{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:33:23Z","timestamp":1793424803743,"version":"4.5.0"},"reference-count":22,"publisher":"Wildlife Disease Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Wildlife Diseases"],"published-print":{"date-parts":[[2023,10,24]]},"abstract":"<jats:p>Respiratory disease is a significant barrier for bighorn sheep (Ovis canadensis) conservation, and a need remains for management options in both captive and free-ranging populations. We treated Mycoplasma ovipneumoniae infection in six bighorn lambs and five bighorn yearlings at two captive research facilities with twice daily oral doxycycline for 8 wk or longer. Doses of 5 mg\/kg twice daily mixed in formula for lambs and 10 mg\/kg twice daily mixed in moistened pellets for older lambs and yearlings were tolerated well with minimal side effects. All animals in this case report remain Mycoplasma ovipneumoniae free over 2 yr later. Further evaluation is warranted to confirm efficacy of this therapeutic approach.<\/jats:p>","DOI":"10.7589\/jwd-d-22-00094","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T06:36:28Z","timestamp":1698129388000},"page":"753-758","source":"Crossref","is-referenced-by-count":5,"title":["Clearance of Mycoplasma ovipneumoniae in Captive Bighorn Sheep (Ovis canadensis) Following Extended Oral Doxycycline Treatment"],"prefix":"10.7589","volume":"59","author":[{"given":"Mary E.","family":"Wood","sequence":"first","affiliation":[{"name":"Colorado Parks and Wildlife, Wildlife Health Program, 4330 Laporte Ave., Fort Collins, Colorado 80521, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Wyoming Game and Fish Department, Veterinary Services, Wildlife Health Laboratory, 1174 Snowy Range Rd., Laramie, Wyoming 82070, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Jennings-Gaines","sequence":"additional","affiliation":[{"name":"Wyoming Game and Fish Department, Veterinary Services, Wildlife Health Laboratory, 1174 Snowy Range Rd., Laramie, Wyoming 82070, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah","family":"Gaston","sequence":"additional","affiliation":[{"name":"Wyoming Game and Fish Department, Veterinary Services, Thorne-Williams Wildlife Research Center, 2362 WY-34, Wheatland, Wyoming 82201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peach","family":"Van Wick","sequence":"additional","affiliation":[{"name":"Wyoming Game and Fish Department, Veterinary Services, Thorne-Williams Wildlife Research Center, 2362 WY-34, Wheatland, Wyoming 82201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sierra","family":"Amundson","sequence":"additional","affiliation":[{"name":"Colorado Parks and Wildlife, Wildlife Health Program, 4330 Laporte Ave., Fort Collins, Colorado 80521, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha E.","family":"Allen","sequence":"additional","affiliation":[{"name":"Wyoming Game and Fish Department, Veterinary Services, 1212 S. Adams St., Laramie, Wyoming 82070, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Colorado Parks and Wildlife, Wildlife Health Program, 4330 Laporte Ave., Fort Collins, Colorado 80521, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4415","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"TE Besser, MA Highland, K Baker, et al.  \"Emerg Infect Dis.\"  18, \"Causes of pneumonia epizootics among bighorn sheep, western United States, 2008\u20132010.\" 406 (2012)","DOI":"10.3201\/eid1803.111554"},{"key":"18","doi-asserted-by":"crossref","unstructured":"DP Walsh, EF Cassirer, MD Bonds, et al.  \"Wildl Soc Bull.\"  40, \"Concordance in diagnostic testing for respiratory pathogens of bighorn sheep.\" 634 (2016)","DOI":"10.1002\/wsb.721"},{"key":"20","doi-asserted-by":"crossref","unstructured":"GC Weiser, DS Miller, ML Drew, et al.  \"J Zoo Wildl Med.\"  40, 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(2019)","DOI":"10.1016\/j.smallrumres.2019.05.005"},{"key":"15","doi-asserted-by":"crossref","unstructured":"DH Shaw  and SI Rubin  \"J Am Vet Med Assoc.\"  189, \"Pharmacologic activity of doxycycline.\" 808 (1986)","DOI":"10.2460\/javma.1986.189.07.808"},{"key":"17","doi-asserted-by":"crossref","unstructured":"E Turk, O Corum, IO Tekeli, et al.  \"Animals.\"  10, \"Effects of single and repeated doses on disposition and kinetics of doxycycline hyclate in goats.\" 1088 (2020)","DOI":"10.3390\/ani10061088"},{"key":"19","doi-asserted-by":"crossref","unstructured":"GC Weiser, ML Drew, EF Cassirer, et al.  \"J Wildl Dis.\"  48, \"Detection of Mycoplasma ovipneumoniae and M. arginini in bighorn sheep using enrichment culture coupled with genus- and species-specific polymerase chain reaction.\" 449 (2012)","DOI":"10.7589\/0090-3558-48.2.449"},{"key":"21","doi-asserted-by":"crossref","unstructured":"ME Wood, KA Fox, J Jennings-Gaines, et al.  \"J Wildl Dis.\"  53, \"How respiratory pathogens contribute to lamb mortality in a poorly performing bighorn sheep (Ovis canadensis) herd.\" 126 (2017)","DOI":"10.7589\/2016-05-097"},{"key":"22","doi-asserted-by":"crossref","unstructured":"MI Yatoo, OR Parray, RA Bhat, et al.  \"J Pure Appl Microbiol.\"  13, \"Emerging antibiotic resistance in Mycoplasma microorganisms, designing effective and novel drugs\/therapeutic targets: Current knowledge and futuristic prospects.\" 27 (2019)","DOI":"10.22207\/JPAM.13.1.03"}],"container-title":["Journal of Wildlife Diseases"],"original-title":[],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:13:00Z","timestamp":1793423580000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/journal-of-wildlife-diseases\/volume-59\/issue-4\/JWD-D-22-00094\/Clearance-of-Mycoplasma-ovipneumoniae-in-Captive-Bighorn-Sheep-Ovis-canadensis\/10.7589\/JWD-D-22-00094.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,24]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,10,1]]}},"URL":"https:\/\/doi.org\/10.7589\/jwd-d-22-00094","relation":{},"ISSN":["0090-3558","1943-3700"],"issn-type":[{"value":"0090-3558","type":"print"},{"value":"1943-3700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,24]]}}}