{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:06:36Z","timestamp":1790856396160,"version":"4.1.0"},"reference-count":57,"publisher":"BioExcel","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DIC"],"abstract":"<jats:p>Osteoarthritis (OA) significantly impairs mobility and quality of life, with its prevalence rising due to ageing populations. Intra-articular hyaluronic acid (HA) injections, or viscosupplementation, restore synovial fluid viscosity, enhancing lubrication and joint function. Hymovis\u00ae\/Hymovis ONE\u00ae*, an advanced HA-based viscosupplement, incorporates hydrophobic modifications via MO.RE. technology, forming a reversible network that enhances viscoelasticity and lubrication. Hymovis exhibits self-healing properties, retaining elasticity and viscosity under mechanical stress, and demonstrates enhanced resistance to oxidative damage and enzymatic degradation. Evidence also supports its shock absorption and lubricating efficacy, which may exceed that of some cross-linked HA products. Clinical trials confirm its effectiveness in reducing OA-related pain and improving function in the knee, shoulder and hip. Additionally, Hymovis supports meniscal healing, as evidenced by MRI, highlighting its role in conservative meniscal tear management. In sports medicine, Hymovis alleviates joint overuse injuries, reducing pain, enhancing function, and potentially delaying OA progression. Hymovis ONE, specifically indicated for mild-to-moderate knee and hip OA, offers a single-injection solution with long-term benefits. Limitations of this narrative review include a predominance of observational studies and relatively small sample sizes in some clinical trials. Nonetheless, current evidence suggests that Hymovis\/Hymovis ONE represent effective intra-articular viscosupplementation options, leveraging MO.RE. technology to improve HA properties. Their clinical efficacy and safety make them valuable for OA management, meniscal injury treatment and joint health maintenance in active individuals, ultimately contributing to improved quality of life.\n\n*Hymovis\u00ae, Hymovis ONE\u00ae and HYADD4 are registered trademarks of Fidia Farmaceutici SpA, Italy.\n\nDownload the Plain Language Summary of this article: https:\/\/www.drugsincontext.com\/plain-language-summaries\/plain-language-summary-rheological-properties-and-clinical-efficacy-of-a-chemically-modified-hyaluronic-acid-for-joint-health-enhancement<\/jats:p>","DOI":"10.7573\/dic.2025-10-4","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:57:11Z","timestamp":1774616231000},"page":"1","source":"Crossref","is-referenced-by-count":0,"title":["Rheological properties and clinical efficacy of a chemically modified hyaluronic acid for joint health enhancement"],"prefix":"10.7573","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5152-1082","authenticated-orcid":false,"given":"Francesco","family":"Benazzo","sequence":"first","affiliation":[{"name":"Fondazione Poliambulanza Brescia - IUSS Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0204-9831","authenticated-orcid":false,"given":"Andrea","family":"Bernetti","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03fc1k060","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Salento"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10047","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1.\tAltman RD, Manjoo A, Fierlinger A, Niazi F, Nicholls M. The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review. BMC Musculoskelet Disord. 2015;16:321. https:\/\/doi.org\/10.1186\/s12891-015-0775-z","DOI":"10.1186\/s12891-015-0775-z"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"2.\tNicholls M, Manjoo A, Shaw P, Niazi F, Rosen J. Rheological properties of commercially available hyaluronic acid products in the United States for the treatment of osteoarthritis knee pain. Clin Med Insights Arthritis Musculoskelet Disord. 2018;11:1179544117751622. https:\/\/doi.org\/10.1177\/1179544117751622","DOI":"10.1177\/1179544117751622"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"3.\tColeman PJ, Scott D, Mason RM, Levick JR. Role of hyaluronan chain length in buffering interstitial flow across synovium in rabbits. J Physiol. 2000;526:425\u2013434. https:\/\/doi.org\/10.1111\/j.1469-7793.2000.00425.x","DOI":"10.1111\/j.1469-7793.2000.00425.x"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"4.\tSmith MM, Ghosh P. The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of hyaluronate in the extracellular environment. Rheumatol Int. 1987;7:113\u2013122. https:\/\/doi.org\/10.1007\/BF00270463","DOI":"10.1007\/BF00270463"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"5.\tDom\u017calski M, Migliore A. A Review of the clinical effectiveness and safety of hybrid cooperative complexes in intra-articular viscosupplementation. Rheumatol Ther. 2022;9:957\u2013974. https:\/\/doi.org\/10.1007\/s40744-022-00450-z","DOI":"10.1007\/s40744-022-00450-z"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"6.\tMessina C, Guglielmi G, Orlandi D, Corazza A, Mauri G, Sconfienza LM. The role of joint viscosupplementation in geriatric population. Curr Radiol Rep. 2017;5:1. https:\/\/doi.org\/10.1007\/s40134-017-0196-x","DOI":"10.1007\/s40134-017-0196-x"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"7.\tWobig M, Bach G, Beks P, et al. The role of elastoviscosity in the efficacy of viscosupplementation for osteoarthritis of the knee: a comparison of hylan G-F 20 and a lower-molecular-weight hyaluronan. Clin Ther. 1999;21:1549\u20131562. https:\/\/doi.org\/10.1016\/s0149-2918(00)80010-7","DOI":"10.1016\/S0149-2918(00)80010-7"},{"key":"ref7","unstructured":"8.\tBalazs EA, Leschiner A, Larsen N, Band P, inventors; Biomatrix Inc, assignee. Hylan preparation and method of recovery thereof from animal tissues. US patent 5,099,013, 1992."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"9.\tMore S, Kotiya A, Kotia A, Ghosh SK, Spyrou LA, Sarris IE. Rheological properties of synovial fluid due to viscosupplements: a review for osteoarthritis remedy. Comput Methods Programs Biomed. 2020;196:105644. https:\/\/doi.org\/10.1016\/j.cmpb.2020.105644","DOI":"10.1016\/j.cmpb.2020.105644"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"10.\tWu YZ, Huang HT, Ho CJ, et al. Molecular weight of hyaluronic acid has major influence on its efficacy and safety for viscosupplementation in hip osteoarthritis: a systematic review and meta-analysis. Cartilage. 2021;13:169S-184S. https:\/\/doi.org\/10.1177\/19476035211021903","DOI":"10.1177\/19476035211021903"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"11.\tPelletier S, Hubert P, Payan E, Marchal, P, Choplin, Dellacherie E. Amphiphilic derivatives of sodium alginate and hyaluronate for cartilage repair: rheological properties. J Biomed Mater Res. 2001;54:102\u2013108. https:\/\/ doi.org\/10.1002\/1097-4636(200101)54:1<102::aid-jbm12>3.0.co;2-1","DOI":"10.1002\/1097-4636(200101)54:1<102::AID-JBM12>3.0.CO;2-1"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"12.\tCreuzet C, Kadi S, Rinaudo M, Auzely-Velty, R. New associative systems based on alkylated hyaluronic acid. Synthesis and aqueous solution properties. Polymer. 2006;47:2706\u20132713. https:\/\/doi.org\/10.1016\/j.polymer. 2006.02.052","DOI":"10.1016\/j.polymer.2006.02.052"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"13.\tFinelli I, Chiessi E, Galesso D, Renier D, Paradossi G. Gel-like structure of a hexadecyl derivative of hyaluronic acid for the treatment of osteoarthritis. Macromol Biosci. 2009;9:646\u2013653. https:\/\/doi.org\/10.1002\/mabi.200900009","DOI":"10.1002\/mabi.200900009"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"14.\tFinelli I, Chiessi E, Galesso D, Renier D, Paradossi G. A new viscosupplement based on partially hydrophobic hyaluronic acid: a comparative study. Biorheology. 2011;48:263\u2013275. https:\/\/doi.org\/10.3233\/BIR-2011-0596","DOI":"10.3233\/BIR-2011-0596"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"15.\tGoldberg VM, Goldberg L. Intra-articular hyaluronans: the treatment of knee pain in osteoarthritis. J Pain Res. 2010;3:51\u201356. https:\/\/doi.org\/10.2147\/jpr.s4733","DOI":"10.2147\/JPR.S4733"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"16.\tGreenwald RA. Oxygen radicals, inflammation, and arthritis \u2013 pathophysiological considerations and implications for treatment. Semin Arthritis Rheum. 1991;20:219\u2013240. https:\/\/doi.org\/10.1016\/0049-0172(91)90018-u","DOI":"10.1016\/0049-0172(91)90018-U"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"17.\tPavan M, Galesso D, Menon G, Renier D, Guarise C. Hyaluronan derivatives: alkyl chain length boosts viscoelastic behavior to depolymerization. Carbohydr Polym. 2013;97:321\u2013326. https:\/\/doi.org\/10.1016\/j.carbpol.2013.04.090","DOI":"10.1016\/j.carbpol.2013.04.090"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"18.\tPavan M, Galesso D, Secchieri C, Guarise C. Hyaluronic acid alkyl derivative: a novel inhibitor of metalloproteases and hyaluronidases. Int J Biol Macromol. 2016;84:221\u2013226. https:\/\/doi.org\/10.1016\/j.ijbiomac.2015.12.003","DOI":"10.1016\/j.ijbiomac.2015.12.003"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"19.\tLi H, Wang D, Yuan Y, Min J. New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis. Arthritis Res Ther. 2017;19:248. https:\/\/doi.org\/10.1186\/s13075-017-1454-2","DOI":"10.1186\/s13075-017-1454-2"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"20.\tFalcinelli E, Giordan N, Luccioli F, et al. Randomized trial of Hymovis\u00ae versus Synvisc\u00ae on matrix metalloproteinases in knee osteoarthritis. Muscles Ligaments Tendons J 2020;10:553. https:\/\/doi.org\/10.32098\/mltj.04.2020.02","DOI":"10.32098\/mltj.04.2020.02"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"21.\tPeck J, Slovek A, Miro P, et al. A comprehensive review of viscosupplementation in osteoarthritis of the knee. Orthop Rev. 2021;13:25549. https:\/\/doi.org\/10.52965\/001c.25549","DOI":"10.52965\/001c.25549"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"22.\tBonnevie ED, Galesso D, Secchieri C, Bonassar JL. Frictional characterization of injectable hyaluronic acids is more predictive of clinical outcomes than traditional rheological or viscoelastic characterization. PLoS One. 2019;14:e0216702. https:\/\/doi.org\/10.1371\/journal.pone.0216702","DOI":"10.1371\/journal.pone.0216702"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"23.\tBonnevie ED, Galesso D, Secchieri C, Bonassar JL. Degradation alters the lubrication of articular cartilage by high viscosity, hyaluronic acid-based lubricants. J Orthop Res. 2018;36:1456\u20131464. https:\/\/doi.org\/10.1002\/jor.23782","DOI":"10.1002\/jor.23782"},{"key":"ref23","unstructured":"24.\tBenazzo F, Perticarini L, Padolino A, et al. A multi-centre, open label, long-term follow-up study to evaluate the benefits of a new viscoelastic hydrogel Hymovis\u00ae) in the treatment of knee osteoarthritis. Eur Rev Med Pharmacol Sci. 2016;20:959\u2013968."},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"25.\tPriano F. Early efficacy of intra-articular HYADD\u00ae 4 (Hymovis\u00ae) injections for symptomatic knee osteoarthritis. Joints. 2017;5:79\u201384. https:\/\/doi.org\/10.1055\/s-0037-1603677","DOI":"10.1055\/s-0037-1603677"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"26.\tPorcellini G, Merolla G, Giordan N, et al. Intra-articular glenohumeral injections of HYADD\u00ae4-G for the treatment of painful shoulder osteoarthritis: a prospective multicenter, open-label trial. Joints. 2016;3:116\u2013121. https:\/\/doi.org\/10.11138\/jts\/2015.3.3.116","DOI":"10.11138\/jts\/2015.3.3.116"},{"key":"ref26","unstructured":"27.\tBisicchia S, Bernardi G, Tudisco C. HYADD 4 versus methylprednisolone acetate in symptomatic knee osteoarthritis: a single-centre single blind prospective randomised controlled clinical study with 1-year follow-up. Clin Exp Rheumatol. 2016;34:857\u2013863."},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"28.\tDi Giacomo G, de Gasperis N. Hymovis\u00ae Intra-articular injections vs corticosteroids intra-articular injections in patients affected by glenohumeral osteoarthritis: a monocentric randomized open-label trial. J Biol Regulators Homeostatic Agents. 2023;37:6525\u20136534. https:\/\/doi.org\/10.23812\/j.biol.regul.homeost.agents.20233712.617","DOI":"10.23812\/j.biol.regul.homeost.agents.20233712.617"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"29.\tZorzi C, Rigotti S, Screpis D, Giordan N, Piovan G. A new hydrogel for the conservative treatment of meniscal lesions: a randomized controlled study. Joints. 2016;3:136\u2013145. https:\/\/doi.org\/10.11138\/jts\/2015.3.3.136","DOI":"10.11138\/jts\/2015.3.3.136"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"30.\tBerton A, Longo UG, Candela V, et al. Quantitative evaluation of of meniscal healing process of degenerative meniscus lesions treated with hyaluronic acid: a clinical and MRI study. J Clin Med. 2020;9:2280. https:\/\/doi.org\/10.3390\/jcm9072280","DOI":"10.3390\/jcm9072280"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"31.\tBernetti A, Mangone M, Paolucci T, et al. Evaluation of the efficacy of intra-articular injective treatment with reticular hyaluronic acid (Mo.Re. Technology) in amateur athletes with over-use gonarthrosis. Med Sport. 2020;73:127\u2013139. https:\/\/doi.org\/10.23736\/S0025-7826.20.03648-0","DOI":"10.23736\/S0025-7826.20.03648-0"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"32.\tBernetti A, Agostini F, Alviti F, et al. New viscoelastic hydrogel Hymovis MO.RE. single intra-articular injection for the treatment of knee osteoarthritis in sportsmen: safety and efficacy study results. Front Pharmacol. 2021;12:673988. https:\/\/doi.org\/10.3389\/fphar.2021.673988","DOI":"10.3389\/fphar.2021.673988"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"33.\tGBD 2021 Osteoarthritis Collaborators. Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5:e508\u2013e522. https:\/\/doi.org\/10.1016\/S2665-9913(23)00163-7","DOI":"10.1016\/S2665-9913(23)00163-7"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"34.\tMigliore A, Frediani B, Gigliucci G, et al. Efficacy of a single intra-articular HYMOVIS ONE injection for managing symptomatic hip osteoarthritis: a 12-month follow-up retrospective analysis of the ANTIAGE Register data. Orthop Res Rev. 2020;12:19\u201326. https:\/\/doi.org\/10.2147\/ORR.S239355","DOI":"10.2147\/ORR.S239355"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"35.\tRussu OM, Pop TS, Feier AM, et al. Treatment efficacy with a novel hyaluronic acid-based hydrogel for osteoarthritis of the knee. J Pers Med. 2021;11:303. https:\/\/doi.org\/10.3390\/jpm11040303","DOI":"10.3390\/jpm11040303"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"36.\tMeehan RT, Gill MT, Hoffman ED, et al. Ultrasound-guided injections of HYADD4 for knee osteoarthritis improves pain and functional outcomes at 3, 6, and 12 months without changes in measured synovial fluid, serum collagen biomarkers, or most synovial fluid biomarker proteins at 3 months. J Clin Med. 2023;12:5541. https:\/\/doi.org\/10.3390\/ jcm12175541","DOI":"10.3390\/jcm12175541"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"37.\tPavelka K, Bernetti A, Giordan N, et al. Dose-response of hyaluronate-based viscoelastic hydrogels for the treatment of knee osteoarthrosis: a prospective, randomized, comparative clinical trial. Minerva Ortop Traumatol. 2020;71:45\u201355. https:\/\/doi.org\/10.23736\/S0394-3410.20.03967-3","DOI":"10.23736\/S0394-3410.20.03967-3"},{"key":"ref37","unstructured":"38.\tClinicaltrials.gov. Comparative study of two hyaluronic acid formulation in the management of knee osteoarthritis. NCT06528600. https:\/\/clinicaltrials.gov\/study\/NCT06528600"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"39.\tHenrotin Y, Bannuru R, Malaise M, et al. Hyaluronan derivative HYMOVIS\u00ae increases cartilage volume and type ii collagen turnover in osteoarhritic knee: data from MOKHA study. BMC Muscoloskelet Disord. 2019;20:293. https:\/\/doi. org\/10.1186\/s12891-019-2667-0","DOI":"10.1186\/s12891-019-2667-0"},{"key":"ref39","unstructured":"40.\tPerticarini L, Baldari A, Bruzzone M, et al. Hymovis MO.RE. in the treatment of knee and ankle chondropathy in elite athletes: preliminary results of the CHAMPS (Cohort study about HYADD4-G Administration for Pain relief on Soccer players) prospective clinical study. Eur Rev Med Pharmacol Sci. 2021;25:6356\u20136364. https:\/\/doi.org\/10.26355\/ eurrev_202110_27009"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"41.\tRando G, Pastorino R. Intra-articular Hymovis injection for managing hip OA in active sportsmen. A 24-month observational retrospective clinical investigation. J Clin Orthop Trauma. 2021;22:101594. https:\/\/doi.org\/10.1016\/j. jcot.2021.101594","DOI":"10.1016\/j.jcot.2021.101594"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"42.\tDe Marziani L, Sangiorgio A, Bensa Andriolo L, Filardo G. Intra-articular injections in sport-active patients with degenerative cartilage lesions or osteoarthritis of the knee: a systematic review. J Exp Orthop. 2023;10:112. https:\/\/doi.org\/10.1186\/s40634-023-00674-0","DOI":"10.1186\/s40634-023-00674-0"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"43.\tPesare E, Vicenti G, Kon E, et al. Italian orthopaedic and traumatology society (SIOT) position statement on the non-surgical management of knee osteoarthritis. J Orthop Traumatol. 2023;24:47. https:\/\/doi.org\/10.1186\/s10195- 023-00729-z","DOI":"10.1186\/s10195-023-00729-z"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"44.\tJiang X, Sun Y, Lyu Y, et al. Hydrogels for ameliorating osteoarthritis: mechanical modulation, anti-inflammation, and regeneration. BMEMat. 2024;2:e12078. https:\/\/doi.org\/10.1002\/bmm2.12078","DOI":"10.1002\/bmm2.12078"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"45.\tMigliore A, Maheu E, Saccone L, et al. What we should expect from an innovative intra-articular hyaluronic acid product: expert opinion based on a comprehensive review of the literature. J Clin Med. 2023;12:7422. https:\/\/doi.org\/10.3390\/jcm12237422","DOI":"10.3390\/jcm12237422"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"46.\tScanu A, Luisetto R, Pavan M, et al. Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus in rats. Sci Rep. 2023;13:20692. https:\/\/doi.org\/10.1038\/s41598-023-46965-5","DOI":"10.1038\/s41598-023-46965-5"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"47.\tMigliore A, Gigliucci G, Alekseeva L, et al. Systematic literature review and expert opinion for the use of viscosupplementation with hyaluronic acid in different localizations of osteoarthritis. Orthop Res Rev. 2021;13:255\u2013 273. https:\/\/doi.org\/10.2147\/ORR.S336185","DOI":"10.2147\/ORR.S336185"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"48.\tChang A, Moisio K, Chmiel JS, et al. Subregional effects of meniscal tears on cartilage loss over 2 years in knee osteoarthritis. Ann Rheum Dis. 2011;70:74\u201379. https:\/\/doi.org\/10.1136\/ard.2010.130278","DOI":"10.1136\/ard.2010.130278"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"49.\tEnglund M, Guermazi A, Roemer FW, et al. Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: the multicenter osteoarthritis study. Arthritis Rheum. 2009;60:831\u2013839. https:\/\/doi.org\/10.1002\/art.24383","DOI":"10.1002\/art.24383"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"50.\tFranceschi F, Longo UG, Ruzzini L, Marinozzi A, Maffulli N, Denaro V. Simultaneous arthroscopic implantation of autologous chondrocytes and high tibial osteotomy for tibial chondral defects in the varus knee. Knee. 2008;15:309\u2013313. https:\/\/doi.org\/10.1016\/j.knee.2008.04.007","DOI":"10.1016\/j.knee.2008.04.007"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"51.\tLongo UG, King JB, Denaro V, et al. Double-bundle arthroscopic reconstruction of the anterior cruciate ligament: does the evidence add up? J Bone Joint Surg Br. 2008;90:995\u2013999. https:\/\/doi.org\/10.1302\/0301-620X.90B8.20083","DOI":"10.1302\/0301-620X.90B8.20083"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"52.\tLongo UG, Ciuffreda M, Candela V, et al. Knee osteoarthritis after arthroscopic partial meniscectomy: prevalence and progression of radiographic changes after 5 to 12 years compared with contralateral knee. J Knee Surg. 2019;32:407\u2013413. https:\/\/doi.org\/10.1055\/s-0038-1646926","DOI":"10.1055\/s-0038-1646926"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"53.\tFaucett SC, Geisler BP, Chahla J, et al. Meniscus root repair vs meniscectomy or nonoperative management to prevent knee osteoarthritis after medial meniscus root tears: clinical and economic effectiveness. Am J Sports Med. 2019;47:762\u2013769. https:\/\/doi.org\/10.1177\/0363546518755754","DOI":"10.1177\/0363546518755754"},{"key":"ref53","unstructured":"54.\tPaoloni M, Bernetti A, Belelli A, et al. Appropriateness of clinical and organizational criteria for intra-articular injection therapies in osteoarthritis. A Delphi method consensus initiative among experts in Italy. Ann Ist Super Sanita. 2015;51:131\u2013138. https:\/\/doi.org\/10.4415\/ANN_15_02_11"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"55.\tGress K, Charipova K, An D, et al. Treatment recommendations for chronic knee osteoarthritis. Best Pract Res Clin Anaesthesiol. 2020;34:369\u2013382. https:\/\/doi.org\/10.1016\/j.bpa.2020.06.006","DOI":"10.1016\/j.bpa.2020.06.006"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"56.\tArden NK, Perry TA, Bannuru RR, et al. Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines. Nat Rev Rheumatol. 2021;17:59\u201366. https:\/\/doi.org\/10.1038\/s41584-020-00523-9","DOI":"10.1038\/s41584-020-00523-9"},{"key":"ref56","unstructured":"57.\tTamburrino P, Castellacci E. Intra-articular injections of HYADD4-G in male professional soccer players with traumatic or degenerative knee chondropathy. A pilot, prospective study. 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