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Here, we characterized the ion transport peptide (ITP) signaling system in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    . The\n                    <jats:italic>Drosophila ITP<\/jats:italic>\n                    gene can generate three different peptide isoforms: ITP amidated (ITPa) and two ITP-like (ITPL1 and ITPL2) isoforms. We comprehensively characterized the expression of all three ITP isoforms in the nervous system and peripheral tissues. Our analyses reveal widespread expression of ITP isoforms. Moreover, we show that ITPa-producing neurons are activated and release ITPa during dehydration. Furthermore, recombinant\n                    <jats:italic>Drosophila<\/jats:italic>\n                    ITPa inhibits diuretic peptide-induced renal tubule secretion ex vivo, thus confirming its role as an anti-diuretic hormone. Using a phylogenetic-driven approach, an ex vivo secretion assay and a heterologous mammalian cell-based assay, we identified and functionally characterized Gyc76C, a membrane guanylate cyclase, as a bona fide\n                    <jats:italic>Drosophila<\/jats:italic>\n                    ITPa receptor. Extensive anatomical mapping of Gyc76C reveals that it is highly expressed in larval and adult tissues associated with osmoregulation (renal tubules and rectum) and metabolic homeostasis (fat body). Consistent with this expression, knockdown of Gyc76C in renal tubules impacts tolerance to osmotic and ionic stresses, whereas knockdown specifically in the fat body impacts feeding, nutrient homeostasis, and associated behaviors. We also complement receptor knockdown experiments with\n                    <jats:italic>ITP<\/jats:italic>\n                    knockdown and ITPa overexpression in ITPa-producing neurons. Lastly, we utilized connectomics and single-cell transcriptomics to identify pathways via which ITP neurons integrate hygrosensory inputs and interact with other homeostatic hormonal pathways. Taken together, our systematic characterization of ITP signaling establishes a tractable system to decipher how a small set of neurons integrates diverse inputs to orchestrate systemic homeostasis in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.7554\/elife.97043","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T13:29:07Z","timestamp":1715088547000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.97043","source":"Crossref","is-referenced-by-count":5,"title":["Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-1546","authenticated-orcid":true,"given":"Jayati","family":"Gera","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology and 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