{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:07:47Z","timestamp":1792202867661,"version":"4.4.0"},"reference-count":47,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019491","name":"National Natural Science Foundation of China - State Grid Corporation Joint Fund for Smart Grid","doi-asserted-by":"publisher","award":["3220889"],"award-info":[{"award-number":["3220889"]}],"id":[{"id":"10.13039\/501100019491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019491","name":"National Natural Science Foundation of China - State Grid Corporation Joint Fund for Smart Grid","doi-asserted-by":"publisher","award":["31972749"],"award-info":[{"award-number":["31972749"]}],"id":[{"id":"10.13039\/501100019491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["2022010304JC"],"award-info":[{"award-number":["2022010304JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Gout is a prevalent form of inflammatory arthritis that occurs due to high levels of uric acid in the blood leading to the formation of urate crystals in and around the joints, particularly affecting the elderly. Recent research has provided evidence of distinct differences in the gut microbiota of patients with gout and hyperuricemia compared to healthy individuals. However, the link between gut microbiota and age-related gout remained underexplored. Our study found that gut microbiota plays a crucial role in determining susceptibility to age-related gout. Specifically, we observed that age-related gut microbiota regulated the activation of the NLRP3 inflammasome pathway and modulated uric acid metabolism. More scrutiny highlighted the positive impact of \u2018younger\u2019 microbiota on the gut microbiota structure of old or aged mice, enhancing butanoate metabolism and butyric acid content. Experimentation with butyrate supplementation indicated that butyric acid exerts a dual effect, inhibiting inflammation in acute gout and reducing serum uric acid levels. These insights emphasize the potential of gut microbiome rejuvenation in mitigating senile gout, unraveling the intricate dynamics between microbiota, aging, and gout. It potentially serves as a therapeutic target for senile gout-related conditions.<\/jats:p>","DOI":"10.7554\/elife.98714","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T11:25:06Z","timestamp":1721042706000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.98714","source":"Crossref","is-referenced-by-count":7,"title":["Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice"],"prefix":"10.7554","volume":"13","author":[{"given":"Ning","family":"Song","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00js3aw79","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Hang","family":"Gao","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034haf133","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Bone and Joint Surgery, No 1 Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Jianhao","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00js3aw79","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034haf133","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Bone and Joint Surgery, No 1 Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Mingze","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00js3aw79","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Zhiming","family":"Ma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03x6hbh34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Naisheng","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00js3aw79","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-2241","authenticated-orcid":true,"given":"Wenlong","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00js3aw79","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","type":"journal-article","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/s41591-019-0504-5","type":"journal-article","article-title":"Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice","volume":"25","author":"B\u00e1rcena","year":"2019","journal-title":"Nature Medicine"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/s43587-021-00093-9","type":"journal-article","article-title":"Microbiota from young mice counteracts selective age-associated behavioral deficits","volume":"1","author":"Boehme","year":"2021","journal-title":"Nature Aging"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1093\/gerona\/glaa103","type":"journal-article","article-title":"The gut microbiome and aging","volume":"75","author":"Buford","year":"2020","journal-title":"The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ebiom.2018.03.030","type":"journal-article","article-title":"Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a tnbs-induced inflammatory bowel disease mice model","volume":"30","author":"Chen","year":"2018","journal-title":"EBioMedicine"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0762-4","type":"journal-article","article-title":"Factors influencing the crystallization of monosodium urate: a systematic literature review","volume":"16","author":"Chhana","year":"2015","journal-title":"BMC Musculoskeletal Disorders"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-021-00235-2","type":"journal-article","article-title":"Metagenomic analysis revealed the potential role of gut microbiome in gout","volume":"7","author":"Chu","year":"2021","journal-title":"NPJ Biofilms and Microbiomes"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1016\/S0140-6736(16)00346-9","type":"journal-article","article-title":"Stamp: gout","volume":"388","author":"Dalbeth","year":"2016","journal-title":"Lancet"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1099\/ijs.0.02873-0","type":"journal-article","article-title":"a human intestinal mucin-degrading bacterium","volume":"54","author":"Derrien","year":"2004","journal-title":"International Journal of Systematic and Evolutionary Microbiology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/B978-0-12-822405-2.00006-2","type":"journal-article","article-title":"Health and disease: gut microbiota on human health and disease","volume":"01","author":"Duttaroy","year":"2021","journal-title":"CoLab"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41575-022-00605-x","type":"journal-article","article-title":"The gut microbiome as a modulator of healthy ageing","volume":"19","author":"Ghosh","year":"2022","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1016\/j.celrep.2017.02.004","type":"journal-article","article-title":"\u03b2-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares","volume":"18","author":"Goldberg","year":"2017","journal-title":"Cell Reports"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1038\/srep20602","type":"journal-article","article-title":"Intestinal microbiota distinguish gout patients from healthy humans","volume":"6","author":"Guo","year":"2016","journal-title":"Scientific Reports"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1101\/gr.112730.110","type":"journal-article","article-title":"Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons","volume":"21","author":"Haas","year":"2011","journal-title":"Genome Research"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.chom.2023.05.011","type":"journal-article","article-title":"Gut bacterial metabolism contributes to host global purine homeostasis","volume":"31","author":"Kasahara","year":"2023","journal-title":"Cell Host & Microbe"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01386-w","type":"journal-article","article-title":"Gut microbiota of the young ameliorates physical fitness of the aged in mice","volume":"10","author":"Kim","year":"2022","journal-title":"Microbiome"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1161\/CIRCRESAHA.119.316448","type":"journal-article","article-title":"Gut microbiota-derived short-chain fatty acids promote poststroke recovery in aged mice","volume":"127","author":"Lee","year":"2020","journal-title":"Circulation Research"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"755","DOI":"10.21147\/j.issn.1000-9604.2020.06.09","type":"journal-article","article-title":"Signatures within esophageal microbiota with progression of esophageal squamous cell carcinoma","volume":"32","author":"Li","year":"2020","journal-title":"Chinese Journal of Cancer Research = Chung-Kuo Yen Cheng Yen Chiu"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1968257","type":"journal-article","article-title":"Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease","volume":"13","author":"Li","year":"2021","journal-title":"Gut Microbes"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"3400","DOI":"10.1016\/j.cell.2023.06.010","type":"journal-article","article-title":"A widely distributed gene cluster compensates for uricase loss in hominids","volume":"186","author":"Liu","year":"2023","journal-title":"Cell"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1056\/NEJMra1600266","type":"journal-article","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch","year":"2016","journal-title":"The New England Journal of Medicine"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","type":"journal-article","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Mago\u010d","year":"2011","journal-title":"Bioinformatics"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.7150\/thno.40650","type":"journal-article","article-title":"A mouse model of MSU-induced acute inflammation in vivo suggests imiquimod-dependent targeting of Il-1\u03b2 as relevant therapy for gout patients","volume":"10","author":"Mariotte","year":"2020","journal-title":"Theranostics"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature04516","type":"journal-article","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00296-021-05007-x","type":"journal-article","article-title":"Uric acid extrarenal excretion: the gut microbiome as an evident yet understated factor in gout development","volume":"42","author":"M\u00e9ndez-Salazar","year":"2022","journal-title":"Rheumatology International"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.1080\/10408398.2018.1494539","type":"journal-article","article-title":"Anti-proliferative, pro-apoptotic and anti-oxidative activity of Lactobacillus and Bifidobacterium strains: a review of mechanisms and therapeutic perspectives","volume":"59","author":"Nowak","year":"2019","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.apsb.2019.10.007","type":"journal-article","article-title":"Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia","volume":"10","author":"Pan","year":"2020","journal-title":"Acta Pharmaceutica Sinica. B"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01243-w","type":"journal-article","article-title":"Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain","volume":"10","author":"Parker","year":"2022","journal-title":"Microbiome"},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnv176","type":"journal-article","article-title":"Enhanced butyrate formation by cross-feeding between Faecalibacterium prausnitzii and Bifidobacterium adolescentis","volume":"362","author":"Rios-Covian","year":"2015","journal-title":"FEMS Microbiology Letters"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1080\/10408398.2014.887055","type":"journal-article","article-title":"Probiotics, prebiotics, and microencapsulation: a review","volume":"57","author":"Sarao","year":"2017","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nm.3547","type":"journal-article","article-title":"Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines","volume":"20","author":"Schauer","year":"2014","journal-title":"Nature Medicine"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"591","DOI":"10.2165\/11592750-000000000-00000","type":"journal-article","article-title":"The challenges of gout management in the elderly","volume":"28","author":"Stamp","year":"2011","journal-title":"Drugs & Aging"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00268","type":"journal-article","article-title":"Chengping","volume":"8","author":"Tiejuan","year":"2017","journal-title":"Combined Signature of the Fecal Microbiome and Metabolome in Patients with Gout"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3920\/BM2015.0015","type":"journal-article","article-title":"Oral treatment with Bifidobacterium longum 51A reduced inflammation in a murine experimental model of gout","volume":"6","author":"Vieira","year":"2015","journal-title":"Beneficial Microbes"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"858","DOI":"10.3390\/nu3100858","type":"journal-article","article-title":"Regulation of inflammation by short chain fatty acids","volume":"3","author":"Vinolo","year":"2011","journal-title":"Nutrients"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nprot.2012.135","type":"journal-article","article-title":"Global metabolic profiling of animal and human tissues via UPLC-MS","volume":"8","author":"Want","year":"2013","journal-title":"Nature Protocols"},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1579-y","type":"journal-article","article-title":"metaX: a flexible and comprehensive software for processing metabolomics data","volume":"18","author":"Wen","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1080\/15257770.2015.1125000","type":"journal-article","article-title":"Evaluation of purine utilization by Lactobacillus gasseri strains with potential to decrease the absorption of food-derived purines in the human intestine","volume":"35","author":"Yamada","year":"2016","journal-title":"Nucleosides, Nucleotides & Nucleic Acids"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/rheumatology\/kex499","type":"journal-article","article-title":"Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation","volume":"57","author":"Yang","year":"2018","journal-title":"Rheumatology"},{"key":"bib40","volume-title":"Higher infl ammatory response in elderly patients dring gout 777 attack","author":"Yang","year":"2024","type":"book"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1398913","type":"journal-article","article-title":"Gut microbiota-derived acetate promotes long-term recovery through angiogenesis guided by lymphatic ingrowth in older adults with stroke","volume":"18","author":"Yuan","year":"2024","journal-title":"Frontiers in Neuroscience"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1111\/1751-7915.13410","type":"journal-article","article-title":"Akkermansia muciniphila is a promising probiotic","volume":"12","author":"Zhang","year":"2019","journal-title":"Microbial Biotechnology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.tem.2020.12.003","type":"journal-article","article-title":"Butyrate in energy metabolism: there is still more to learn","volume":"32","author":"Zhang","year":"2021","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"12412","DOI":"10.1039\/D2FO02702J","type":"journal-article","article-title":"Live and pasteurized Akkermansia muciniphila attenuate hyperuricemia in mice through modulating uric acid metabolism, inflammation, and gut microbiota","volume":"13","author":"Zhang","year":"2022","journal-title":"Food & Function"},{"key":"bib45","doi-asserted-by":"publisher","DOI":"10.1128\/aem.01019-23","type":"journal-article","article-title":"Lactate cross-feeding between Bifidobacterium species and Megasphaera indica contributes to butyrate formation in the human colonic environment","volume":"90","author":"Zhao","year":"2024","journal-title":"Applied and Environmental Microbiology"},{"key":"dataset1","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.27986510","type":"dataset","article-title":"The original uncropped image of the immunoblot in the article","volume-title":"figshare","author":"Wenlong","year":"2024","unstructured":"Wenlong Z. 2024. The original uncropped image of the immunoblot in the article. figshare."},{"key":"dataset2","doi-asserted-by":"publisher","DOI":"10.26036\/CNP0004751","type":"dataset","article-title":"Gut microbiota transplantation from young to aged mice mitigates senile gout","volume-title":"CNGB Sequence Archive","author":"Song","year":"2025","unstructured":"Song N. 2025. Gut microbiota transplantation from young to aged mice mitigates senile gout. CNGB Sequence Archive."}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/98714\/elife-98714-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/98714\/elife-98714-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/98714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:55:14Z","timestamp":1787565314000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/98714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":47,"alternative-id":["10.7554\/eLife.98714"],"URL":"https:\/\/doi.org\/10.7554\/elife.98714","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.04.22.590443","asserted-by":"subject"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.98714.4","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.98714.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.98714.2","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.98714.3","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.27986510","asserted-by":"subject"},{"id-type":"doi","id":"10.26036\/CNP0004751","asserted-by":"subject"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP98714"}}