{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:35:12Z","timestamp":1787567712154,"version":"build-2736575974"},"reference-count":99,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016257","name":"University of California Davis","doi-asserted-by":"publisher","award":["R03-TR004200"],"award-info":[{"award-number":["R03-TR004200"]}],"id":[{"id":"10.13039\/100016257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35-NS127216"],"award-info":[{"award-number":["R35-NS127216"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R25-NS063307"],"award-info":[{"award-number":["R25-NS063307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03-TR004200"],"award-info":[{"award-number":["R03-TR004200"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    KvS proteins are voltage-gated potassium channel subunits that form functional channels when assembled into heteromers with Kv2.1 (\n                    <jats:italic>KCNB1<\/jats:italic>\n                    ) or Kv2.2 (\n                    <jats:italic>KCNB2<\/jats:italic>\n                    ). Mammals have 10 KvS subunits: Kv5.1 (\n                    <jats:italic>KCNF1<\/jats:italic>\n                    ), Kv6.1 (\n                    <jats:italic>KCNG1<\/jats:italic>\n                    ), Kv6.2 (\n                    <jats:italic>KCNG2<\/jats:italic>\n                    ), Kv6.3 (\n                    <jats:italic>KCNG3<\/jats:italic>\n                    ), Kv6.4 (\n                    <jats:italic>KCNG4<\/jats:italic>\n                    ), Kv8.1 (\n                    <jats:italic>KCNV1<\/jats:italic>\n                    ), Kv8.2 (\n                    <jats:italic>KCNV2<\/jats:italic>\n                    ), Kv9.1 (\n                    <jats:italic>KCNS1<\/jats:italic>\n                    ), Kv9.2 (\n                    <jats:italic>KCNS2<\/jats:italic>\n                    ), and Kv9.3 (\n                    <jats:italic>KCNS3<\/jats:italic>\n                    ). Electrically excitable cells broadly express channels containing Kv2 subunits and most neurons have substantial Kv2 conductance. However, whether KvS subunits contribute to these conductances has not been clear, leaving the physiological roles of KvS subunits poorly understood. Here, we identify that two potent Kv2 inhibitors, used in combination, can distinguish conductances of Kv2\/KvS heteromers and Kv2-only channels. We find that Kv5, Kv6, Kv8, or Kv9-containing channels are resistant to the Kv2-selective pore-blocker RY785 yet remain sensitive to the Kv2-selective voltage sensor modulator guangxitoxin-1E (GxTX). Using these inhibitors in mouse superior cervical ganglion neurons, we find predominantly RY785-sensitive conductances consistent with channels composed entirely of Kv2 subunits. In contrast, RY785-resistant but GxTX-sensitive conductances consistent with Kv2\/KvS heteromeric channels predominate in mouse and human dorsal root ganglion neurons. These results establish an approach to pharmacologically distinguish conductances of Kv2\/KvS heteromers from Kv2-only channels, enabling investigation of the physiological roles of endogenous KvS subunits. These findings suggest that drugs which distinguish KvS subunits could modulate electrical activity of subsets of Kv2-expressing cell types.\n                  <\/jats:p>","DOI":"10.7554\/elife.99410","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T09:25:57Z","timestamp":1720689957000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.99410","source":"Crossref","is-referenced-by-count":5,"title":["A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2\/KvS heteromers"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5407-0346","authenticated-orcid":true,"given":"Robert G","family":"Stewart","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology and Membrane Biology, University of California Davis","place":["Davis, United States"]},{"id":[{"id":"https:\/\/ror.org\/046dg4z72","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology Course, Marine Biological Laboratory","place":["Woods Hole, United States"]},{"name":"Department of Neurobiology, Harvard Medical School","place":["Boston, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-9072","authenticated-orcid":true,"given":"Matthew James","family":"Marquis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology and Membrane Biology, University of California Davis","place":["Davis, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Sooyeon","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Harvard Medical School","place":["Boston, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3894-0180","authenticated-orcid":true,"given":"Brandon J","family":"Harris","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology and Membrane Biology, University of California Davis","place":["Davis, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4805-541X","authenticated-orcid":true,"given":"Aman S","family":"Aberra","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046dg4z72","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology Course, Marine Biological Laboratory","place":["Woods Hole, United States"]},{"id":[{"id":"https:\/\/ror.org\/049s0rh22","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Sciences, Dartmouth College","place":["Hanover, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Verity","family":"Cook","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046dg4z72","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology Course, Marine Biological Laboratory","place":["Woods Hole, United States"]},{"id":[{"id":"https:\/\/ror.org\/001w7jn25","id-type":"ROR","asserted-by":"publisher"}],"name":"Einstein Center for Neuroscience, Charit\u00e9 Universit\u00e4tsmedizin Berlin","place":["Hufelandweg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Zachary","family":"Whiddon","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046dg4z72","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology Course, Marine Biological Laboratory","place":["Woods Hole, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2325-4834","authenticated-orcid":true,"given":"Vladimir","family":"Yarov-Yarovoy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology and Membrane Biology, University of California Davis","place":["Davis, United States"]},{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Anesthesiology and Pain Medicine, University of California Davis","place":["Davis, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-3024","authenticated-orcid":true,"given":"Michael","family":"Ferns","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology and Membrane Biology, University of California Davis","place":["Davis, United States"]},{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Anesthesiology and Pain Medicine, University of California Davis","place":["Davis, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6975-982X","authenticated-orcid":true,"given":"Jon T","family":"Sack","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology and Membrane Biology, University of California Davis","place":["Davis, United States"]},{"id":[{"id":"https:\/\/ror.org\/046dg4z72","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology Course, Marine Biological Laboratory","place":["Woods Hole, United States"]},{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Anesthesiology and Pain Medicine, University of California Davis","place":["Davis, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1111\/j.1460-9568.2009.07026.x","type":"journal-article","article-title":"Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia","volume":"30","author":"Aras","year":"2009","journal-title":"The European Journal of Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"14922","DOI":"10.1523\/JNEUROSCI.1897-15.2015","type":"journal-article","article-title":"Distinct cell- and layer-specific expression patterns and independent regulation of kv2 channel subtypes in cortical pyramidal neurons","volume":"35","author":"Bishop","year":"2015","journal-title":"The Journal of Neuroscience"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"C1271","DOI":"10.1152\/ajpcell.00088.2009","type":"journal-article","article-title":"Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons","volume":"296","author":"Bocksteins","year":"2009","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037143","type":"journal-article","article-title":"The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1\/Kv6.4 heterotetrameric channels","volume":"7","author":"Bocksteins","year":"2012","journal-title":"PLOS ONE"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1152\/physiol.00023.2011","type":"journal-article","article-title":"Electrically silent Kv subunits: their molecular and functional characteristics","volume":"27","author":"Bocksteins","year":"2012","journal-title":"Physiology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1085\/jgp.201511507","type":"journal-article","article-title":"Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders","volume":"147","author":"Bocksteins","year":"2016","journal-title":"The Journal of General Physiology"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1038\/srep41646","type":"journal-article","article-title":"Independent movement of the voltage sensors in KV2.1\/KV6.4 heterotetramers","volume":"7","author":"Bocksteins","year":"2017","journal-title":"Scientific Reports"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"6183","DOI":"10.1021\/acs.jcim.3c01153","type":"journal-article","article-title":"AmberTools","volume":"63","author":"Case","year":"2023","journal-title":"Journal of Chemical Information and Modeling"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"4652","DOI":"10.1523\/JNEUROSCI.17-12-04652.1997","type":"journal-article","article-title":"Identification and functional characterization of a K+ channel alpha-subunit with regulatory properties specific to brain","volume":"17","author":"Castellano","year":"1997","journal-title":"The Journal of Neuroscience"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.1749-6632.1999.tb11293.x","type":"journal-article","article-title":"Molecular diversity of K+ channels","volume":"868","author":"Coetzee","year":"1999","journal-title":"Annals of the New York Academy of Sciences"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1469-7793.2000.t01-2-00019.xm","type":"journal-article","article-title":"Frequency-dependent regulation of rat hippocampal somato-dendritic excitability by the K+ channel subunit Kv2.1","volume":"522 Pt 1","author":"Du","year":"2000","journal-title":"The Journal of Physiology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/s41586-023-06582-8","type":"journal-article","article-title":"Inactivation of the Kv2.1 channel through electromechanical coupling","volume":"622","author":"Fern\u00e1ndez-Mari\u00f1o","year":"2023","journal-title":"Nature"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2293-23.2025","type":"journal-article","article-title":"The electrically silent kv5.1 subunit forms heteromeric kv2 channels in cortical neurons and confers distinct functional properties","volume":"45","author":"Ferns","year":"2025","journal-title":"The Journal of Neuroscience"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nature02033","type":"journal-article","article-title":"A gene expression atlas of the central nervous system based on bacterial artificial chromosomes","volume":"425","author":"Gong","year":"2003","journal-title":"Nature"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1124\/pr.57.4.10","type":"journal-article","article-title":"International Union of Pharmacology","volume":"57","author":"Gutman","year":"2005","journal-title":"Pharmacological Reviews"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<490::AID-JCC1>3.0.CO;2-P","type":"journal-article","article-title":"Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94","volume":"17","author":"Halgren","year":"1996","journal-title":"Journal of Computational Chemistry"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<553::AID-JCC3>3.0.CO;2-T","type":"journal-article","article-title":"Merck molecular force field. III. Molecular geometries and vibrational frequencies for MMFF94","volume":"17","author":"Halgren","year":"1996","journal-title":"Journal of Computational Chemistry"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<616::AID-JCC5>3.0.CO;2-X","type":"journal-article","article-title":"Merck molecular force field. V. Extension of MMFF94 using experimental data, additional computational data, and empirical rules","volume":"17","author":"Halgren","year":"1996","journal-title":"Journal of Computational Chemistry"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<520::AID-JCC2>3.0.CO;2-W","type":"journal-article","article-title":"Merck molecular force field. II. MMFF94 van der Waals and electrostatic parameters for intermolecular interactions","volume":"17","author":"Halgren","year":"1996","journal-title":"Journal of Computational Chemistry"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<587::AID-JCC4>3.0.CO;2-Q","type":"journal-article","article-title":"Merck molecular force field. IV. conformational energies and geometries for MMFF94","volume":"17","author":"Halgren","year":"1996","journal-title":"Journal of Computational Chemistry"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/(SICI)1096-987X(199905)20:7<720::AID-JCC7>3.0.CO;2-X","type":"journal-article","article-title":"MMFF VI. MMFF94s option for energy minimization studies","volume":"20","author":"Halgren","year":"1999","journal-title":"Journal of Computational Chemistry"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/(SICI)1096-987X(199905)20:7<730::AID-JCC8>3.0.CO;2-T","type":"journal-article","article-title":"MMFF VII. Characterization of MMFF94, MMFF94s, and other widely available force fields for conformational energies and for intermolecular-interaction energies and geometries","volume":"20","author":"Halgren","year":"1999","journal-title":"Journal of Computational Chemistry"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-4-17","type":"journal-article","article-title":"Avogadro: an advanced semantic chemical editor, visualization, and analysis platform","volume":"4","author":"Hanwell","year":"2012","journal-title":"Journal of Cheminformatics"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1411428","type":"journal-article","article-title":"Toward high-resolution modeling of small molecule-ion channel interactions","volume":"15","author":"Harris","year":"2024","journal-title":"Frontiers in Pharmacology"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0032-19.2019","type":"journal-article","article-title":"The role of the voltage-gated potassium channel proteins kv8.2 and kv2.1 in vision and retinal disease: insights from the study of mouse gene knock-out mutations","volume":"6","author":"Hart","year":"2019","journal-title":"eNeuro"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.2174\/0929867043363820","type":"journal-article","article-title":"Dendrotoxins: structure-activity relationships and effects on potassium ion channels","volume":"11","author":"Harvey","year":"2004","journal-title":"Current Medicinal Chemistry"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.2337\/diabetes.55.04.06.db05-0788","type":"journal-article","article-title":"Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion","volume":"55","author":"Herrington","year":"2006","journal-title":"Diabetes"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1124\/mol.111.074831","type":"journal-article","article-title":"Identification of novel and selective Kv2 channel inhibitors","volume":"80","author":"Herrington","year":"2011","journal-title":"Molecular Pharmacology"},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae202","type":"journal-article","article-title":"Downregulation of the silent potassium channel Kv8.1 increases motor neuron vulnerability in amyotrophic lateral sclerosis","volume":"6","author":"Huang","year":"2024","journal-title":"Brain Communications"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1093\/hmg\/ddab301","type":"journal-article","article-title":"Differential impact of Kv8.2 loss on rod and cone signaling and degeneration","volume":"31","author":"Inamdar","year":"2022","journal-title":"Human Molecular Genetics"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"8520","DOI":"10.1073\/pnas.0611364104","type":"journal-article","article-title":"A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat","volume":"104","author":"Jarvis","year":"2007","journal-title":"PNAS"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2407461121","type":"journal-article","article-title":"A broad survey of choanoflagellates revises the evolutionary history of the Shaker family of voltage-gated K+ channels in animals","volume":"121","author":"Jegla","year":"2024","journal-title":"PNAS"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"E7331","DOI":"10.1073\/pnas.1805757115","type":"journal-article","article-title":"Kv2 potassium channels form endoplasmic reticulum\/plasma membrane junctions via interaction with VAPA and VAPB","volume":"115","author":"Johnson","year":"2018","journal-title":"PNAS"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"5443","DOI":"10.1073\/pnas.1017539108","type":"journal-article","article-title":"Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility","volume":"108","author":"Jorge","year":"2011","journal-title":"PNAS"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S0006-3495(99)76886-4","type":"journal-article","article-title":"Heteromeric assembly of Kv2.1 with Kv9.3: effect on the state dependence of inactivation","volume":"77","author":"Kerschensteiner","year":"1999","journal-title":"Biophysical Journal"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","type":"journal-article","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2023","journal-title":"Nucleic Acids Research"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1091\/mbc.E18-05-0337","type":"journal-article","article-title":"Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels","volume":"29","author":"Kirmiz","year":"2018","journal-title":"Molecular Biology of the Cell"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1085\/jgp.201812251","type":"journal-article","article-title":"Oddballs in the Shaker family: Kv2-related regulatory subunits","volume":"150","author":"Kobertz","year":"2018","journal-title":"The Journal of General Physiology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"C1501","DOI":"10.1152\/ajpcell.1998.274.6.C1501","type":"journal-article","article-title":"Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits","volume":"274","author":"Kramer","year":"1998","journal-title":"The American Journal of Physiology"},{"key":"bib40","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107941","type":"journal-article","article-title":"Human labor pain is influenced by the voltage-gated potassium channel KV6.4 Subunit","volume":"32","author":"Lee","year":"2020","journal-title":"Cell Reports"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1124\/jpet.112.199083","type":"journal-article","article-title":"The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets","volume":"344","author":"Li","year":"2013","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"4991","DOI":"10.1523\/JNEUROSCI.1925-13.2014","type":"journal-article","article-title":"Kv2 channel regulation of action potential repolarization and firing patterns in superior cervical ganglion neurons and hippocampal CA1 pyramidal neurons","volume":"34","author":"Liu","year":"2014","journal-title":"The Journal of Neuroscience"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.cell.2016.03.014","type":"journal-article","article-title":"On the dependency of cellular protein levels on mrna abundance","volume":"165","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/s0896-6273(02)00714-6","type":"journal-article","article-title":"Molecular basis of an inherited epilepsy","volume":"34","author":"Lossin","year":"2002","journal-title":"Neuron"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1113\/jphysiol.2012.248831","type":"journal-article","article-title":"Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels","volume":"591","author":"Maffie","year":"2013","journal-title":"The Journal of Physiology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"F257","DOI":"10.1152\/ajprenal.00048.2020","type":"journal-article","article-title":"Urinary bladder smooth muscle ion channels: expression, function, and regulation in health and disease","volume":"319","author":"Malysz","year":"2020","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"bib47","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1403.3640","type":"preprint","article-title":"A New Open Source Software for the Calculation of the Liquid Junction Potential between Two Solutions According to the Stationary Nernst-Planck Equation","volume-title":"arXiv","author":"Marino.M","year":"2014"},{"key":"bib48","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202112981","type":"journal-article","article-title":"Mechanism of use-dependent Kv2 channel inhibition by RY785","volume":"154","author":"Marquis","year":"2022","journal-title":"The Journal of General Physiology"},{"key":"bib49","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05527-1","type":"journal-article","article-title":"The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes","volume":"6","author":"Matsumoto","year":"2023","journal-title":"Communications Biology"},{"key":"bib50","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.256339","type":"journal-article","article-title":"Kv2 channel-AMIGO \u03b2-subunit assembly modulates both channel function and cell adhesion molecule surface trafficking","volume":"134","author":"Maverick","year":"2021","journal-title":"Journal of Cell Science"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1038\/nsmb.1679","type":"journal-article","article-title":"Interactions between lipids and voltage sensor paddles detected with tarantula toxins","volume":"16","author":"Milescu","year":"2009","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1085\/jgp.201210914","type":"journal-article","article-title":"Opening the shaker K+ channel with hanatoxin","volume":"141","author":"Milescu","year":"2013","journal-title":"The Journal of General Physiology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","type":"journal-article","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nature Methods"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"11184","DOI":"10.1523\/JNEUROSCI.3370-05.2005","type":"journal-article","article-title":"Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia","volume":"25","author":"Misonou","year":"2005","journal-title":"The Journal of Neuroscience"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"13505","DOI":"10.1523\/JNEUROSCI.3970-06.2006","type":"journal-article","article-title":"Bidirectional activity-dependent regulation of neuronal ion channel phosphorylation","volume":"26","author":"Misonou","year":"2006","journal-title":"The Journal of Neuroscience"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"8529","DOI":"10.1523\/JNEUROSCI.1417-08.2008","type":"journal-article","article-title":"Dynamic regulation of the Kv2.1 voltage-gated potassium channel during brain ischemia through neuroglial interaction","volume":"28","author":"Misonou","year":"2008","journal-title":"The Journal of Neuroscience"},{"key":"bib57","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105382","type":"journal-article","article-title":"Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia","volume":"155","author":"Miyamae","year":"2021","journal-title":"Neurobiology of Disease"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1124\/mol.52.5.821","type":"journal-article","article-title":"Phosphorylation of the Kv2.1 K+ channel alters voltage-dependent activation","volume":"52","author":"Murakoshi","year":"1997","journal-title":"Molecular Pharmacology"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1021\/acs.jctc.0c01184","type":"journal-article","article-title":"Force Field Optimization Guided by Small Molecule Crystal Lattice Data Enables Consistent Sub-Angstrom Protein-Ligand Docking","volume":"17","author":"Park","year":"2021","journal-title":"Journal of Chemical Theory and Computation"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1152\/jn.01028.2015","type":"journal-article","article-title":"Roles of specific Kv channel types in repolarization of the action potential in genetically identified subclasses of pyramidal neurons in mouse neocortex","volume":"115","author":"Pathak","year":"2016","journal-title":"Journal of Neurophysiology"},{"key":"bib61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008103","type":"journal-article","article-title":"Efficient consideration of coordinated water molecules improves computational protein-protein and protein-ligand docking discrimination","volume":"16","author":"Pavlovicz","year":"2020","journal-title":"PLOS Computational Biology"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1038\/embor.2011.204","type":"journal-article","article-title":"AMIGO is an auxiliary subunit of the Kv2.1 potassium channel","volume":"12","author":"Peltola","year":"2011","journal-title":"EMBO Reports"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/pro.3943","type":"journal-article","article-title":"UCSF ChimeraX: Structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Science"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1085\/jgp.201812121","type":"journal-article","article-title":"The S6 gate in regulatory Kv6 subunits restricts heteromeric K+ channel stoichiometry","volume":"150","author":"Pisupati","year":"2018","journal-title":"Journal of General Physiology"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1085\/jgp.201110604","type":"journal-article","article-title":"SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons","volume":"137","author":"Plant","year":"2011","journal-title":"The Journal of General Physiology"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/s0014-5793(96)01316-6","type":"journal-article","article-title":"Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current","volume":"399","author":"Post","year":"1996","journal-title":"FEBS Letters"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1097\/j.pain.0000000000001217","type":"journal-article","article-title":"Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq-based resource for pain and sensory neuroscience research","volume":"159","author":"Ray","year":"2018","journal-title":"Pain"},{"key":"bib68","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12731","type":"journal-article","article-title":"The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons","volume":"4","author":"Regnier","year":"2016","journal-title":"Physiological Reports"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1071\/RD16075","type":"journal-article","article-title":"Targeted deletion of the Kv6.4 subunit causes male sterility due to disturbed spermiogenesis","volume":"29","author":"Regnier","year":"2017","journal-title":"Reproduction, Fertility, and Development"},{"key":"bib70","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05312-1","type":"journal-article","article-title":"A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels","volume":"81","author":"Renigunta","year":"2024","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/s0378-5955(00)00117-9","type":"journal-article","article-title":"Modification of delayed rectifier potassium currents by the Kv9.1 potassium channel subunit","volume":"147","author":"Richardson","year":"2000","journal-title":"Hearing Research"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"8774","DOI":"10.1074\/jbc.272.13.8774","type":"journal-article","article-title":"Modes of regulation of shaion of Shab K+ channel activity by the Kv8.1 Subunit","volume":"272","author":"Salinas","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"24371","DOI":"10.1074\/jbc.272.39.24371","type":"journal-article","article-title":"New modulatory alpha subunits for mammalian Shab K+ channels","volume":"272","author":"Salinas","year":"1997","journal-title":"The Journal of Biological Chemistry"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/wcms.1121","type":"journal-article","article-title":"An overview of the Amber biomolecular simulation package","volume":"3","author":"Salomon\u2010Ferrer","year":"2013","journal-title":"WIREs Computational Molecular Science"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/s0014-5793(02)02267-6","type":"journal-article","article-title":"Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1","volume":"512","author":"Sano","year":"2002","journal-title":"FEBS Letters"},{"key":"bib76","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.615362","type":"journal-article","article-title":"Comparative analysis of dorsal root, nodose and sympathetic ganglia for the development of new analgesics","volume":"14","author":"Sapio","year":"2020","journal-title":"Frontiers in Neuroscience"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1016\/j.bpj.2022.03.020","type":"journal-article","article-title":"The AMIGO1 adhesion protein activates Kv2.1 voltage sensors","volume":"121","author":"Sepela","year":"2022","journal-title":"Biophysical Journal"},{"key":"bib78","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202413740","type":"journal-article","article-title":"Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels","volume":"157","author":"Simonson","year":"2025","journal-title":"The Journal of General Physiology"},{"key":"bib79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141349","type":"journal-article","article-title":"Modulation of closed-state inactivation in kv2.1\/kv6.4 heterotetramers as mechanism for 4-ap induced potentiation","volume":"10","author":"Stas","year":"2015","journal-title":"PLOS ONE"},{"key":"bib80","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25575","type":"journal-article","article-title":"Distinct cellular expression and subcellular localization of Kv2 voltage-gated K+ channel subtypes in dorsal root ganglion neurons conserved between mice and humans","volume":"532","author":"Stewart","year":"2024","journal-title":"The Journal of Comparative Neurology"},{"key":"bib81","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202012858","type":"journal-article","article-title":"EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues","volume":"153","author":"Thapa","year":"2021","journal-title":"The Journal of General Physiology"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1113\/jphysiol.2003.039859","type":"journal-article","article-title":"Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current","volume":"549","author":"Thorneloe","year":"2003","journal-title":"The Journal of Physiology"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"E4789","DOI":"10.1073\/pnas.1406876111","type":"journal-article","article-title":"Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells","volume":"111","author":"Tilley","year":"2014","journal-title":"PNAS"},{"key":"bib84","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1085\/jgp.201812213","type":"journal-article","article-title":"The tarantula toxin GxTx detains K","volume":"151","author":"Tilley","year":"2019","journal-title":"The Journal of General Physiology"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1073\/pnas.94.4.1527","type":"journal-article","article-title":"Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons","volume":"94","author":"Toledo-Aral","year":"1997","journal-title":"PNAS"},{"key":"bib86","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-4-15","type":"journal-article","article-title":"Control of ion channel expression for patch clamp recordings using an inducible expression system in mammalian cell lines","volume":"4","author":"Trapani","year":"2003","journal-title":"BMC Neuroscience"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0014-5793(93)81394-f","type":"journal-article","article-title":"Expression of Kv2.1 delayed rectifier K+ channel isoforms in the developing rat brain","volume":"324","author":"Trimmer","year":"1993","journal-title":"FEBS Letters"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"17502","DOI":"10.1523\/JNEUROSCI.3561-12.2012","type":"journal-article","article-title":"Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury","volume":"32","author":"Tsantoulas","year":"2012","journal-title":"The Journal of Neuroscience"},{"key":"bib89","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1097\/j.pain.0000000000001255","type":"journal-article","article-title":"Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity","volume":"159","author":"Tsantoulas","year":"2018","journal-title":"Pain"},{"key":"bib90","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jmb.2010.11.008","type":"journal-article","article-title":"Alternate states of proteins revealed by detailed energy landscape mapping","volume":"405","author":"Tyka","year":"2011","journal-title":"Journal of Molecular Biology"},{"key":"bib91","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1038\/nprot.2016.111","type":"journal-article","article-title":"Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures","volume":"11","author":"Valtcheva","year":"2016","journal-title":"Nature Protocols"},{"key":"bib92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2110094118","type":"journal-article","article-title":"Regulation of neuronal excitation-transcription coupling by Kv2.1-induced clustering of somatic L-type Ca2+ channels at ER-PM junctions","volume":"118","author":"Vierra","year":"2021","journal-title":"PNAS"},{"key":"bib93","doi-asserted-by":"publisher","first-page":"18102","DOI":"10.1073\/pnas.1206952109","type":"journal-article","article-title":"Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected]","volume":"109","author":"Walker","year":"2012","journal-title":"PNAS"},{"key":"bib94","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.17219","type":"journal-article","article-title":"Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta","volume":"5","author":"Wang","year":"2016","journal-title":"eLife"},{"key":"bib95","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1086\/507568","type":"journal-article","article-title":"Mutations in the gene KCNV2 encoding a voltage-gated potassium channel subunit cause \u201ccone dystrophy with supernormal rod electroretinogram\u201d in humans","volume":"79","author":"Wu","year":"2006","journal-title":"American Journal of Human Genetics"},{"key":"bib96","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.101855.1","type":"journal-article","article-title":"Distinct Mechanisms of Inhibition of Kv2 Potassium Channels by Tetraethylammonium and RY785","volume":"13","author":"Zhang","year":"2024","journal-title":"eLife"},{"key":"bib97","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.neuron.2019.05.039","type":"journal-article","article-title":"Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties","volume":"103","author":"Zheng","year":"2019","journal-title":"Neuron"},{"key":"bib98","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1113\/jphysiol.2010.196618","type":"journal-article","article-title":"Stromatoxin-sensitive, heteromultimeric Kv2.1\/Kv9.3 channels contribute to myogenic control of cerebral arterial diameter","volume":"588","author":"Zhong","year":"2010","journal-title":"The Journal of Physiology"},{"key":"bib99","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuron.2004.12.015","type":"journal-article","article-title":"Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd","volume":"45","author":"Zylka","year":"2005","journal-title":"Neuron"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/99410\/elife-99410-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/99410\/elife-99410-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/99410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:37:04Z","timestamp":1787564224000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/99410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":99,"alternative-id":["10.7554\/eLife.99410"],"URL":"https:\/\/doi.org\/10.7554\/elife.99410","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.01.31.578214","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2024.01.31.578214","asserted-by":"object"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.99410.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.99410.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.99410.2","asserted-by":"subject"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,27]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP99410"}}