{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:32:29Z","timestamp":1793421149740,"version":"4.5.0"},"reference-count":15,"publisher":"Wildlife Disease Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Wildlife Diseases"],"published-print":{"date-parts":[[2024,4,5]]},"abstract":"<jats:p>The purpose of this study was to determine if the number of pregnancies in naturally infected Brucella abortus\u2013positive bison (Bison bison) cows would be reduced over a period of 5 yr after one treatment with 3000 mg gonadotropin-releasing hormone immunocontraceptive (GonaCon) compared to a similar group of naturally infected B. abortus\u2013positive bison cows not treated with GonaCon. In each of the 5 yr, GonaCon-treated cows produced fewer offspring in relation to number of cows than the nontreated cows. Fisher's Exact test comparing offspring produced during the first reproductive season showed a significant difference between the two groups (P=0.0028). Differences in number of calves produced in GonaCon-treated and control groups were also noted in remaining years, but statistics were not applied because of data constraints. These data indicate that one treatment with GonaCon in brucellosis-seropositive female bison reduced pregnancies over five reproductive years. Thus, immunocontraception could potentially be used to manage brucellosis in affected herds.<\/jats:p>","DOI":"10.7589\/jwd-d-21-00168","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T13:45:31Z","timestamp":1713534331000},"page":"339-345","source":"Crossref","is-referenced-by-count":3,"title":["EFFECTS OF THE IMMUNOCONTRACEPTIVE GONACON ON PREGNANCY IN BRUCELLA-SEROPOSITIVE AMERICAN BISON (BISON BISON)"],"prefix":"10.7589","volume":"60","author":[{"given":"Rebecca K.","family":"Frey","sequence":"first","affiliation":[{"name":"United States Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services, 232 Cokedale Rd, Montana 59047, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan E.","family":"Wehtje","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services, 4101 Laporte Ave., Fort Collins, Colorado 80521, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Nol","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services, 4101 Laporte Ave., Fort Collins, Colorado 80521, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick R.","family":"Clarke","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services (retired), 1857 Brisk Court, Bozeman, Montana 59718, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack C.","family":"Rhyan","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services (retired), 10075 North County Rd 15, Fort Collins, Colorado 80524, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"McCollum","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services, 4101 Laporte Ave., Fort Collins, Colorado 80521, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lowell A.","family":"Miller","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, 4101 Laporte Ave., Fort Collins, Colorado 80521, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas C.","family":"Eckery","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, 4101 Laporte Ave., Fort Collins, Colorado 80521, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4415","reference":[{"key":"11","doi-asserted-by":"crossref","unstructured":"JC Rhyan, T Gidlewski, TJ Roffe, et al.  \"J Wildl Dis.\"  37, \"Pathology of brucellosis in bison from Yellowstone National Park.\" 101 (2001)","DOI":"10.7589\/0090-3558-37.1.101"},{"key":"9","doi-asserted-by":"crossref","unstructured":"JC Rhyan, K Aune, T Roffe, et al.  \"J Wildl Dis.\"  45, \"Pathogenesis and epidemiology of brucellosis in Yellowstone bison: Serologic and culture results from adult females and their progeny.\" 729 (2009)","DOI":"10.7589\/0090-3558-45.3.729"},{"key":"8","unstructured":"\"R: a language and environment for statistical computing.\"  (2020)"},{"key":"4","doi-asserted-by":"crossref","unstructured":"LA Miller, JC Rhyan, M Drew,  \"J Wildl Dis.\"  40, \"Contraception of bison by GnRH vaccine: A possible means of decreasing transmission of brucellosis in bison.\" 725 (2004)","DOI":"10.7589\/0090-3558-40.4.725"},{"key":"15","unstructured":"\"Final environmental impact statement for the interagency bison management plan for the State of Montana and Yellowstone National Park.\"  (2000)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"JA Fuller, RA Garrott, PJ White, et al.  \"J Wildl Manag.\"  71, \"Reproduction and survival of Yellowstone bison.\" 2365 (2006)","DOI":"10.2193\/2006-201"},{"key":"2","unstructured":"JH Koziol  and CL Armstrong  \"Society for Theriogenology manual for breeding soundness examination of bulls.\"  147 (2018)"},{"key":"3","doi-asserted-by":"crossref","unstructured":"LA Miller, JP Gionfriddo, KA Fagerstone, et al.  \"Am J Reprod Immunol.\"  60, \"The single-shot GnRH immunocontraceptive vaccine (GonaConTM) in white-tailed deer: Comparison of several GnRH preparations.\" 214 (2008)","DOI":"10.1111\/j.1600-0897.2008.00616.x"},{"key":"5","unstructured":"JR. Mohler,  \"Report of the Chief of the Bureau of Animal Industry, Pathological Division, Abortion Disease. Annual reports of the US Department of Agriculture.\"  105 (1917)"},{"key":"6","unstructured":"\"Revisiting Brucellosis in the Greater Yellowstone Area.\"  196 (2020)"},{"key":"7","doi-asserted-by":"crossref","unstructured":"P Nol, R Frey, M Wehtje, et al.  \"J Wildl Dis.\"  60, \"Brucellosis in bison and the effects of pregnancy prevention on disease transmission.\" 327 (2024)","DOI":"10.7589\/JWD-D-21-00167"},{"key":"10","unstructured":"JC Rhyan  and MD Drew  \"Brucellosis in elk and bison in the Greater Yellowstone Area Symposium.\"  \"Contraception: A possible means of decreasing transmission of brucellosis in bison.\" 99 (2002)"},{"key":"12","doi-asserted-by":"crossref","unstructured":"JC Rhyan, LA Miller, KA Fagerstone,  \"J Zoo Wildl Med.\"  44, \"The use of contraception as a disease management tool in wildlife.\" S135 (2013)","DOI":"10.1638\/1042-7260-44.4S.S135"},{"key":"13","unstructured":"KA Schoenecker, J Powers, JC Rhyan, et al.  \"6th Triennial American Bison Society Conference and Workshop, 28 October\u20132 November 2019, Pojoaque, New Mexico.\"  \"Efficacy of GonaCon immunocontraception in bison [Poster].\" (2019)"},{"key":"14","unstructured":"\"Brucellosis eradication: Uniform methods & rules, effective October 1, 2003.\"  91 (2003)"}],"container-title":["Journal of Wildlife Diseases"],"original-title":[],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:25:48Z","timestamp":1793420748000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/journal-of-wildlife-diseases\/volume-60\/issue-2\/JWD-D-21-00168\/EFFECTS-OF-THE-IMMUNOCONTRACEPTIVE-GONACON-ON-PREGNANCY-IN-BRUCELLA-SEROPOSITIVE\/10.7589\/JWD-D-21-00168.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,5]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,4,1]]}},"URL":"https:\/\/doi.org\/10.7589\/jwd-d-21-00168","relation":{},"ISSN":["0090-3558","1943-3700"],"issn-type":[{"value":"0090-3558","type":"print"},{"value":"1943-3700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,5]]}}}