{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:18:37Z","timestamp":1793809117187,"version":"4.6.1"},"reference-count":48,"publisher":"Wildlife Disease Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Wildlife Diseases"],"published-print":{"date-parts":[[2021,1,6]]},"abstract":"<jats:p>Leptospirosis is reported infrequently in wild and domestic felids. We estimated the prevalence of Leptospira spp. infection and exposure using real-time PCR and serology, respectively, in 136 mountain lions (Puma concolor) and 39 bobcats (Lynx rufus) that died or were euthanized between 2009 and 2017 from several regions of California, US. Felids were classified as Leptospira-positive if they were test-positive using real-time PCR targeting the LipL32 gene of pathogenic Leptospira spp. or microscopic agglutination test for six serovars of Leptospira spp. The overall Leptospira spp. prevalence was 46% (63\/136) for mountain lions and 28% (11\/39) for bobcats. The most common serovar detected in both felid species was Leptospira interrogans serovar Pomona. Age class and geographic location were significantly associated with Leptospira spp. in mountain lions, but not in bobcats. Interstitial nephritis, predominately lymphocytic, was diagnosed in 39% (41\/106) of mountain lions and 16% (4\/25) of bobcats evaluated histologically and was significantly associated with being Leptospira spp.-positive in both species. Our findings suggest that Leptospira spp. infection is common and widespread in California's wild felids and may have clinical impacts on renal and overall health of individuals. Key words: Bobcat, Leptospira spp., leptospirosis, Lynx rufus, mountain lion, nephritis, pathology, Puma concolor.<\/jats:p>","DOI":"10.7589\/jwd-d-20-00070","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T11:14:03Z","timestamp":1602501243000},"page":"27-39","source":"Crossref","is-referenced-by-count":10,"title":["LEPTOSPIRA PREVALENCE AND ITS ASSOCIATION WITH RENAL PATHOLOGY IN MOUNTAIN LIONS (PUMA CONCOLOR) AND BOBCATS (LYNX RUFUS) IN CALIFORNIA, USA"],"prefix":"10.7589","volume":"57","author":[{"given":"Mary H.","family":"Straub","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime L.","family":"Rudd","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie W.","family":"Woods","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, Davis, PO Box 1770, Davis, California 95617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deana L.","family":"Clifford","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E.","family":"Foley","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4415","reference":[{"key":"31","unstructured":"et al.  \"R: A Language and Environment for Statistical Computing.\"  ,  (2015)"},{"key":"4","doi-asserted-by":"crossref","unstructured":"SN Bevins, S Carver, EE Boydston, et al.  \"PLoS One.\"  7, \"Three pathogens in sympatric populations of pumas, bobcats, and domestic cats: Implications for infectious disease transmission.\" e31403 (2012)","DOI":"10.1371\/journal.pone.0031403"},{"key":"38","doi-asserted-by":"crossref","unstructured":"R Ruppanner, DA Jessup, I Ohishi, et al.  \"J Am Vet Med Assoc.\"  181, \"Serologic survey for certain zoonotic diseases in black bears in California.\" 1288 (1982)","DOI":"10.2460\/javma.1982.181.11.1288"},{"key":"33","doi-asserted-by":"crossref","unstructured":"SPD Riley, C Bromley, RH Poppenga, et al.  \"J Wildl Manage.\"  71, \"Anticoagulant exposure and notoedric mange in bobcats and mountain lions in urban southern California.\" 1874 (2007)","DOI":"10.2193\/2005-615"},{"key":"1","doi-asserted-by":"crossref","unstructured":"CA Agunloye  and AS Nash  \"J Small Anim Pract.\"  37, \"Investigation of possible leptospiral infection in cats in Scotland.\" 126 (1996)","DOI":"10.1111\/j.1748-5827.1996.tb02360.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"WA. 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