{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:13:54Z","timestamp":1793661234750,"version":"4.5.1"},"reference-count":26,"publisher":"Wildlife Disease Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Wildlife Diseases"],"published-print":{"date-parts":[[2025,5,16]]},"abstract":"<jats:p>Leptospirosis is a complex and often underestimated global bacterial disease that continues to be of zoonotic concern. It is difficult to diagnose and has an unclear pathogenesis. Several new species of the genus Leptospira have been discovered in recent years; the impact of these species on animal health is unknown. In 2013, Leptospira tipperaryensis was first identified in greater white-toothed shrews (GWTSs, Crocidura russula) in Ireland, where they are an invasive species that displaces the native pygmy shrew (Sorex minutus). This study investigated the prevalence of Leptospira spp., including L. tipperaryensis, and their potential impact on the health of shrews from Ireland using histopathology (n=212), immunohistochemistry (IHC; n=206), and quantitative PCR (n=168) on renal tissues. Shrews (n=81) from Belle \u00cele, France were examined as a species and habitat control group using histopathology (n=81) and IHC (n=79). No Leptospira were detected with any of the methods in renal tissues from shrews sampled in Ireland and there was no significant renal pathology. In contrast, 34.6% (28\/81) of shrews from Belle \u00cele were positive on IHC for Leptospira sp. and had associated chronic nephritis in histopathology. The results do not indicate a negative impact by L. tipperaryensis or other Leptospira spp. on the health and distribution of the GWTS and the pygmy shrew in Ireland; onward transmission within the shrew population currently appears unlikely.<\/jats:p>","DOI":"10.7589\/jwd-d-24-00084","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:24:57Z","timestamp":1747355097000},"page":"477-482","source":"Crossref","is-referenced-by-count":5,"title":["Surveillance for Leptospira sp. in Native and Invasive Shrews in Ireland Compared with Cohabitating Shrews in France"],"prefix":"10.7589","volume":"61","author":[{"given":"Michelle","family":"Imlau","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University College Dublin, Veterinary Sciences Centre, Dublin, D04 W6F6, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Browne","sequence":"additional","affiliation":[{"name":"School of Agriculture & Food Science, University College Dublin, Agriculture and Food Science Centre, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Browett","sequence":"additional","affiliation":[{"name":"Molecular Ecology Research Group, Eco-Innovation Research Centre, School of Science and Computing, South East Technological University, Cork Road, Waterford, X91 K0EK, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan D.","family":"McDevitt","sequence":"additional","affiliation":[{"name":"Marine and Freshwater Research Centre, Department of Natural Resources and the Environment, Atlantic Technological University, Dublin Road, Galway, H91 T8NW, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry J.","family":"McMahon","sequence":"additional","affiliation":[{"name":"School of Agriculture & Food Science, University College Dublin, Agriculture and Food Science Centre, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarlath E.","family":"Nally","sequence":"additional","affiliation":[{"name":"Infectious Bacterial Diseases Research Unit, Agricultural Research Service, US Department of Agriculture, 1920 Dayton Avenue, Ames, Iowa 50010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Jahns","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University College Dublin, Veterinary Sciences Centre, Dublin, D04 W6F6, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4415","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"B Adler  and MA de la Pe\u00f1a  \"Vet Microbiol.\"  140, \"Leptospira and leptospirosis.\" 287 (2010)","DOI":"10.1016\/j.vetmic.2009.03.012"},{"key":"2","doi-asserted-by":"crossref","unstructured":"P Agudelo-Fl\u00f3rez, VE Murillo, AF Londo\u00f1o, et al.  \"Biomedica.\"  33, \"Histopathological kidney alterations in rats naturally infected with Leptospira.\" 82 (2013)","DOI":"10.7705\/biomedica.v33i0.686"},{"key":"3","doi-asserted-by":"crossref","unstructured":"AA Ahmed, MGA Goris, MC Meijer,  \"PLoS One.\"  15, \"Development of lipL32 real-time PCR combined with an internal and extraction control for pathogenic Leptospira detection.\" e0241584 (2020)","DOI":"10.1371\/journal.pone.0241584"},{"key":"4","unstructured":"NM. 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Diseases"],"original-title":[],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:17:01Z","timestamp":1791242221000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/journal-of-wildlife-diseases\/volume-61\/issue-2\/JWD-D-24-00084\/Surveillance-for-Leptospira-sp-in-Native-and-Invasive-Shrews-in\/10.7589\/JWD-D-24-00084.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.7589\/jwd-d-24-00084","relation":{},"ISSN":["0090-3558","1943-3700"],"issn-type":[{"value":"0090-3558","type":"print"},{"value":"1943-3700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]}}}