal-title":"Science"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"3976","DOI":"10.1182\/blood-2006-05-024075","type":"journal-article","article-title":"A transgenic zebrafish model of neutrophilic inflammation","volume":"108","author":"Renshaw","year":"2006","journal-title":"Blood"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"4017","DOI":"10.1158\/0008-5472.CAN-11-3148","type":"journal-article","article-title":"A zebrafish model to study and therapeutically manipulate hypoxia signaling in tumorigenesis","volume":"72","author":"Santhakumar","year":"2012","journal-title":"Cancer Research"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nature11930","type":"journal-article","article-title":"Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages","volume":"495","author":"Satoh","year":"2013","journal-title":"Nature"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1111\/febs.15433","type":"journal-article","article-title":"Hif-1alpha stabilisation is protective against infection in zebrafish comorbid models","volume":"287","author":"Schild","year":"2020","journal-title":"The FEBS Journal"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","type":"journal-article","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nature Methods"},{"key":"bib67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031270","type":"journal-article","article-title":"Kinome-wide functional genomics screen reveals a novel mechanism of TNF\u03b1-induced nuclear accumulation of the HIF-1\u03b1 transcription factor in cancer cells","volume":"7","author":"Schoolmeesters","year":"2012","journal-title":"PLOS ONE"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/S0960-9822(00)00502-9","type":"journal-article","article-title":"Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation","volume":"10","author":"Seher","year":"2000","journal-title":"Current Biology"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/imm.13276","type":"journal-article","article-title":"Targeting immunometabolism in host defence against Mycobacterium tuberculosis","volume":"162","author":"Sheedy","year":"2021","journal-title":"Immunology"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1089\/met.2015.0037","type":"journal-article","article-title":"Tribbles homolog 3 promotes foam cell formation associated with decreased proinflammatory cytokine production in macrophages: Evidence for reciprocal regulation of cholesterol uptake and inflammation","volume":"14","author":"Steverson","year":"2016","journal-title":"Metabolic Syndrome and Related Disorders"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1242\/dmm.006676","type":"journal-article","article-title":"Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component","volume":"4","author":"Stoop","year":"2011","journal-title":"Disease Models & Mechanisms"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1194\/jlr.M700545-JLR200","type":"journal-article","article-title":"TRB3 suppresses adipocyte differentiation by negatively regulating PPARgamma transcriptional activity","volume":"49","author":"Takahashi","year":"2008","journal-title":"Journal of Lipid Research"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nprot.2007.514","type":"journal-article","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nature Protocols"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1016\/j.molimm.2009.03.024","type":"journal-article","article-title":"Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components","volume":"46","author":"van der Sar","year":"2009","journal-title":"Molecular Immunology"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","type":"journal-article","article-title":"AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Research"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"463","DOI":"10.2337\/db11-0518","type":"journal-article","article-title":"Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE-\/-\/LDL receptor-\/- mice","volume":"61","author":"Wang","year":"2012","journal-title":"Diabetes"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.2147\/DMSO.S278684","type":"journal-article","article-title":"Adiponectin protects obese rats from aggravated acute lung injury via suppression of endoplasmic reticulum stress","volume":"13","author":"Wei","year":"2020","journal-title":"Diabetes, Metabolic Syndrome and Obesity"},{"key":"bib78","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2934","type":"journal-article","article-title":"Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response","volume":"13","author":"Wennemers","year":"2011","journal-title":"Breast Cancer Research"},{"key":"bib79","type":"web-resource","article-title":"Global tuberculosis report 2022","author":"WHO","year":"2022","unstructured":"WHO. 2022. Global tuberculosis report 2022. https:\/\/www.who.int\/publications\/i\/item\/9789240061729 [Accessed October 27, 2022]."},{"key":"bib80","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/895179","type":"journal-article","article-title":"Systematic expression profiling analysis identifies specific microRNA-gene interactions that may differentiate between active and latent tuberculosis infection","volume":"2014","author":"Wu","year":"2014","journal-title":"BioMed Research International"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"13195","DOI":"10.2147\/CMAR.S287956","type":"journal-article","article-title":"TRIB3 promotes lung adenocarcinoma progression via an enhanced warburg effect","volume":"12","author":"Xing","year":"2020","journal-title":"Cancer Management and Research"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1182\/blood-2009-10-246264","type":"journal-article","article-title":"Trib1 links the MEK1\/ERK pathway in myeloid leukemogenesis","volume":"116","author":"Yokoyama","year":"2010","journal-title":"Blood"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1182\/blood-2012-12-476101","type":"journal-article","article-title":"COP1 targets C\/EBP\u03b1 for degradation and induces acute myeloid leukemia via Trib1","volume":"122","author":"Yoshida","year":"2013","journal-title":"Blood"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"7014","DOI":"10.1182\/blood-2010-12-325712","type":"journal-article","article-title":"Sumoylation of CCAAT\/enhancer-binding protein \u03b1 promotes the biased primitive hematopoiesis of zebrafish","volume":"117","author":"Yuan","year":"2011","journal-title":"Blood"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1002\/prot.26292","type":"journal-article","article-title":"Molecular dynamics and structural analysis of the binding of COP1 E3 ubiquitin ligase to \u03b2-catenin and TRIB pseudokinases","volume":"90","author":"Zahid","year":"2022","journal-title":"Proteins"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"4192","DOI":"10.2337\/db13-0312","type":"journal-article","article-title":"TRIB3 mediates glucose-induced insulin resistance via a mechanism that requires the hexosamine biosynthetic pathway","volume":"62","author":"Zhang","year":"2013","journal-title":"Diabetes"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3109\/08830185.2014.969421","type":"journal-article","article-title":"Cellular metabolism and macrophage functional polarization","volume":"34","author":"Zhu","year":"2015","journal-title":"International Reviews of Immunology"},{"key":"dataset1","type":"dataset","article-title":"Monocytes from people with active or latent TB stimulated in vitro with PPD","volume-title":"EBI ArrayExpress","author":"Pollara","year":"2021","unstructured":"Pollara G. 2021. Monocytes from people with active or latent TB stimulated in vitro with PPD. EBI ArrayExpress. https:\/\/www.ebi.ac.uk\/biostudies\/arrayexpress\/studies\/E-MTAB-8162. E-MTAB-8162."},{"key":"dataset2","type":"dataset","article-title":"Transcriptional profiling of the tuberculin skin test in patients with active and latent tuberculosis","volume-title":"EBI ArrayExpress","author":"Pollara","year":"2019","unstructured":"Pollara G. 2019. Transcriptional profiling of the tuberculin skin test in patients with active and latent tuberculosis. EBI ArrayExpress. https:\/\/www.ebi.ac.uk\/biostudies\/arrayexpress\/studies\/E-MTAB-6816. E-MTAB-6816."}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/95980\/elife-95980-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/95980\/elife-95980-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/95980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:27:14Z","timestamp":1787567234000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/95980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":89,"alternative-id":["10.7554\/eLife.95980"],"URL":"https:\/\/doi.org\/10.7554\/elife.95980","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.08.25.553505","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2023.08.25.553505","asserted-by":"object"}],"references":[{"id-type":"accession","id":"E-MTAB-8162","asserted-by":"subject"},{"id-type":"accession","id":"E-MTAB-6816","asserted-by":"subject"}],"is-financed-by":[{"id-type":"doi","id":"10.35802\/105570","asserted-by":"subject"},{"id-type":"doi","id":"10.35802\/101766","asserted-by":"subject"},{"id-type":"doi","id":"10.35802\/207511","asserted-by":"subject"},{"id-type":"doi","id":"10.35802\/105570","asserted-by":"object"},{"id-type":"doi","id":"10.35802\/207511","asserted-by":"object"},{"id-type":"doi","id":"10.35802\/101766","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.95980.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.95980.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.95980.sa0","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e95980"}}