{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T09:33:45Z","timestamp":1793439225609,"version":"4.5.0"},"reference-count":25,"publisher":"Wildlife Disease Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Wildlife Diseases"],"published-print":{"date-parts":[[2021,7,5]]},"abstract":"<jats:p>The variable response of wild mice to Yersinia pestis infection, the causative agent of plague, has generated much speculation concerning their role in the ecology of this potentially lethal disease. Researchers have questioned the means by which Y. pestis is maintained in nature and also sought methods for managing the disease. Here we assessed the efficacy of a new tool, the sylvatic plague vaccine (SPV), in wild-caught northern grasshopper mice (Onychomys leucogaster) and commercially acquired Sonoran deer mice (Peromyscus maniculatus sonoriensis). More than 40% of the animals survived a subcutaneous Y. pestis challenge of 175,000 colony forming units (over 30,000 times the white mouse 50% lethal dose) in both vaccine-treated and control groups. Our results indicate that SPV distribution is unlikely to protect adult mice from plague infection in field settings and corroborate the heterogeneous response to Y. pestis infection in mice reported by others.<\/jats:p>","DOI":"10.7589\/jwd-d-20-00122","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T09:54:51Z","timestamp":1625478891000},"page":"632-636","source":"Crossref","is-referenced-by-count":4,"title":["Moderate Susceptibility to Subcutaneous Plague (Yersinia pestis) Challenge in Vaccine-Treated and Untreated Sonoran Deer Mice (Peromyscus maniculatus sonoriensis) and Northern Grasshopper Mice (Onychomys leucogaster)"],"prefix":"10.7589","volume":"57","author":[{"given":"Gebbiena M.","family":"Bron","sequence":"first","affiliation":[{"name":"University of Wisconsin, School of Veterinary Medicine, Department of Pathobiological Sciences, 1656 Linden Drive, Madison, Wisconsin 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Smith","sequence":"additional","affiliation":[{"name":"US Geological Survey National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy D.","family":"Williamson","sequence":"additional","affiliation":[{"name":"US Geological Survey National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Tripp","sequence":"additional","affiliation":[{"name":"Colorado Parks and Wildlife, Wildlife Health Program, 4330 Laporte Avenue, Fort Collins, Colorado 80521, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonie E.","family":"Rocke","sequence":"additional","affiliation":[{"name":"US Geological Survey National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4415","reference":[{"key":"23","doi-asserted-by":"crossref","unstructured":"C Tollenaere, L Rahalison, M Ranjalahy, et al.  \"EcoHealth.\"  7, \"Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar.\" 242 (2010)","DOI":"10.1007\/s10393-010-0312-3"},{"key":"17","doi-asserted-by":"crossref","unstructured":"TE Rocke, DW Tripp, RE Russell, et al.  \"Ecohealth.\"  14, \"Sylvatic plague vaccine partially protects prairie dogs (Cynomys spp.) in field trials.\" 438 (2017)","DOI":"10.1007\/s10393-017-1253-x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"TM Therneau  and PM Grambsch  \"Modeling Survival Data: Extending the Cox Model.\"  , 350 (2000)","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"15","unstructured":"et al.  \"R: A language and environment for statistical computing.\"  ,  (2020)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"RC Abbott, R Hudak, R Mondesire, et al.  \"J Wildl Dis.\"  50, \"A rapid field test for sylvatic plague exposure in wild animals.\" 384 (2014)","DOI":"10.7589\/2013-07-174"},{"key":"2","doi-asserted-by":"crossref","unstructured":"KA Boegler, CB Graham, TL Johnson, et al.  \"J Med Entomol.\"  53, \"Infection prevalence, bacterial loads, and transmission efficiency in Oropsylla montana (Siphonaptera: Ceratophyllidae) one day after exposure to varying concentrations of Yersinia pestis in blood.\" 674 (2016)","DOI":"10.1093\/jme\/tjw004"},{"key":"3","doi-asserted-by":"crossref","unstructured":"GM Bron, KLD Richgels, MD Samuel, et al.  \"EcoHealth.\"  15, \"Impact of sylvatic plague vaccine on non-target small rodents in grassland ecosystems.\" 555 (2018)","DOI":"10.1007\/s10393-018-1334-5"},{"key":"4","doi-asserted-by":"crossref","unstructured":"J Domenico, JJ Lucas, M Fujita, et al.  \"Int Arch Allergy Immunol.\"  158, \"Susceptibility to vaccinia virus infection and spread in mice is determined by age at infection, allergen sensitization and mast cell status.\" 196 (2012)","DOI":"10.1159\/000330647"},{"key":"5","doi-asserted-by":"crossref","unstructured":"DM Engelthaler  and KL Gage  \"J Med Entomol.\"  37, \"Quantities of Yersinia pestis in fleas (Siphonaptera: Pulicidae, Ceratophyllidae, and Hystrichopsyllidae) collected from areas of known or suspected plague activity.\" 422 (2000)","DOI":"10.1093\/jmedent\/37.3.422"},{"key":"6","doi-asserted-by":"crossref","unstructured":"KL Gage  and MY Kosoy  \"Annu Rev Entomol.\"  50, \"Natural history of plague: Perspectives from more than a century of research.\" 505 (2005)","DOI":"10.1146\/annurev.ento.50.071803.130337"},{"key":"7","unstructured":"BJ. 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