{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:59:03Z","timestamp":1774353543958,"version":"3.50.1"},"reference-count":40,"publisher":"Journal of Biomedical Research","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Res"],"published-print":{"date-parts":[[2026]]},"DOI":"10.7555\/jbr.39.20250250","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T02:43:43Z","timestamp":1752720223000},"page":"196","source":"Crossref","is-referenced-by-count":2,"title":["Heterogeneity of lymphoid cells in PBMCs in the acute phase of SFTS: Single-cell transcriptome profiling"],"prefix":"10.7555","volume":"40","author":[{"given":"Jiaying","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruowei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dafeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaojiao","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4380","reference":[{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.1","doi-asserted-by":"publisher","unstructured":"Li H, Zhang L, Li S, et al. Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality[J]. <i>Cell Res<\/i>, 2019, 29(9): 739\u2013753.","DOI":"10.1038\/s41422-019-0214-z"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.2","doi-asserted-by":"publisher","unstructured":"Yang T, Huang H, Jiang L, et al. Overview of the immunological mechanism underlying severe fever with thrombocytopenia syndrome (Review)[J]. <i>Int J Mol Med<\/i>, 2022, 50(3): 118.","DOI":"10.3892\/ijmm.2022.5174"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.3","doi-asserted-by":"publisher","unstructured":"Chinese Society of Infectious Diseases, Chinese Medical Association. Consensus on the diagnosis and treatment of severe fever with thrombocytopenia syndrome[J]. <i>Chin J Infect Dis<\/i>, 2022, 40(12): 711\u2013721.","DOI":"10.3760\/cma.j.cn311365-20221017-00425"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.4","doi-asserted-by":"publisher","unstructured":"Yuan Y, Cui N, Yuan C. Recommendations for nomenclature, clinical staging and typing of severe fever with thrombocytopenia syndrome[J]. <i>Chin J Infect Dis<\/i>, 2016, 34(1): 57\u201358.","DOI":"10.3760\/cma.j.issn.1000-6680.2016.01.016"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.5","doi-asserted-by":"publisher","unstructured":"Wei Y, Wang Z, Kang L, et al. NLR, A convenient early-warning biomarker of fatal outcome in patients with severe fever with thrombocytopenia syndrome[J]. <i>Front Microbiol<\/i>, 2022, 13: 907888.","DOI":"10.3389\/fmicb.2022.907888"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.6","doi-asserted-by":"publisher","unstructured":"Wang L, Wan G, Shen Y, et al. A nomogram to predict mortality in patients with severe fever with thrombocytopenia syndrome at the early stage-a multicenter study in China[J]. <i>PLoS Negl Trop Dis<\/i>, 2019, 13(11): e0007829.","DOI":"10.1371\/journal.pntd.0007829"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.7","doi-asserted-by":"publisher","unstructured":"Wang M, Huang P, Liu W, et al. Risk factors of severe fever with thrombocytopenia syndrome combined with central neurological complications: A five-year retrospective case-control study[J]. <i>Front Microbiol<\/i>, 2022, 13: 1033946.","DOI":"10.3389\/fmicb.2022.1033946"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.8","doi-asserted-by":"publisher","unstructured":"Xu Y, Shao M, Liu N, et al. Clinical feature of severe fever with thrombocytopenia syndrome (SFTS)-associated encephalitis\/encephalopathy: A retrospective study[J]. <i>BMC Infect Dis<\/i>, 2021, 21(1): 904.","DOI":"10.1186\/s12879-021-06627-1"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.9","doi-asserted-by":"publisher","unstructured":"Casel MA, Park SJ, Choi YK. Severe fever with thrombocytopenia syndrome virus: Emerging novel phlebovirus and their control strategy[J]. <i>Exp Mol Med<\/i>, 2021, 53(5): 713\u2013722.","DOI":"10.1038\/s12276-021-00610-1"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.10","doi-asserted-by":"publisher","unstructured":"Li M, Zhang W, Weng X, et al. CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)[J]. <i>Clin Immunol<\/i>, 2018, 195: 8\u201317.","DOI":"10.1016\/j.clim.2018.07.009"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.11","doi-asserted-by":"publisher","unstructured":"Li M, Zhang W, Liu J, et al. Dynamic changes in the immunological characteristics of T lymphocytes in surviving patients with severe fever with thrombocytopenia syndrome (SFTS)[J]. <i>Int J Infect Dis<\/i>, 2018, 70: 72\u201380.","DOI":"10.1016\/j.ijid.2018.03.010"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.12","doi-asserted-by":"publisher","unstructured":"Song P, Zheng N, Liu Y, et al. Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection[J]. <i>Nat Commun<\/i>, 2018, 9(1): 3328.","DOI":"10.1038\/s41467-018-05746-9"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.13","doi-asserted-by":"publisher","unstructured":"Kang SY, Yoo JR, Park Y, et al. Fatal outcome of severe fever with thrombocytopenia syndrome (SFTS) and severe and critical COVID-19 is associated with the hyperproduction of IL-10 and IL-6 and the low production of TGF-\u03b2[J]. <i>J Med Virol<\/i>, 2023, 95(7): e28894.","DOI":"10.1002\/jmv.28894"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.14","doi-asserted-by":"publisher","unstructured":"Wu F, Fan J, He Y, et al. Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer[J]. <i>Nat Commun<\/i>, 2021, 12(1): 2540.","DOI":"10.1038\/s41467-021-22801-0"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.15","doi-asserted-by":"publisher","unstructured":"Morabito S, Reese F, Rahimzadeh N, et al. hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data[J]. <i>Cell Rep Methods<\/i>, 2023, 3(6): 100498.","DOI":"10.1016\/j.crmeth.2023.100498"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.16","doi-asserted-by":"publisher","unstructured":"Zhang Y, Liu T, Hu X, et al. CellCall: Integrating paired ligand-receptor and transcription factor activities for cell-cell communication[J]. <i>Nucleic Acids Res<\/i>, 2021, 49(15): 8520\u20138534.","DOI":"10.1093\/nar\/gkab638"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.17","doi-asserted-by":"publisher","unstructured":"Zhou X, Yu S, Zhao DM, et al. Differentiation and persistence of memory CD8<sup>+<\/sup> T cells depend on T cell factor 1[J]. <i>Immunity<\/i>, 2010, 33(2): 229\u2013240.","DOI":"10.1016\/j.immuni.2010.08.002"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.18","doi-asserted-by":"publisher","unstructured":"Cerutti A, Cols M, Puga I. Marginal zone B cells: Virtues of innate-like antibody-producing lymphocytes[J]. <i>Nat Rev Immunol<\/i>, 2013, 13(2): 118\u2013132.","DOI":"10.1038\/nri3383"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.19","doi-asserted-by":"publisher","unstructured":"Liu S, Cao Y, Cui K, et al. Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction[J]. <i>Immunity<\/i>, 2024, 57(5): 987\u20131004.e5.","DOI":"10.1016\/j.immuni.2024.03.018"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.20","doi-asserted-by":"publisher","unstructured":"Loo CS, Gatchalian J, Liang Y, et al. A genome-wide CRISPR screen reveals a role for the non-canonical nucleosome-remodeling BAF complex in foxp3 expression and regulatory T cell function[J]. <i>Immunity<\/i>, 2020, 53(1): 143\u2013157.e8.","DOI":"10.1016\/j.immuni.2020.06.011"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.21","doi-asserted-by":"publisher","unstructured":"Kim S, Kim Y, Kim Y, et al. PCNA Ser46-Leu47 residues are crucial in preserving genomic integrity[J]. <i>PLoS One<\/i>, 2023, 18(5): e0285337.","DOI":"10.1371\/journal.pone.0285337"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.22","doi-asserted-by":"publisher","unstructured":"Yin DM, Yuan D, Sun RJ, et al. Identification of ORM1, vWF, SPARC, and PPBP as immune-related proteins involved in immune thrombocytopenia by quantitative LC-MS\/MS[J]. <i>Clin Proteomics<\/i>, 2023, 20(1): 24.","DOI":"10.1186\/s12014-023-09413-0"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.23","doi-asserted-by":"publisher","unstructured":"Li M, Xiong Y, Li M, et al. Depletion but activation of CD56<sup>dim<\/sup>CD16<sup>+<\/sup> NK cells in acute infection with severe fever with thrombocytopenia syndrome virus[J]. <i>Virol Sin<\/i>, 2020, 35(5): 588\u2013598.","DOI":"10.1007\/s12250-020-00224-3"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.24","doi-asserted-by":"publisher","unstructured":"Letafati A, Ardekani OS, Naderisemiromi M, et al. Unraveling the dynamic mechanisms of natural killer cells in viral infections: Insights and implications[J]. <i>Virol J<\/i>, 2024, 21(1): 18.","DOI":"10.1186\/s12985-024-02287-0"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.25","doi-asserted-by":"publisher","unstructured":"Huisman BD, Guan N, R\u00fcckert T, et al. High-throughput characterization of HLA-E-presented CD94\/NKG2x ligands reveals peptides which modulate NK cell activation[J]. <i>Nat Commun<\/i>, 2023, 14(1): 4809.","DOI":"10.1038\/s41467-023-40220-1"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.26","doi-asserted-by":"publisher","unstructured":"Blakemore D, Vilaplana-Lopera N, Almaghrabi R, et al. MYBL2 and ATM suppress replication stress in pluripotent stem cells[J]. <i>EMBO Rep<\/i>, 2021, 22(5): e51120.","DOI":"10.15252\/embr.202051120"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.27","doi-asserted-by":"publisher","unstructured":"Mebratu YA, Imani J, Jones JT, et al. Casein kinase \u2161 activates Bik to induce death of hyperplastic mucous cells in a cell cycle-dependent manner[J]. <i>J Cell Physiol<\/i>, 2022, 237(2): 1561\u20131572.","DOI":"10.1002\/jcp.30630"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.28","doi-asserted-by":"publisher","unstructured":"Yu B, Qi Y, Li R, et al. B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells[J]. <i>Cell<\/i>, 2021, 184(7): 1790\u20131803.e17.","DOI":"10.1016\/j.cell.2021.02.015"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.29","doi-asserted-by":"publisher","unstructured":"Zhou S, Ouyang W, Zhang X, et al. UTRN inhibits melanoma growth by suppressing p38 and JNK\/c-Jun signaling pathways[J]. <i>Cancer Cell Int<\/i>, 2021, 21(1): 88.","DOI":"10.1186\/s12935-021-01768-4"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.30","doi-asserted-by":"publisher","unstructured":"Liu B, Zhang Y, Ren H, et al. mTOR signaling regulates Zika virus replication bidirectionally through autophagy and protein translation[J]. <i>J Med Virol<\/i>, 2023, 95(1): e28422.","DOI":"10.1002\/jmv.28422"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.31","doi-asserted-by":"publisher","unstructured":"Wang J, Li H, Xue B, et al. IRF1 promotes the innate immune response to viral infection by enhancing the activation of IRF3[J]. <i>J Virol<\/i>, 2020, 94(22): e01231\u201320.","DOI":"10.1128\/JVI.01231-20"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.32","doi-asserted-by":"publisher","unstructured":"Mathew NR, Jayanthan JK, Smirnov IV, et al. Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells[J]. <i>Cell Rep<\/i>, 2021, 35(12): 109286.","DOI":"10.1016\/j.celrep.2021.109286"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.33","doi-asserted-by":"publisher","unstructured":"Friedrich T, Ferrante F, Pioger L, et al. Notch-dependent and -independent functions of transcription factor RBPJ[J]. <i>Nucleic Acids Res<\/i>, 2022, 50(14): 7925\u20137937.","DOI":"10.1093\/nar\/gkac601"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.34","doi-asserted-by":"publisher","unstructured":"See YX, Chen K, Fullwood MJ. <i>MYC<\/i> overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sites[J]. <i>Genome Res<\/i>, 2022, 32(4): 629\u2013642.","DOI":"10.1101\/gr.276313.121"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.35","doi-asserted-by":"publisher","unstructured":"Ottens K, Satterthwaite AB. IRF4 has a unique role in early B cell development and acts prior to CD21 expression to control marginal zone B cell numbers[J]. <i>Front Immunol<\/i>, 2021, 12: 779085.","DOI":"10.3389\/fimmu.2021.779085"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.36","doi-asserted-by":"publisher","unstructured":"Kohata M, Imai J, Izumi T, et al. Roles of FoxM1-driven basal \u03b2-cell proliferation in maintenance of \u03b2-cell mass and glucose tolerance during adulthood[J]. <i>J Diabetes Investig<\/i>, 2022, 13(10): 1666\u20131676.","DOI":"10.1111\/jdi.13846"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.37","doi-asserted-by":"publisher","unstructured":"Zhou W, Gao F, Romero-Wolf M, et al. Single-cell deletion analyses show control of pro-T cell developmental speed and pathways by Tcf7, Spi1, Gata3, Bcl11a, Erg, and Bcl11b[J]. <i>Sci Immunol<\/i>, 2022, 7(71): eabm1920.","DOI":"10.1126\/sciimmunol.abm1920"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.38","doi-asserted-by":"publisher","unstructured":"Lundell LS, Massart J, Alt\u0131nta\u015f A, et al. Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle[J]. <i>Mol Metab<\/i>, 2019, 20: 79\u201388.","DOI":"10.1016\/j.molmet.2018.09.011"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.39","doi-asserted-by":"publisher","unstructured":"Zhang J, Wang X, Xing X, et al. Single-cell landscape of immunological responses in patients with COVID-19[J]. <i>Nat Immunol<\/i>, 2020, 21(9): 1107\u20131118.","DOI":"10.1038\/s41590-020-0762-x"},{"key":"10.7555\/JBR.39.20250250.swyxyjzzywb.40","doi-asserted-by":"publisher","unstructured":"Park A, Park SJ, Jung KL, et al. Molecular signatures of inflammatory profile and B-cell function in patients with severe fever with thrombocytopenia syndrome[J]. <i>mBio<\/i>, 2021, 12(1): e02583\u201320.","DOI":"10.1128\/mBio.02583-20"}],"container-title":["Journal of Biomedical Research"],"original-title":[],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T10:20:11Z","timestamp":1774347611000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jbr-pub.org.cn\/article\/doi\/10.7555\/JBR.39.20250250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"alternative-id":["JBR-2025-0250"],"URL":"https:\/\/doi.org\/10.7555\/jbr.39.20250250","relation":{},"ISSN":["1674-8301","1674-8301"],"issn-type":[{"value":"1674-8301","type":"print"},{"value":"1674-8301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}