{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:14:46Z","timestamp":1785420886949,"version":"3.56.0"},"reference-count":10,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    A build-up of eggs in the uterus of the nematode\n                    <jats:italic>C. elegans<\/jats:italic>\n                    triggers the release of large extracellular vesicles, called exophers, from neurons that are sensitive to mechanical forces.\n                  <\/jats:p>","DOI":"10.7554\/elife.96813","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T09:15:06Z","timestamp":1710148506000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.96813","source":"Crossref","is-referenced-by-count":1,"title":["Mechanosensory neurons under pressure"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8129-1326","authenticated-orcid":true,"given":"Erin","family":"Cram","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04t5xt781","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biology, Northeastern University","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.tcb.2015.01.004","article-title":"Ectosomes and exosomes: shedding the confusion between extracellular vesicles","volume":"25","author":"Cocucci","year":"2015","journal-title":"Trends in Cell Biology"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2101410118","article-title":"Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS\/MAPK signaling","volume":"118","author":"Cooper","year":"2021","journal-title":"PNAS"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1016\/j.neuron.2022.07.001","article-title":"PIEZO channels and newcomers in the mammalian mechanosensitive ion channel family","volume":"110","author":"Delmas","year":"2022","journal-title":"Neuron"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nature21362","article-title":"C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress","volume":"542","author":"Melentijevic","year":"2017","journal-title":"Nature"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1146\/annurev-cellbio-120319-030049","article-title":"Components and mechanisms of nuclear mechanotransduction","volume":"37","author":"Niethammer","year":"2021","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"150","DOI":"10.14336\/AD.2015.0820","article-title":"The role of autophagy, mitophagy and lysosomal functions in modulating bioenergetics and survival in the context of redox and proteotoxic damage: implications for neurodegenerative diseases","volume":"7","author":"Redmann","year":"2016","journal-title":"Aging and Disease"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202052071","article-title":"Muscle-derived exophers promote reproductive fitness","volume":"22","author":"Turek","year":"2021","journal-title":"EMBO Reports"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.82227","article-title":"Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell","volume":"12","author":"Wang","year":"2023","journal-title":"eLife"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.95443","article-title":"Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons","volume":"13","author":"Wang","year":"2024","journal-title":"eLife"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s43587-023-00548-1","article-title":"Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons","volume":"4","author":"Yang","year":"2024","journal-title":"Nature Aging"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/96813\/elife-96813-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/96813\/elife-96813-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/96813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:30:47Z","timestamp":1710325847000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/96813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":10,"alternative-id":["10.7554\/eLife.96813"],"URL":"https:\/\/doi.org\/10.7554\/elife.96813","archive":["CLOCKSS"],"relation":{},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]},"article-number":"e96813"}}