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In this case report, we describe a 13-year-old girl with sickle cell disease who presented to the emergency department after a morphine overdose causing renal infarction, acute kidney injury, acute respiratory distress syndrome, and posterior reversible encephalopathy syndrome.<\/jats:p>","DOI":"10.7556\/jaoa.2020.125","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T16:51:08Z","timestamp":1598892668000},"page":"770-773","source":"Crossref","is-referenced-by-count":1,"title":["Opioid-Induced Sickle Cell Crisis With Multiple, Life-threatening Complications"],"prefix":"10.1515","volume":"120","author":[{"given":"Ashley Griswold","family":"Haggerty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Koons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Beauchamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"issue":"6","key":"2021032622405055065_j_jaoa.2020.125_ref_001_w2aab3b7c27b1b6b1ab2ab1Aa","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.pcl.2013.09.006","article-title":"Sickle cell disease in childhood: from newborn screening through transition to adult medical care","volume":"60","year":"2013","journal-title":"Pediatr Clin North Am"},{"issue":"5","key":"2021032622405055065_j_jaoa.2020.125_ref_002_w2aab3b7c27b1b6b1ab2ab2Aa","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/pbc.20403","article-title":"Opioid selection during sickle cell pain crisis and its impact on the development of acute chest syndrome","volume":"45","year":"2005","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"2021032622405055065_j_jaoa.2020.125_ref_003_w2aab3b7c27b1b6b1ab2ab3Aa","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/pbc.20403","article-title":"The basic pharmacology of opioids informs the opioid discourse about misuse and abuse: a review","volume":"6","year":"2017","journal-title":"Pain Ther"},{"key":"2021032622405055065_j_jaoa.2020.125_ref_004_w2aab3b7c27b1b6b1ab2ab4Aa","first-page":"ES9","article-title":"Opioid epidemic in the United States","volume":"15","year":"2012","journal-title":"Pain Physician"},{"issue":"1","key":"2021032622405055065_j_jaoa.2020.125_ref_005_w2aab3b7c27b1b6b1ab2ab5Aa","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/j.amepre.2016.02.012","article-title":"Chronic opioid therapy and central sensitization in sickle cell disease","volume":"51","year":"2016","journal-title":"Am J Prev Med"},{"issue":"10","key":"2021032622405055065_j_jaoa.2020.125_ref_006_w2aab3b7c27b1b6b1ab2ab6Aa","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1093\/pm\/pnw074","article-title":"The opioid drug epidemic and sickle cell disease: guilt by association","volume":"17","year":"2016","journal-title":"Pain Med"},{"key":"2021032622405055065_j_jaoa.2020.125_ref_007_w2aab3b7c27b1b6b1ab2ab7Aa","unstructured":"National Institutes of Health. 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