{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:31:20Z","timestamp":1792020680818,"version":"4.4.0"},"reference-count":60,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS094184"],"award-info":[{"award-number":["NS094184"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,6,6]]},"abstract":"<jats:p>\n                    A key to motor control is the motor thalamus, where several inputs converge. One excitatory input originates from layer 5 of primary motor cortex (M1\n                    <jats:sub>L5<\/jats:sub>\n                    ), while another arises from the deep cerebellar nuclei (Cb). M1\n                    <jats:sub>L5<\/jats:sub>\n                    terminals distribute throughout the motor thalamus and overlap with GABAergic inputs from the basal ganglia output nuclei, the internal segment of the globus pallidus (GPi), and substantia nigra pars reticulata (SNr). In contrast, it is thought that Cb and basal ganglia inputs are segregated. Therefore, we hypothesized that one potential function of the GABAergic inputs from basal ganglia is to selectively inhibit, or gate, excitatory signals from M1\n                    <jats:sub>L5<\/jats:sub>\n                    in the motor thalamus. Here, we tested this possibility and determined the circuit organization of mouse (both sexes) motor thalamus using an optogenetic strategy in acute slices. First, we demonstrated the presence of a feedforward transthalamic pathway from M1\n                    <jats:sub>L5<\/jats:sub>\n                    through motor thalamus. Importantly, we discovered that GABAergic inputs from the GPi and SNr converge onto single motor thalamic cells with excitatory synapses from M1\n                    <jats:sub>L5<\/jats:sub>\n                    . Separately, we also demonstrate that, perhaps unexpectedly, GABAergic GPi and SNr inputs converge with those from the Cb. We interpret these results to indicate that a role of the basal ganglia is to gate the thalamic transmission of M1\n                    <jats:sub>L5<\/jats:sub>\n                    and Cb information to cortex.\n                  <\/jats:p>","DOI":"10.7554\/elife.97489","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T04:15:07Z","timestamp":1717992907000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.97489","source":"Crossref","is-referenced-by-count":25,"title":["Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2935-3427","authenticated-orcid":true,"given":"Kevin P","family":"Koster","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024mw5h28","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurobiology, University of Chicago","place":["Chicago, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-2778","authenticated-orcid":true,"given":"S Murray","family":"Sherman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024mw5h28","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurobiology, University of Chicago","place":["Chicago, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/0306-4522(91)90333-j","type":"journal-article","article-title":"Thalamocortical responses of mouse somatosensory (barrel) cortex in vitro","volume":"41","author":"Agmon","year":"1991","journal-title":"Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/BF00248792","type":"journal-article","article-title":"An analysis of potentially converging inputs to the rostral ventral thalamic nuclei of the cat","volume":"68","author":"Anderson","year":"1987","journal-title":"Experimental Brain Research"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1016\/j.neuron.2021.04.017","type":"journal-article","article-title":"Visual intracortical and transthalamic pathways carry distinct information to cortical areas","volume":"109","author":"Blot","year":"2021","journal-title":"Neuron"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2013.00163","type":"journal-article","article-title":"Motor thalamus integration of cortical, cerebellar and basal ganglia information: implications for normal and parkinsonian conditions","volume":"7","author":"Bosch-Bouju","year":"2013","journal-title":"Frontiers in Computational Neuroscience"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"8452","DOI":"10.1073\/pnas.1000496107","type":"journal-article","article-title":"The basal ganglia communicate with the cerebellum","volume":"107","author":"Bostan","year":"2010","journal-title":"PNAS"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.neuron.2018.03.024","type":"journal-article","article-title":"Reciprocal circuits linking the prefrontal cortex with dorsal and ventral thalamic nuclei","volume":"98","author":"Collins","year":"2018","journal-title":"Neuron"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/0304-3940(92)90750-2","type":"journal-article","article-title":"Patterns of termination of cerebellar and basal ganglia efferents in the rat thalamus. Strictly segregated and partly overlapping projections","volume":"144","author":"Deniau","year":"1992","journal-title":"Neuroscience Letters"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41586-018-0642-9","type":"journal-article","article-title":"Distinct descending motor cortex pathways and their roles in movement","volume":"563","author":"Economo","year":"2018","journal-title":"Nature"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/cne.20464","type":"journal-article","article-title":"Evidence for \u201cdirect\u201d and \u201cindirect\u201d pathways through the song system basal ganglia","volume":"484","author":"Farries","year":"2005","journal-title":"The Journal of Comparative Neurology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.1111\/ejn.15142","type":"journal-article","article-title":"A change of mind: globus pallidus activity and effective connectivity during changes in choice selections","volume":"53","author":"Fiore","year":"2021","journal-title":"The European Journal of Neuroscience"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"6563","DOI":"10.1523\/JNEUROSCI.0463-18.2018","type":"journal-article","article-title":"Distinct populations of motor thalamic neurons encode action initiation, action selection, and movement vigor","volume":"38","author":"Gaidica","year":"2018","journal-title":"The Journal of Neuroscience"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/nn.3047","type":"journal-article","article-title":"A cortical motor nucleus drives the basal ganglia-recipient thalamus in singing birds","volume":"15","author":"Goldberg","year":"2012","journal-title":"Nature Neuroscience"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.tins.2013.09.001","type":"journal-article","article-title":"Basal ganglia output to the thalamus: still a paradox","volume":"36","author":"Goldberg","year":"2013","journal-title":"Trends in Neurosciences"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1016\/j.celrep.2018.04.098","type":"journal-article","article-title":"Differentiating cerebellar impact on thalamic nuclei","volume":"23","author":"Gornati","year":"2018","journal-title":"Cell Reports"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"8787","DOI":"10.1523\/JNEUROSCI.1333-18.2018","type":"journal-article","article-title":"Anterolateral motor cortex connects with a medial subdivision of ventromedial thalamus through cell type-specific circuits, forming an excitatory thalamo-cortico-thalamic loop via layer 1 apical tuft dendrites of layer 5B pyramidal tract type neurons","volume":"38","author":"Guo","year":"2018","journal-title":"The Journal of Neuroscience"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1523\/JNEUROSCI.2277-19.2020","type":"journal-article","article-title":"Cortico-thalamo-cortical circuits of mouse forelimb S1 are organized primarily as recurrent loops","volume":"40","author":"Guo","year":"2020","journal-title":"The Journal of Neuroscience"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1177\/107385840100700408","type":"journal-article","article-title":"The place of the thalamus in frontal cortical-basal ganglia circuits","volume":"7","author":"Haber","year":"2001","journal-title":"The Neuroscientist"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00076","type":"journal-article","article-title":"Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation","volume":"8","author":"Harris","year":"2014","journal-title":"Frontiers in Neural Circuits"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1038\/nn1544","type":"journal-article","article-title":"The cerebellum communicates with the basal ganglia","volume":"8","author":"Hoshi","year":"2005","journal-title":"Nature Neuroscience"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"7704","DOI":"10.1523\/JNEUROSCI.4694-13.2014","type":"journal-article","article-title":"Achieving high-frequency optical control of synaptic transmission","volume":"34","author":"Jackman","year":"2014","journal-title":"The Journal of Neuroscience"},{"key":"bib21","doi-asserted-by":"publisher","DOI":"10.1038\/srep20072","type":"journal-article","article-title":"Comparative three-dimensional connectome map of motor cortical projections in the mouse brain","volume":"6","author":"Jeong","year":"2016","journal-title":"Scientific Reports"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64665-2","type":"journal-article","article-title":"Anatomically revealed morphological patterns of pyramidal neurons in layer 5 of the motor cortex","volume":"10","author":"Jiang","year":"2020","journal-title":"Scientific Reports"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/cne.1277","type":"journal-article","article-title":"Thalamic terminal morphology and distribution of single corticothalamic axons originating from layers 5 and 6 of the cat motor cortex","volume":"437","author":"Kakei","year":"2001","journal-title":"The Journal of Comparative Neurology"},{"key":"bib24","volume-title":"Principles of Neural Science","author":"Kandel","year":"2020","type":"book"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"5990","DOI":"10.1523\/JNEUROSCI.5717-11.2012","type":"journal-article","article-title":"The subthalamic nucleus is one of multiple innervation sites for long-range corticofugal axons: a single-axon tracing study in the rat","volume":"32","author":"Kita","year":"2012","journal-title":"The Journal of Neuroscience"},{"key":"bib26","first-page":"1","type":"journal-article","article-title":"Morphological variation among corticothalamic terminals implies diverse function of layer 5 projections","volume":"4","author":"Koster","year":"2022","journal-title":"Journal of Life Sciences"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/cne.10539","type":"journal-article","article-title":"Reevaluation of the primary motor cortex connections with the thalamus in primates","volume":"457","author":"Kultas-Ilinsky","year":"2003","journal-title":"The Journal of Comparative Neurology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1460-9568.2010.07481.x","type":"journal-article","article-title":"Complementary distribution of glutamatergic cerebellar and GABAergic basal ganglia afferents to the rat motor thalamic nuclei","volume":"33","author":"Kuramoto","year":"2011","journal-title":"The European Journal of Neuroscience"},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009621","type":"journal-article","article-title":"Functional neuroanatomy of the basal ganglia","volume":"2","author":"Lanciego","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/297406a0","type":"journal-article","article-title":"Electrophysiology of mammalian thalamic neurones in vitro","volume":"297","author":"Llin\u00e1s","year":"1982","journal-title":"Nature"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"8117","DOI":"10.1523\/JNEUROSCI.22-18-08117.2002","type":"journal-article","article-title":"Thalamic relay nuclei of the basal ganglia form both reciprocal and nonreciprocal cortical connections, linking multiple frontal cortical areas","volume":"22","author":"McFarland","year":"2002","journal-title":"The Journal of Neuroscience"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201481119","type":"journal-article","article-title":"Conserved patterns of functional organization between cortex and thalamus in mice","volume":"119","author":"Miller-Hansen","year":"2022","journal-title":"PNAS"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1523\/JNEUROSCI.1467-18.2018","type":"journal-article","article-title":"A sensorimotor pathway via higher-order thalamus","volume":"39","author":"Mo","year":"2019","journal-title":"The Journal of Neuroscience"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"4075","DOI":"10.1073\/pnas.88.10.4075","type":"journal-article","article-title":"Two distinct inputs to an avian song nucleus activate different glutamate receptor subtypes on individual neurons","volume":"88","author":"Mooney","year":"1991","journal-title":"PNAS"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1093\/cercor\/bhs287","type":"journal-article","article-title":"Temporal coupling with cortex distinguishes spontaneous neuronal activities in identified basal ganglia-recipient and cerebellar-recipient zones of the motor thalamus","volume":"24","author":"Nakamura","year":"2014","journal-title":"Cerebral Cortex"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1146\/annurev-neuro-070918-050452","type":"journal-article","article-title":"Basal ganglia circuits for action specification","volume":"43","author":"Park","year":"2020","journal-title":"Annual Review of Neuroscience"},{"key":"bib37","volume-title":"The mouse brain in stereotaxic coordinates","author":"Paxinos","year":"2007","type":"book"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1113\/jphysiol.2012.247619","type":"journal-article","article-title":"Functional significance of synaptic terminal size in glutamatergic sensory pathways in thalamus and cortex","volume":"591","author":"Petrof","year":"2013","journal-title":"The Journal of Physiology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1523\/JNEUROSCI.0529-20.2020","type":"journal-article","article-title":"Layer 5 corticofugal projections from diverse cortical areas: variations on a pattern of thalamic and extrathalamic targets","volume":"40","author":"Prasad","year":"2020","journal-title":"The Journal of Neuroscience"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/s0306-4522(98)00319-4","type":"journal-article","article-title":"The basal ganglia: a vertebrate solution to the selection problem?","volume":"89","author":"Redgrave","year":"1999","journal-title":"Neuroscience"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.neuroscience.2011.07.060","type":"journal-article","article-title":"Functional properties of the basal ganglia\u2019s re-entrant loop architecture: selection and reinforcement","volume":"198","author":"Redgrave","year":"2011","journal-title":"Neuroscience"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/(sici)1096-9861(19980629)396:2<169::aid-cne3>3.0.co;2-z","type":"journal-article","article-title":"Dual morphology and topography of the corticothalamic terminals originating from the primary, supplementary motor, and dorsal premotor cortical areas in macaque monkeys","volume":"396","author":"Rouiller","year":"1998","journal-title":"The Journal of Comparative Neurology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S1472-9288(03)00019-0","type":"journal-article","article-title":"The dual pattern of corticothalamic projection of the premotor cortex in macaque monkeys","volume":"2","author":"Rouiller","year":"2003","journal-title":"Thalamus & Related Systems"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"17894","DOI":"10.1523\/JNEUROSCI.2815-12.2012","type":"journal-article","article-title":"Drivers of the primate thalamus","volume":"32","author":"Rov\u00f3","year":"2012","journal-title":"The Journal of Neuroscience"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/(SICI)1096-9861(19960429)368:2<215::AID-CNE4>3.0.CO;2-6","type":"journal-article","article-title":"Comparison of cerebellothalamic and pallidothalamic projections in the monkey (Macaca fuscata): a double anterograde labeling study","volume":"368","author":"Sakai","year":"1996","journal-title":"The Journal of Comparative Neurology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1113\/JP280455","type":"journal-article","article-title":"Temporal dynamics of the cerebello-cortical convergence in ventro-lateral motor thalamus","volume":"599","author":"Sch\u00e4fer","year":"2021","journal-title":"The Journal of Physiology"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"7121","DOI":"10.1073\/pnas.95.12.7121","type":"journal-article","article-title":"On the actions that one nerve cell can have on another: Distinguishing \u201cdrivers\u201d from \u201cmodulators.\u201d","volume":"95","author":"Sherman","year":"1998","journal-title":"PNAS"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.conb.2007.07.003","type":"journal-article","article-title":"The thalamus is more than just a relay","volume":"17","author":"Sherman","year":"2007","journal-title":"Current Opinion in Neurobiology"},{"key":"bib49","type":"web-resource","article-title":"Exploring the thalamus and its role in cortical function","author":"Sherman","year":"2009","unstructured":"Sherman SM, Guillery RW. 2009. Exploring the thalamus and its role in cortical function. https:\/\/direct.mit.edu\/books\/book\/3000\/exploring-the-thalamus-and-its-role-in-cortical [Accessed February 5, 2024]."},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1152\/jn.00429.2011","type":"journal-article","article-title":"Distinct functions for direct and transthalamic corticocortical connections","volume":"106","author":"Sherman","year":"2011","journal-title":"Journal of Neurophysiology"},{"key":"bib51","type":"web-resource","article-title":"Functional connections of cortical areas","author":"Sherman","year":"2013","unstructured":"Sherman SM, Guillery RW. 2013. Functional connections of cortical areas. https:\/\/direct.mit.edu\/books\/book\/3702 [Accessed February 5, 2024]."},{"key":"bib52","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nn.4269","type":"journal-article","article-title":"Thalamus plays a central role in ongoing cortical functioning","volume":"19","author":"Sherman","year":"2016","journal-title":"Nature Neuroscience"},{"key":"bib53","type":"web-resource","article-title":"The thalamus","author":"Sherman","year":"2022","unstructured":"Sherman MS. 2022. The thalamus. https:\/\/www.cambridge.org\/core\/product\/identifier\/9781108674287\/type\/book [Accessed February 5, 2024]."},{"key":"bib54","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.conb.2003.10.014","type":"journal-article","article-title":"The role of the thalamus in motor control","volume":"13","author":"Sommer","year":"2003","journal-title":"Current Opinion in Neurobiology"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111494","type":"journal-article","article-title":"Transition of distinct context-dependent ensembles from secondary to primary motor cortex in skilled motor performance","volume":"41","author":"Terada","year":"2022","journal-title":"Cell Reports"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nn.2449","type":"journal-article","article-title":"The corticothalamocortical circuit drives higher-order cortex in the mouse","volume":"13","author":"Theyel","year":"2010","journal-title":"Nature Neuroscience"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/cne.24423","type":"journal-article","article-title":"Corticofugal circuits: communication lines from the cortex to the rest of the brain","volume":"527","author":"Usrey","year":"2019","journal-title":"The Journal of Comparative Neurology"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"12738","DOI":"10.1523\/JNEUROSCI.1565-11.2011","type":"journal-article","article-title":"Synaptic properties of thalamic input to the subgranular layers of primary somatosensory and auditory cortices in the mouse","volume":"31","author":"Viaene","year":"2011","journal-title":"The Journal of Neuroscience"},{"key":"bib59","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54474","type":"journal-article","article-title":"Control of adaptive action selection by secondary motor cortex during flexible visual categorization","volume":"9","author":"Wang","year":"2020","journal-title":"eLife"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.cell.2019.07.042","type":"journal-article","article-title":"Reconstruction of 1,000 projection neurons reveals new cell types and organization of long-range connectivity in the mouse brain","volume":"179","author":"Winnubst","year":"2019","journal-title":"Cell"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/97489\/elife-97489-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/97489\/elife-97489-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/97489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:28:05Z","timestamp":1787567285000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/97489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":60,"alternative-id":["10.7554\/eLife.97489"],"URL":"https:\/\/doi.org\/10.7554\/elife.97489","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.03.14.584958","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2024.03.14.584958","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.97489.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.97489.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.97489.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,10]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e97489"}}