{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:53:59Z","timestamp":1783529639320,"version":"3.55.0"},"reference-count":30,"publisher":"Korean College of Helicobacter and Upper Gastrointestinal Research","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"IL-YANG Pharmaceutical Co., Ltd."}],"content-domain":{"domain":["helicojournal.org"],"crossmark-restriction":true},"short-container-title":["Korean J Helicobacter Up Gastrointest Res"],"published-print":{"date-parts":[[2025,9,10]]},"abstract":"<jats:p>Objectives: &lt;i&gt;Helicobacter pylori&lt;\/i&gt; eradication treatment typically occurs after gastrectomy; however, the specific criteria for eradication treatment have not been reported. This study aimed to evaluate the rates and locations of spontaneous clearance, as well as the accompanying histological changes. Methods: Patients with &lt;i&gt;H. pylori&lt;\/i&gt;-positive status at the time of gastric cancer diagnosis and who underwent subtotal gastrectomy at a tertiary care center in Seoul (South Korea) were prospectively enrolled in this study. &lt;i&gt;H. pylori&lt;\/i&gt; infection status and histological features (presence of mononuclear cells, neutrophils, atrophy, and intestinal metaplasia) were evaluated pre- and postoperatively at different locations in the stomach. Results: Sixteen patients with &lt;i&gt;H. pylori&lt;\/i&gt;-positive gastric cancer underwent subtotal gastrectomy. Of these, 13 (81.3%) showed spontaneous clearance at least once during the follow-up. Half of the patients (8, 50.0%) had cleared their infections within 6 months after surgery. Histological factors, such as neutrophil and mononuclear cell counts, atrophy, and intestinal metaplasia, did not differ according to &lt;i&gt;H. pylori&lt;\/i&gt; clearance status. The spontaneous clearance rates of &lt;i&gt;H. pylori&lt;\/i&gt; were 69.2% in the cardia, 46.1% in the fundus, 38.4% in the lesser curvature of the mid-body, and 41.6% in the greater curvature of the mid-body; the differences in clearance rates were not significant (&lt;i&gt;p&lt;\/i&gt;=0.149). Conclusions: The rate of spontaneous &lt;i&gt;H. pylori&lt;\/i&gt; clearance was high in patients with gastric cancer who underwent subtotal gastrectomy. Postoperative &lt;i&gt;H. pylori&lt;\/i&gt; status should be re-evaluated to confirm the presence of infection prior to considering eradicating therapy.<\/jats:p>","DOI":"10.7704\/kjhugr.2025.0029","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T01:15:46Z","timestamp":1756775746000},"page":"268-275","update-policy":"https:\/\/doi.org\/10.7704\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characteristics Associated With Spontaneous Helicobacter pylori Clearance After Subtotal Gastrectomy in Patients With Gastric Cancer"],"prefix":"10.7704","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8237-8894","authenticated-orcid":true,"given":"So Young","family":"Byun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2351-4402","authenticated-orcid":true,"given":"Hee 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