{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T01:54:42Z","timestamp":1784339682202,"version":"3.55.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"Abstract<\/jats:title>\n \n Context:<\/jats:bold> Osteopathic manipulative therapy (OMTh; manipulative care provided by foreign-trained osteopaths) may be used for managing headache pain and related disability, but there is a need for high-quality randomized controlled trials to assess the effectiveness of this intervention.<\/jats:p>\n \n Objective:<\/jats:bold> To explore the efficacy of OMTh for pain management in frequent episodic tension-type headache (TTH).<\/jats:p>\n \n Design:<\/jats:bold> Single-blind randomized placebo-controlled pilot study.<\/jats:p>\n \n Setting:<\/jats:bold> Patients were recruited from 5 primary care settings.<\/jats:p>\n \n Patients:<\/jats:bold> Forty-four patients who were affected by frequent episodic TTH and not taking any drugs for prophylactic management of episodic TTH were recruited.<\/jats:p>\n \n Interventions:<\/jats:bold> Patients were randomly allocated to an experimental or control group. The experimental group received corrective OMTh techniques, tailored for each patient; the control group received assessment of the cranial rhythmic impulse (sham therapy). The study included a 1-month baseline period, a 1-month treatment period, and a 3-month follow-up period.<\/jats:p>\n \n Main Outcome Measures:<\/jats:bold> The primary outcome was the change in patient-reported headache frequency, and secondary outcomes included changes in headache pain intensity (discrete score, 1 [lowest perceived pain] to 5 [worst perceived pain]), over-the-counter medication use, and Headache Disability Inventory score.<\/jats:p>\n \n Results:<\/jats:bold> Forty patients completed the study (OMTh, n=21; control, n=19). The OMTh group had a significant reduction in headache frequency over time that persisted 1 month (approximate reduction, 40%; P<\/jats:italic><.001) and 3 months (approximate reduction, 50%; P<\/jats:italic><.001) after the end of treatment. Moreover, there was an absolute difference between the 2 treatment groups at the end of the study, with a 33% lower frequency of headache in the OMTh group (P<\/jats:italic><.001).<\/jats:p>\n \n Conclusion:<\/jats:bold> This feasibility study demonstrated the efficacy of OMTh in the management of frequent episodic TTH, compared with sham therapy in a control group. Osteopathic manipulative therapy may be preferred over other treatment modalities and may benefit patients who have adverse effects to medications or who have difficulty complying with pharmacologic regimens. This protocol may serve as a model for future studies.<\/jats:p>","DOI":"10.7556\/jaoa.2014.136","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T14:16:40Z","timestamp":1408457800000},"page":"678-685","source":"Crossref","is-referenced-by-count":31,"title":["Pilot Trial of Osteopathic Manipulative Therapy for Patients With Frequent Episodic Tension-Type Headache"],"prefix":"10.1515","volume":"114","author":[{"given":"Guido","family":"Rolle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Tremolizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Somalvico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Ferrarese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio C.","family":"Bressan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,9,1]]},"reference":[{"issue":"11","key":"2021040110352623899_j_jaoa.2014.136_ref_001_w2aab3b7c24b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0895-4356(91)90147-2","article-title":"Epidemiology of headache in a general population\u2014a prevalence study","volume":"44","author":"Rasmussen","year":"1991","journal-title":"J Clin Epidemiol."},{"issue":"5","key":"2021040110352623899_j_jaoa.2014.136_ref_002_w2aab3b7c24b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1001\/jama.279.5.381","article-title":"Epidemiology of tension-type headache","volume":"279","author":"Schwartz","year":"1998","journal-title":"JAMA"},{"issue":"4","key":"2021040110352623899_j_jaoa.2014.136_ref_003_w2aab3b7c24b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S1474-4422(08)70062-0","article-title":"Epidemiology and comorbidity of headache","volume":"7","author":"Jensen","year":"2008","journal-title":"Lancet Neurol."},{"issue":"7","key":"2021040110352623899_j_jaoa.2014.136_ref_004_w2aab3b7c24b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1517\/14656566.2011.548806","article-title":"Treating tension-type headache\u2014an expert opinion","volume":"12","author":"Bendtsen","year":"2011","journal-title":"Expert Opin Pharmacother."},{"issue":"3","key":"2021040110352623899_j_jaoa.2014.136_ref_005_w2aab3b7c24b1b6b1ab2b1b5Aa","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/01.ajp.0000173017.64741.86","article-title":"Are manual therapies effective in reducing pain from tension-type headache? a systematic review","volume":"22","author":"Fern\u00e1ndez-de-Las-Pe\u00f1as","year":"2006","journal-title":"Clin J Pain"},{"issue":"3","key":"2021040110352623899_j_jaoa.2014.136_ref_006_w2aab3b7c24b1b6b1ab2b1b6Aa","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2519\/jospt.2006.36.3.160","article-title":"Methodological quality of randomized controlled trials of spinal manipulation and mobilization in tension-type headache, migraine, and cervicogenic headache","volume":"36","author":"Fern\u00e1ndez-de-Las-Pe\u00f1as","year":"2006","journal-title":"J Orthop Sports Phys Ther."},{"issue":"2","key":"2021040110352623899_j_jaoa.2014.136_ref_007_w2aab3b7c24b1b6b1ab2b1b7Aa","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/ecam\/nel109","article-title":"Effectiveness of massage therapy for chronic, non-malignant pain: a review","volume":"4","author":"Tsao","year":"2007","journal-title":"Evid Based Complement Alternat Med."},{"issue":"3","key":"2021040110352623899_j_jaoa.2014.136_ref_008_w2aab3b7c24b1b6b1ab2b1b8Aa","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.pain.2004.09.026","article-title":"The effectiveness of physiotherapy and manipulation in patients with tension-type headache: a systematic review","volume":"112","author":"Lenssinck","year":"2004","journal-title":"Pain"},{"issue":"8","key":"2021040110352623899_j_jaoa.2014.136_ref_009_w2aab3b7c24b1b6b1ab2b1b9Aa","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1468-2982.2002.00423.x","article-title":"The effectiveness of spinal manipulation for the treatment of headache disorders: a systematic review of randomized clinical trials","volume":"22","author":"Astin","year":"2002","journal-title":"Cephalalgia"},{"key":"2021040110352623899_j_jaoa.2014.136_ref_010_w2aab3b7c24b1b6b1ab2b1c10Aa","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1097\/00007632-200209010-00004","article-title":"A randomized controlled trial of exercise and manipulative therapy for cervicogenic headache","volume":"27","author":"Jull","year":"2002","journal-title":"Spine (Phila Pa 1976)"},{"issue":"7","key":"2021040110352623899_j_jaoa.2014.136_ref_011_w2aab3b7c24b1b6b1ab2b1c11Aa","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0161-4754(01)99423-0","article-title":"Efficacy of spinal manipulation for chronic headache: a systematic review","volume":"24","author":"Bronfort","year":"2001","journal-title":"J Manipulative Physiol Ther."},{"issue":"4","key":"2021040110352623899_j_jaoa.2014.136_ref_012_w2aab3b7c24b1b6b1ab2b1c12Aa","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ctim.2011.12.001","article-title":"Spinal manipulations for tension-type headaches: a systematic review of randomized controlled trials","volume":"20","author":"Posadzki","year":"2012","journal-title":"Complement Ther Med."},{"issue":"5","key":"2021040110352623899_j_jaoa.2014.136_ref_013_w2aab3b7c24b1b6b1ab2b1c13Aa","first-page":"322","article-title":"Osteopathic manipulation in the treatment of muscle-contraction headache","volume":"78","author":"Hoyt","year":"1979","journal-title":"J Am Osteopath Assoc."},{"issue":"4","key":"2021040110352623899_j_jaoa.2014.136_ref_014_w2aab3b7c24b1b6b1ab2b1c14Aa","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jbmt.2011.01.021","article-title":"Effectiveness of direct vs indirect technique myofascial release in the management of tension-type headache","volume":"15","author":"Ajimsha","year":"2011","journal-title":"J Bodyw Mov Ther."},{"issue":"3","key":"2021040110352623899_j_jaoa.2014.136_ref_015_w2aab3b7c24b1b6b1ab2b1c15Aa","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1089\/acm.2009.0673","article-title":"Efficacy of osteopathic manipulative treatment of female patients with migraine: results of a randomized controlled trial","volume":"17","author":"Voigt","year":"2011","journal-title":"J Altern Complement Med."},{"issue":"8","key":"2021040110352623899_j_jaoa.2014.136_ref_016_w2aab3b7c24b1b6b1ab2b1c16Aa","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1526-4610.2006.00535.x","article-title":"A comparison of selected osteopathic treatment and relaxation for tension-type headaches","volume":"46","author":"Anderson","year":"2006","journal-title":"Headache"},{"issue":"3","key":"2021040110352623899_j_jaoa.2014.136_ref_017_w2aab3b7c24b1b6b1ab2b1c17Aa","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001878.pub2","article-title":"Non-invasive physical treatments for chronic\/recurrent headache","author":"Bronfort","year":"2004","journal-title":"Cochrane Database Syst Rev."},{"issue":"6","key":"2021040110352623899_j_jaoa.2014.136_ref_018_w2aab3b7c24b1b6b1ab2b1c18Aa","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s11916-006-0078-z","article-title":"Burden of tension-type headache","volume":"10","author":"Lenaerts","year":"2006","journal-title":"Curr Pain Headache Rep."},{"issue":"3","key":"2021040110352623899_j_jaoa.2014.136_ref_019_w2aab3b7c24b1b6b1ab2b1c19Aa","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1468-2982.2007.01288.x","article-title":"The global burden of headache: a documentation of headache prevalence and disability worldwide","volume":"27","author":"Stovner","year":"2007","journal-title":"Cephalalgia"},{"issue":"1","key":"2021040110352623899_j_jaoa.2014.136_ref_020_w2aab3b7c24b1b6b1ab2b1c20Aa","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1468-2982.2009.01948.x","article-title":"Guidelines for controlled trials of drugs in tension-type headache: second edition","volume":"30","author":"Bendtsen","year":"2010","journal-title":"Cephalalgia"},{"issue":"9","key":"2021040110352623899_j_jaoa.2014.136_ref_021_w2aab3b7c24b1b6b1ab2b1c21Aa","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1177\/0333102413485658","article-title":"The International Classification of Headache Disorders, 3rd edition (beta version)","volume":"33","year":"2013","journal-title":"Cephalalgia"},{"issue":"8","key":"2021040110352623899_j_jaoa.2014.136_ref_022_w2aab3b7c24b1b6b1ab2b1c22Aa","first-page":"457","article-title":"Blinding protocols, treatment credibility, and expectancy: methodologic issues in clinical trials of osteopathic manipulative treatment","volume":"106","author":"Licciardone","year":"2006","journal-title":"J Am Osteopath Assoc."},{"key":"2021040110352623899_j_jaoa.2014.136_ref_023_w2aab3b7c24b1b6b1ab2b1c23Aa","volume-title":"Principles of Manual Medicine","author":"Greenman","year":"2003","edition":"3rd ed."},{"issue":"5","key":"2021040110352623899_j_jaoa.2014.136_ref_024_w2aab3b7c24b1b6b1ab2b1c24Aa","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1212\/WNL.44.5.837","article-title":"The Henry Ford Hospital Headache Disability Inventory (HDI)","volume":"44","author":"Jacobson","year":"1994","journal-title":"Neurology"},{"issue":"4","key":"2021040110352623899_j_jaoa.2014.136_ref_025_w2aab3b7c24b1b6b1ab2b1c25Aa","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.math.2012.02.011","article-title":"What puts the adverse in \u2018adverse events\u2019? patients' perceptions of post-treatment experiences in osteopathy\u2014a qualitative study using focus groups","volume":"17","author":"Rajendran","year":"2012","journal-title":"Man Ther."},{"issue":"9","key":"2021040110352623899_j_jaoa.2014.136_ref_026_w2aab3b7c24b1b6b1ab2b1c26Aa","first-page":"387","article-title":"Role of osteopathic manipulative treatment in altering pain biomarkers: a pilot study","volume":"107","author":"Degenhardt","year":"2007","journal-title":"J Am Osteopath Assoc."}],"container-title":["Journal of Osteopathic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.7556\/jaoa.2014.136\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.7556\/jaoa.2014.136\/html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T11:00:13Z","timestamp":1617274813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.7556\/jaoa.2014.136\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,1]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,1]]},"published-print":{"date-parts":[[2014,9,1]]}},"alternative-id":["10.7556\/jaoa.2014.136"],"URL":"https:\/\/doi.org\/10.7556\/jaoa.2014.136","relation":{},"ISSN":["2702-3648"],"issn-type":[{"value":"2702-3648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,1]]}}}