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Here, we confirm that TNF signaling hampers physical activity, food intake, and energy expenditure while enhancing glucose uptake by the liver and spleen, as well as controlling parasitemia in\n                    <jats:italic>Plasmodium chabaudi<\/jats:italic>\n                    (\n                    <jats:italic>Pc<\/jats:italic>\n                    )-infected mice. We also report that TNF is required for expression of inducible nitric oxide synthase (iNOS), stabilization of hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1), expression of glucose transporter GLUT1, and enhanced glycolysis in monocytic cells from\n                    <jats:italic>Pc<\/jats:italic>\n                    -infected mice. Importantly,\n                    <jats:italic>Pc<\/jats:italic>\n                    -infected\n                    <jats:italic>Nos2<\/jats:italic>\n                    <jats:sup>-\/-<\/jats:sup>\n                    , TNFR1 cKO, and HIF-1a cKO mice show impaired release of TNF and glycolysis in monocytes, along with increased parasitemia and disease tolerance. Altogether, our results indicate that TNF-iNOS-HIF-1\u03b1-induced glycolysis in monocytes plays a critical role in host defense and sickness behavior in\n                    <jats:italic>Pc<\/jats:italic>\n                    -infected mice.\n                  <\/jats:p>","DOI":"10.7554\/elife.97759","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T07:25:24Z","timestamp":1721201124000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.97759","source":"Crossref","is-referenced-by-count":0,"title":["Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1\u03b1 axis plays a key role in host resistance to Plasmodium infection"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-1837","authenticated-orcid":true,"given":"Kely Catarine","family":"Matteucci","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"Translational Medicine Platform Oswaldo Cruz Foundation, Ribeir\u00e3o Preto Medical School, University of Sao Paulo","place":["S\u00e3o Paulo, Brazil"]},{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry and Immunology, Ribeir\u00e3o Preto Medical School, University of Sao Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0275-2949","authenticated-orcid":true,"given":"Nathalia PS","family":"Leite","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"Translational Medicine Platform Oswaldo Cruz Foundation, Ribeir\u00e3o Preto Medical School, University of Sao Paulo","place":["S\u00e3o Paulo, Brazil"]},{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry and Immunology, Ribeir\u00e3o Preto Medical School, University of Sao Paulo","place":["S\u00e3o Paulo, Brazil"]},{"id":[{"id":"https:\/\/ror.org\/0176yjw32","id-type":"ROR","asserted-by":"publisher"}],"name":"Technology Center for Vaccines, Federal University of Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Patricia A","family":"Assis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00jmfr291","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, University of Michigan Medical School","place":["Ann Arbor, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Isabella Cristina","family":"Hirako","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04jhswv08","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Immunopathology, Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz - 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