{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T18:32:39Z","timestamp":1792348359500,"version":"4.4.0"},"reference-count":54,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2021-NR058319"],"award-info":[{"award-number":["RS-2021-NR058319"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002512","name":"Kookmin University","doi-asserted-by":"publisher","award":["Global Scholarship Program for Foreign Graduate Students"],"award-info":[{"award-number":["Global Scholarship Program for Foreign Graduate Students"]}],"id":[{"id":"10.13039\/501100002512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003654","name":"Korea Environmental Industry and Technology Institute","doi-asserted-by":"publisher","award":["Biomaterials Specialized Graduate Program"],"award-info":[{"award-number":["Biomaterials Specialized Graduate Program"]}],"id":[{"id":"10.13039\/501100003654","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Understanding how the brain controls nutrient storage is pivotal. Transient receptor potential (TRP) channels are conserved from insects to humans. They serve in detecting environmental shifts and in acting as internal sensors. Previously, we demonstrated the role of TRP\u03b3 in nutrient-sensing behavior (Dhakal et al., 2022). Here, we found that a TRP\u03b3 mutant exhibited in\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    is required for maintaining normal lipid and protein levels. In animals, lipogenesis and lipolysis control lipid levels in response to food availability. Lipids are mostly stored as triacylglycerol in the fat bodies (FBs) of\n                    <jats:italic>D. melanogaster<\/jats:italic>\n                    . Interestingly,\n                    <jats:italic>trp\u03b3<\/jats:italic>\n                    deficient mutants exhibited elevated TAG levels and our genetic data indicated that\n                    <jats:italic>Dh44<\/jats:italic>\n                    neurons are indispensable for normal lipid storage but not protein storage. The\n                    <jats:italic>trp\u03b3<\/jats:italic>\n                    mutants also exhibited reduced starvation resistance, which was attributed to insufficient lipolysis in the FBs. This could be mitigated by administering lipase or metformin orally, indicating a potential treatment pathway. Gene expression analysis indicated that\n                    <jats:italic>trp\u03b3<\/jats:italic>\n                    knockout downregulated\n                    <jats:italic>brummer<\/jats:italic>\n                    , a key lipolytic gene, resulting in chronic lipolytic deficits in the gut and other fat tissues. The study also highlighted the role of specific proteins, including neuropeptide DH44 and its receptor DH44R2 in lipid regulation. Our findings provide insight into the broader question of how the brain and gut regulate nutrient storage.\n                  <\/jats:p>","DOI":"10.7554\/elife.99258","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T14:25:20Z","timestamp":1721139920000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.99258","source":"Crossref","is-referenced-by-count":5,"title":["TRP\u03b3 regulates lipid metabolism through Dh44 neuroendocrine cells"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6105-6970","authenticated-orcid":true,"given":"Dharmendra Kumar","family":"Nath","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0049erg63","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Bio and Fermentation Convergence Technology, Kookmin University","place":["Seoul, Republic of 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