{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:37:53Z","timestamp":1791995873480,"version":"4.4.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Context<\/jats:bold>: Patients with diabetes are susceptible to heart failure. Defective mitochondria can cause cardiac damage. Mitochondrial autophagy or mitophagy is a quality control mechanism that eliminates dysfunctional mitochondria through lysosome degradation. Mitophagy is essential for maintaining a pool of healthy mitochondria for normal cardiac function. However, the effect of diabetes on the functional status of cardiac mitophagy remains unclear.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To determine and compare cardiac mitophagy flux between diabetic and nondiabetic mice.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Using a novel dual fluorescent mitophagy reporter termed <jats:italic>mt-Rosella<\/jats:italic>, we labeled and traced mitochondrial fragments that are sequestered by the autophagosome and delivered to and degraded in the lysosome.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Mitophagic activity was reduced in high-glucose\u2013treated cardiomyocytes and in the heart tissue of type 1 diabetic mice.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Mitophagy was impaired in the heart of diabetic mice, suggesting that restoring or accelerating mitophagy flux may be a useful strategy to reduce cardiac injury caused by diabetes.<\/jats:p>","DOI":"10.7556\/jaoa.2020.072","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T16:34:37Z","timestamp":1593448477000},"page":"446-455","source":"Crossref","is-referenced-by-count":11,"title":["Novel Dual-Fluorescent Mitophagy Reporter Reveals a Reduced Mitophagy Flux in Type 1 Diabetic Mouse 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