{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:35:54Z","timestamp":1787567754836,"version":"build-2736575974"},"reference-count":26,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Interdisciplinary Center for Clinical Research within the faculty of Medicine at the RWTH Aachen University"},{"name":"NWO-ZonMw Veni","award":["91619053"],"award-info":[{"award-number":["91619053"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["DFG SFB\/TRR219, Project ID 322900939, Subproject M07"],"award-info":[{"award-number":["DFG SFB\/TRR219, Project ID 322900939, Subproject M07"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016021","name":"Corona-Stiftung","doi-asserted-by":"publisher","award":["S199\/10084\/2021"],"award-info":[{"award-number":["S199\/10084\/2021"]}],"id":[{"id":"10.13039\/100016021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003390","name":"Fritz Thyssen Stiftung","doi-asserted-by":"publisher","award":["10.20.2.043MN"],"award-info":[{"award-number":["10.20.2.043MN"]}],"id":[{"id":"10.13039\/501100003390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["ZK81-B"],"award-info":[{"award-number":["ZK81-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/P36774"],"award-info":[{"award-number":["10.55776\/P36774"],"id":[{"id":"10.55776\/p36774","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["BA6226\/2-1"],"award-info":[{"award-number":["BA6226\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["BA6226\/2-3"],"award-info":[{"award-number":["BA6226\/2-3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008672","name":"Wilhelm Sander Foundation","doi-asserted-by":"publisher","award":["2018.129.1"],"award-info":[{"award-number":["2018.129.1"]}],"id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]},{"name":"COST Action Mye-InfoBank 476","award":["CA20117"],"award-info":[{"award-number":["CA20117"]}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["16LW0143 Mamma-Explant"],"award-info":[{"award-number":["16LW0143 Mamma-Explant"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State of NRW","award":["ZM-1-27B NovoKolon"],"award-info":[{"award-number":["ZM-1-27B NovoKolon"]}]},{"DOI":"10.13039\/501100007210","name":"RWTH Aachen University","doi-asserted-by":"publisher","award":["ERS grant G:(DE-82)EXS-SF-OPSF732"],"award-info":[{"award-number":["ERS grant G:(DE-82)EXS-SF-OPSF732"]}],"id":[{"id":"10.13039\/501100007210","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["Project ID 310030-197655"],"award-info":[{"award-number":["Project ID 310030-197655"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["CSC stipend 202008320329"],"award-info":[{"award-number":["CSC stipend 202008320329"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["SFB TRR219, Project ID 322900939"],"award-info":[{"award-number":["SFB TRR219, Project ID 322900939"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["CRC 1382, Project-ID: 403224013"],"award-info":[{"award-number":["CRC 1382, Project-ID: 403224013"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["Cluster4Future: Cluster for Nucleic Acid Therapeutics Munich (CNATM)"],"award-info":[{"award-number":["Cluster4Future: Cluster for Nucleic Acid Therapeutics Munich (CNATM)"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["Meer Kennis met Minder Dieren 114022505"],"award-info":[{"award-number":["Meer Kennis met Minder Dieren 114022505"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    The prevalence of metabolic dysfunction-associated steatohepatitis (MASH) is increasing, urging more research into the underlying mechanisms. MicroRNA-26b (\n                    <jats:italic>Mir26b<\/jats:italic>\n                    ) might play a role in several MASH-related pathways. Therefore, we aimed to determine the role of\n                    <jats:italic>Mir26b<\/jats:italic>\n                    in MASH and its therapeutic potential using\n                    <jats:italic>Mir26b<\/jats:italic>\n                    mimic-loaded lipid nanoparticles (LNPs).\n                    <jats:italic>\n                      Apoe\n                      <jats:sup>-\/-<\/jats:sup>\n                      Mir26b\n                      <jats:sup>-\/-<\/jats:sup>\n                    <\/jats:italic>\n                    ,\n                    <jats:italic>\n                      Apoe\n                      <jats:sup>-\/-<\/jats:sup>\n                      Lyz2\n                      <jats:sup>cre<\/jats:sup>\n                      Mir26b\n                      <jats:sup>fl\/fl<\/jats:sup>\n                    <\/jats:italic>\n                    mice, and respective controls were fed a Western-type diet to induce MASH. Plasma and liver samples were characterized regarding lipid metabolism, hepatic inflammation, and fibrosis. Additionally,\n                    <jats:italic>Mir26b<\/jats:italic>\n                    mimic-loaded LNPs were injected in\n                    <jats:italic>\n                      Apoe\n                      <jats:sup>-\/-<\/jats:sup>\n                      Mir26b\n                      <jats:sup>-\/-<\/jats:sup>\n                    <\/jats:italic>\n                    mice to rescue the phenotype and key results were validated in human precision-cut liver slices. Finally, kinase profiling was used to elucidate underlying mechanisms.\n                    <jats:italic>\n                      Apoe\n                      <jats:sup>-\/-<\/jats:sup>\n                      Mir26b\n                      <jats:sup>-\/-<\/jats:sup>\n                    <\/jats:italic>\n                    mice showed increased hepatic lipid levels, coinciding with increased expression of scavenger receptor a and platelet glycoprotein 4. Similar effects were found in mice lacking myeloid-specific\n                    <jats:italic>Mir26b<\/jats:italic>\n                    . Additionally, hepatic TNF and IL-6 levels and amount of infiltrated macrophages were increased in\n                    <jats:italic>\n                      Apoe\n                      <jats:sup>-\/-<\/jats:sup>\n                      Mir26b\n                      <jats:sup>-\/-<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Moreover,\n                    <jats:italic>Tgfb<\/jats:italic>\n                    expression was increased by the\n                    <jats:italic>Mir26b<\/jats:italic>\n                    deficiency, leading to more hepatic fibrosis. A murine treatment model with\n                    <jats:italic>Mir26b<\/jats:italic>\n                    mimic-loaded LNPs reduced hepatic lipids, rescuing the observed phenotype. Kinase profiling identified increased inflammatory signaling upon\n                    <jats:italic>Mir26b<\/jats:italic>\n                    deficiency, which was rescued by LNP treatment. Finally,\n                    <jats:italic>Mir26b<\/jats:italic>\n                    mimic-loaded LNPs also reduced inflammation in human precision-cut liver slices. Overall, our study demonstrates that the detrimental effects of\n                    <jats:italic>Mir26b<\/jats:italic>\n                    deficiency in MASH can be rescued by LNP treatment. This novel discovery leads to more insight into MASH development, opening doors to potential new treatment options using LNP technology.\n                  <\/jats:p>","DOI":"10.7554\/elife.97165","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T08:25:12Z","timestamp":1722846312000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.97165","source":"Crossref","is-referenced-by-count":0,"title":["MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles"],"prefix":"10.7554","volume":"13","author":[{"given":"Linsey","family":"Peters","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/02jz4aj89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University","place":["Maastricht, Netherlands"]},{"id":[{"id":"https:\/\/ror.org\/05591te55","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","place":["Munich, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Leonida","family":"Rakateli","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University","place":["Aachen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Rosanna","family":"Huchzermeier","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University","place":["Aachen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Andrea","family":"Bonnin-Marquez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University","place":["Aachen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Sanne L","family":"Maas","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University","place":["Aachen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Cheng","family":"Lin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ypbx660","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Rheumatology and Shanghai Institute of Rheumatology, Renji","place":["Shanghai, China"]},{"id":[{"id":"https:\/\/ror.org\/02gm5zw39","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine III, University Hospital Aachen","place":["Aachen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Alexander","family":"Jans","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ypbx660","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Rheumatology and Shanghai Institute of Rheumatology, Renji","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Yana","family":"Geng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/012p63287","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen","place":["Groningen, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Alan","family":"Gorter","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/012p63287","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen","place":["Groningen, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Marion","family":"Gijbels","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jz4aj89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University","place":["Maastricht, Netherlands"]},{"id":[{"id":"https:\/\/ror.org\/03t4gr691","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences: Atherosclerosis & Ischemic Syndrome; Amsterdam Infection and Immunity: Inflammatory diseases; Amsterdam UMC location University of Amsterdam","place":["Amsterdam, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Sander","family":"Rensen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jz4aj89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University","place":["Maastricht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Peter","family":"Olinga","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/012p63287","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen","place":["Groningen, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Tim","family":"Hendrikx","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Laboratory Medicine, Medical University Vienna","place":["Vienna, Austria"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Marcin","family":"Krawczyk","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mz5ra38","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Gastroenterology, Hepatology and Transplant Medicine, Medical Faculty, University of Duisburg","place":["Essen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Malvina","family":"Brisbois","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01jdpyv68","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine II, Saarland University Medical Center, Saarland University","place":["Homburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Joachim","family":"Jankowski","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/02jz4aj89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University","place":["Maastricht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Kiril","family":"Bidzhekov","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05591te55","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","place":["Munich, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Christian","family":"Weber","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05591te55","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","place":["Munich, Germany"]},{"id":[{"id":"https:\/\/ror.org\/031t5w623","id-type":"ROR","asserted-by":"publisher"}],"name":"DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance","place":["Munich, Germany"]},{"id":[{"id":"https:\/\/ror.org\/02jz4aj89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University","place":["Maastricht, Netherlands"]},{"id":[{"id":"https:\/\/ror.org\/025z3z560","id-type":"ROR","asserted-by":"publisher"}],"name":"Munich Cluster for Systems Neurology (SyNergy)","place":["Munich, Germany"]},{"name":"Cluster for Nucleic Acid Therapeutics Munich (CNATM)","place":["Munich, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Erik AL","family":"Biessen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/02jz4aj89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University","place":["Maastricht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-7814","authenticated-orcid":true,"given":"Ronit","family":"Shiri-Sverdlov","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jz4aj89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics and Cell Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), University of Maastricht","place":["Maastricht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Tom","family":"Houben","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jz4aj89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics and Cell Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), University of Maastricht","place":["Maastricht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Yvonne","family":"D\u00f6ring","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05591te55","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","place":["Munich, Germany"]},{"id":[{"id":"https:\/\/ror.org\/031t5w623","id-type":"ROR","asserted-by":"publisher"}],"name":"DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance","place":["Munich, Germany"]},{"id":[{"id":"https:\/\/ror.org\/01q9sj412","id-type":"ROR","asserted-by":"publisher"}],"name":"Swiss Cardiovascular Center, Division of Angiology, Inselspital, Bern University Hospital, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Matthias","family":"Bartneck","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ypbx660","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Rheumatology and Shanghai Institute of Rheumatology, Renji","place":["Shanghai, China"]},{"id":[{"id":"https:\/\/ror.org\/0186h8060","id-type":"ROR","asserted-by":"publisher"}],"name":"DWI \u2013 Leibniz Institute for Interactive Materials","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Technical and Macromolecular Chemistry, RWTH Aachen University","place":["Aachen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-6278","authenticated-orcid":true,"given":"Emiel","family":"van der Vorst","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University","place":["Aachen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05591te55","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","place":["Munich, Germany"]},{"id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine I - Cardiology, University Hospital, RWTH Aachen University","place":["Aachen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1007\/s10620-016-4049-x","type":"journal-article","article-title":"Innate immunity and inflammation in NAFLD\/NASH","volume":"61","author":"Arrese","year":"2016","journal-title":"Digestive Diseases and Sciences"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1053\/j.gastro.2010.02.051","type":"journal-article","article-title":"Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice","volume":"138","author":"Bieghs","year":"2010","journal-title":"Gastroenterology"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4297206","type":"journal-article","article-title":"Cytokines genotype-phenotype correlation in nonalcoholic steatohepatitis","volume":"2017","author":"Bocsan","year":"2017","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108626","type":"journal-article","article-title":"Dynamic shifts in the composition of resident and recruited macrophages influence tissue remodeling in NASH","volume":"34","author":"Daemen","year":"2021","journal-title":"Cell Reports"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/nprot.2010.111","type":"journal-article","article-title":"Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies","volume":"5","author":"de Graaf","year":"2010","journal-title":"Nature Protocols"},{"key":"bib6","first-page":"614","type":"journal-article","article-title":"TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)","volume":"232","author":"Endo","year":"2007","journal-title":"Experimental Biology and Medicine"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","type":"journal-article","article-title":"MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1136\/gutjnl-2018-318146","type":"journal-article","article-title":"miRNAs and NAFLD: from pathophysiology to therapy","volume":"68","author":"Gjorgjieva","year":"2019","journal-title":"Gut"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.jhep.2021.12.012","type":"journal-article","article-title":"Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease","volume":"76","author":"Govaere","year":"2022","journal-title":"Journal of Hepatology"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114990","type":"journal-article","article-title":"Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications","volume":"200","author":"Jeong","year":"2023","journal-title":"Advanced Drug Delivery Reviews"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.3748\/wjg.v26.i17.1993","type":"journal-article","article-title":"Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease","volume":"26","author":"Katsarou","year":"2020","journal-title":"World Journal of Gastroenterology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.metabol.2006.10.007","type":"journal-article","article-title":"Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells","volume":"56","author":"Kim","year":"2007","journal-title":"Metabolism"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"49982","DOI":"10.1074\/jbc.M209649200","type":"journal-article","article-title":"Scavenger receptors class A-I\/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages","volume":"277","author":"Kunjathoor","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2020.04.012","type":"journal-article","article-title":"Non-alcoholic fatty liver disease and microRNAs expression, how it affects the development and progression of the disease","volume":"21","author":"L\u00f3pez-S\u00e1nchez","year":"2021","journal-title":"Annals of Hepatology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1136\/gutjnl-2021-324243","type":"journal-article","article-title":"Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis","volume":"71","author":"M\u00f3zes","year":"2022","journal-title":"Gut"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4020249","type":"journal-article","article-title":"An overview of lipid metabolism and nonalcoholic fatty liver disease","volume":"2020","author":"Pei","year":"2020","journal-title":"BioMed Research International"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.603926","type":"journal-article","article-title":"Non-alcoholic steatohepatitis: a review of its mechanism","volume":"11","author":"Peng","year":"2020","journal-title":"Models and Medical Treatments. Front Pharmacol"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143185","type":"journal-article","article-title":"Immunomodulatory nanomedicine for the treatment of atherosclerosis","volume":"10","author":"Peters","year":"2021","journal-title":"Journal of Clinical Medicine"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1016\/j.cgh.2018.12.031","type":"journal-article","article-title":"Diagnostic accuracy of noninvasive fibrosis models to detect change in fibrosis stage","volume":"17","author":"Siddiqui","year":"2019","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-023-02220-0","type":"journal-article","article-title":"Transcriptomic profiling of induced steatosis in human and mouse precision-cut liver slices","volume":"10","author":"Simon","year":"2023","journal-title":"Scientific Data"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/hep.21268","type":"journal-article","article-title":"Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis","volume":"44","author":"Uchinami","year":"2006","journal-title":"Hepatology"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-021-00976-1","type":"journal-article","article-title":"Transcriptome signature of miRNA-26b KO mouse model suggests novel targets","volume":"22","author":"van der Vorst","year":"2021","journal-title":"BMC Genomic Data"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.omtn.2019.02.014","type":"journal-article","article-title":"MicroRNA-26b-5p inhibits mouse liver fibrogenesis and angiogenesis by targeting pdgf receptor-beta","volume":"16","author":"Yang","year":"2019","journal-title":"Molecular Therapy. Nucleic Acids"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1093\/bioinformatics\/btu684","type":"journal-article","article-title":"DOSE: an R\/Bioconductor package for disease ontology semantic and enrichment analysis","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1039\/c5mb00663e","type":"journal-article","article-title":"ReactomePA: an R\/Bioconductor package for reactome pathway analysis and visualization","volume":"12","author":"Yu","year":"2016","journal-title":"Molecular bioSystems"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-35","type":"journal-article","article-title":"MicroRNA-26b suppresses the NF-\u03baB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3","volume":"13","author":"Zhao","year":"2014","journal-title":"Molecular Cancer"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/97165\/elife-97165-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/97165\/elife-97165-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/97165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:42:09Z","timestamp":1787564529000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/97165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":26,"alternative-id":["10.7554\/eLife.97165"],"URL":"https:\/\/doi.org\/10.7554\/elife.97165","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.02.18.580792","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2024.02.18.580792","asserted-by":"object"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.97165.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.97165.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.97165.2","asserted-by":"subject"}],"is-financed-by":[{"id-type":"doi","id":"10.55776\/P36774","asserted-by":"subject"},{"id-type":"doi","id":"10.55776\/P36774","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,22]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP97165"}}