{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T20:39:12Z","timestamp":1777063152764,"version":"3.51.4"},"reference-count":8,"publisher":"Walter de Gruyter GmbH","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Context<\/jats:bold>: Peyronie disease (PD) is a connective tissue disorder involving the formation of fibrous plaques in the tunica albuginea. Abnormal plaques and scar tissue create a chronic state of inflammation, causing increased curvature of the penis as well as erectile dysfunction.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Objective<\/jats:bold>: To determine the feasibility and effects of using placental matrix\u2013derived mesenchymal stem cells (PM-MSCs) in the management of PD.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods<\/jats:bold>: In a prospective study, patients with PD were injected with PM-MSCs, and followed up at 6-week, 3-month, and 6-month intervals to assess changes in plaque volume, penile curvature, and erectile function status (measured using peak systolic velocity, end-diastolic velocity, and the International Index of Erectile Function questionnaire).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results<\/jats:bold>: In the 5 patients enrolled in the study, statistically significant increases in peak systolic velocity occurred after PM-MSC injection (<jats:italic>P<\/jats:italic>&lt;.01). Of a total of 10 plaques managed, 7 had disappeared completely at 3-month follow-up. Changes in end-diastolic velocity, stretched penile length, and penile girth were not statistically significant.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion<\/jats:bold>: To our knowledge, this study is the first on the use of stem cells to manage PD in humans. The results suggest that PM-MSCs may be beneficial and effective as a nonsurgical treatment in patients with PD. Future studies with long-term follow-up in a larger sample of patients are warranted. (ClinicalTrials.gov number NCT02395029)<\/jats:p>","DOI":"10.7556\/jaoa.2015.124","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T13:31:09Z","timestamp":1443447069000},"page":"e8-e13","source":"Crossref","is-referenced-by-count":40,"title":["Effects of Stem Cell Treatment in Human Patients With Peyronie Disease"],"prefix":"10.1515","volume":"115","author":[{"given":"Jason A.","family":"Levy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Marchand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Zribi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Zahalsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"issue":"8","key":"2022022614582462162_j_jaoa.2015.124_ref_001","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/ijcp.12129","article-title":"Understanding the course of Peyronie\u2019s disease","volume":"67","author":"Garaffa","year":"2013","journal-title":"Int J Clin Pract."},{"issue":"2","key":"2022022614582462162_j_jaoa.2015.124_ref_002","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000030220","article-title":"The relationship between diabetes mellitus, impotence and veno-occlusive dysfunction in Peyronie\u2019s disease patients","volume":"60","author":"Culha","year":"1998","journal-title":"Urologia Int."},{"issue":"1","key":"2022022614582462162_j_jaoa.2015.124_ref_003","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0022-5347(17)35997-9","article-title":"Penile vascular evaluation of men with Peyronie\u2019s disease","volume":"149","author":"Lopez","year":"1993","journal-title":"J Urol."},{"issue":"11","key":"2022022614582462162_j_jaoa.2015.124_ref_004","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1242\/jcs.02932","article-title":"Mesenchymal stem cells reside in virtually all post-natal organs and tissues","volume":"119","author":"da","year":"2006","journal-title":"J Cell Sci."},{"issue":"3","key":"2022022614582462162_j_jaoa.2015.124_ref_005","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","article-title":"A perivascular origin for mesenchymal stem cells in multiple human organs","volume":"3","author":"Crisan","year":"2008","journal-title":"Cell Stem Cell."},{"key":"2022022614582462162_j_jaoa.2015.124_ref_006","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-94-007-2828-8_18","article-title":"Adipose-derived stem cells: therapy through paracrine actions. In: Hayat MA, ed","volume":"4","author":"Lin","year":"2012","journal-title":"Stem Cells and Cancer Stem Cells"},{"issue":"3","key":"2022022614582462162_j_jaoa.2015.124_ref_007","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.eururo.2012.09.034","article-title":"Intratunical injection of human adipose tissue-derived stem cells prevents fibrosis and is associated with improved erectile function in a rat model of Peyronie\u2019s disease","volume":"63","author":"Castiglione","year":"2013","journal-title":"Eur Urol."},{"issue":"2","key":"2022022614582462162_j_jaoa.2015.124_ref_008","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.2047-2927.2013.00181.x","article-title":"Adipose tissue-derived stem cell therapy for prevention and treatment of erectile dysfunction in a rat model of Peyronie\u2019s disease","volume":"2","author":"Gokce","year":"2014","journal-title":"Andrology."}],"container-title":["Journal of Osteopathic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.7556\/jaoa.2015.124\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.7556\/jaoa.2015.124\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T15:00:09Z","timestamp":1645887609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.7556\/jaoa.2015.124\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,1]]},"references-count":8,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,1]]},"published-print":{"date-parts":[[2015,10,1]]}},"alternative-id":["10.7556\/jaoa.2015.124"],"URL":"https:\/\/doi.org\/10.7556\/jaoa.2015.124","relation":{},"ISSN":["2702-3648"],"issn-type":[{"value":"2702-3648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,1]]}}}