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Behavioral assessments were conducted to evaluate anxiety and cognitive function. To explore the underlying mechanisms, we measured the phosphorylated levels of extracellular signal-regulated kinase (ERK), cyclic adenosine monophosphate response-binding protein (CREB), protein kinase (AKT), adenosine monophosphate activated protein kinase (AMPK), synapsin (S9, S549, S609), and PSD-95 in the cortex, as these are associated with synaptic strength. Additionally, the expression of doublecortin (DCX), a neurogenic factor, was analyzed in the hippocampus.Results: Exercise led to reductions in depressive and anxiety-related behaviors and elevated the levels of phosphorylated ERK, CREB, AKT, AMPK, synapsin (S9, S549, S609), and PSD-95 in the cortex of young mice. Furthermore, exercise increased DCX expression in the hippocampus. Moderate-intensity exercise yielded more pronounced effects than other intensities.Conclusion: The findings of this research indicate that consistent moderate-intensity exercise increases synaptic strength and reduces depression and anxiety in young mice by activating multiple factors.<\/jats:p>","DOI":"10.7586\/jkbns.25.006","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T04:56:33Z","timestamp":1746680193000},"page":"213-223","update-policy":"https:\/\/doi.org\/10.7586\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effects of different intensities of aerobic exercise for 8 weeks on neurogenesis, depression, and anxiety in young mice"],"prefix":"10.7586","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5058-9912","authenticated-orcid":true,"given":"Mi 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