{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:45:11Z","timestamp":1790718311887,"version":"4.1.0"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p id=\"P3_w2aab3b7c49b1b6b1aab1c16b1Aa\">Ionizing radiation exposure can induce profound changes in intracellular components, potentially leading to diverse health effects in exposed individuals. Any cellular component can be damaged by radiation, but some components affect cellular viability more profoundly than others. The ionization caused by radiation lasts longer than the initial inciting incident, continuing as 1 ionization incident causes another. In some cases, damage to DNA can lead to cellular death at mitosis. In other cases, activation of the genetic machinery can lead to a genetic cascade potentially leading to mutations or cell death by apoptosis. In the third of 5 articles on the management of injuries and illnesses caused by ionizing radiation, the authors provide a clinically relevant overview of the pathophysiologic process associated with potential exposure to ionizing radiation.<\/jats:p>","DOI":"10.7556\/jaoa.2014.109","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T14:43:51Z","timestamp":1403880231000},"page":"556-565","source":"Crossref","is-referenced-by-count":13,"title":["Management of Ionizing Radiation Injuries and Illnesses, Part 3: Radiobiology and Health Effects of Ionizing Radiation"],"prefix":"10.1515","volume":"114","author":[{"given":"Doran M.","family":"Christensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon K.","family":"Livingston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Sugarman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Parillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik S.","family":"Glassman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,7,1]]},"reference":[{"issue":"5","key":"2021040110323366808_j_jaoa.2014.109_ref_001_w2aab3b7c49b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","first-page":"383","DOI":"10.7556\/jaoa.2014.075","article-title":"Management of ionizing radiation injuries and illnesses, part 2: nontherapeutic radiologic\/nuclear incidents","volume":"114","author":"Christensen","year":"2014","journal-title":"J Am Osteopath Assoc."},{"key":"2021040110323366808_j_jaoa.2014.109_ref_002_w2aab3b7c49b1b6b1ab2b1b2Aa","volume-title":"Radiobiology for the Radiologist","author":"Hall","year":"2012","edition":"7th ed."},{"key":"2021040110323366808_j_jaoa.2014.109_ref_003_w2aab3b7c49b1b6b1ab2b1b3Aa","volume-title":"Basic Radiation Protection Technology","author":"Gollnick","year":"2006","edition":"5th ed."},{"key":"2021040110323366808_j_jaoa.2014.109_ref_004_w2aab3b7c49b1b6b1ab2b1b4Aa","volume-title":"Management of Persons Contaminated With Radionuclides: Handbook","year":"2010"},{"key":"2021040110323366808_j_jaoa.2014.109_ref_005_w2aab3b7c49b1b6b1ab2b1b5Aa","first-page":"983","article-title":"De quelques r\u00e9sultats de la radiotherapie et essai de fixation d'une technique rationnelle","volume":"143","author":"Bergoni\u00e9","year":"1906","journal-title":"Comptes-Rendus des S\u00e9ances de l'Acad\u00e9mie des Sciences"},{"key":"2021040110323366808_j_jaoa.2014.109_ref_006_w2aab3b7c49b1b6b1ab2b1b6Aa","volume-title":"Medical Effects of Ionizing Radiation","author":"Metter","year":"2009","edition":"3rd ed."},{"issue":"3","key":"2021040110323366808_j_jaoa.2014.109_ref_007_w2aab3b7c49b1b6b1ab2b1b7Aa","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1148\/radiol.09090330","article-title":"Medical response to a major radiologic emergency: a primer for medical and public health practitioners","volume":"254","author":"Wolbarst","year":"2010","journal-title":"Radiology"},{"key":"2021040110323366808_j_jaoa.2014.109_ref_008_w2aab3b7c49b1b6b1ab2b1b8Aa","volume-title":"Radiobiology for the Radiologist","author":"Hall","year":"2006","edition":"6th ed."},{"key":"2021040110323366808_j_jaoa.2014.109_ref_009_w2aab3b7c49b1b6b1ab2b1b9Aa","article-title":"Management of ionizing radiation injuries and illnesses, part 5: radiation-related diseases\u2014acute radiation syndrome","volume-title":"J Am Osteopath Assoc.","author":"Christensen"},{"key":"2021040110323366808_j_jaoa.2014.109_ref_010_w2aab3b7c49b1b6b1ab2b1c10Aa","article-title":"Medical management during the prodromal and latent periods","volume-title":"The Medical Basis for Radiation-Accident Preparedness: The Clinical Care of Victims","author":"Cosset","year":"2002"},{"key":"2021040110323366808_j_jaoa.2014.109_ref_011_w2aab3b7c49b1b6b1ab2b1c11Aa","article-title":"Clinical care of the radiation-accident patient: patient presentation, assessment, and initial diagnosis","volume-title":"The Medical Basis for Radiation-Accident Preparedness: The Clinical Care of Victims","author":"Goans","year":"2002"},{"key":"2021040110323366808_j_jaoa.2014.109_ref_012_w2aab3b7c49b1b6b1ab2b1c12Aa","unstructured":"About lymphocyte depletion kinetics. 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