{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:11:04Z","timestamp":1789582264423,"version":"build-2803163510"},"reference-count":23,"publisher":"Korean College of Helicobacter and Upper Gastrointestinal Research","issue":"3","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","award":["2510850"],"award-info":[{"award-number":["2510850"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["helicojournal.org"],"crossmark-restriction":true},"short-container-title":["Korean J Helicobacter Up Gastrointest Res"],"published-print":{"date-parts":[[2026,9,10]]},"abstract":"Objectives: The annual incidence of new <i>Helicobacter pylori<\/i> infections evaluated by serological test in Korean adults has been reported to be 2.1%\u20133.3%. This study evaluated the rate of new <i>H. pylori<\/i> infections using the urea breath test (UBT) and the factors associated with new infection.Methods: In this prospective observational study, we recruited participants from the National Cancer Screening Program who tested negative for <i>H. pylori<\/i> infection by both rapid urease test and histology between November 2007 and December 2014. The participants underwent the UBT to check their follow-up <i>H. pylori<\/i> infection status from August 2015 to December 2017. The primary outcome of this study was new <i>H. pylori<\/i> infection.Results: A total of 192 participants were enrolled in this study. During the mean follow-up of 4.1 years from the initial negative tests for <i>H. pylori<\/i> infection, a new infection occurred in six participants (3.1%, 6\/192 participants). According to analyses using the logistic regression model, age (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.02\u20131.26) and corpus atrophy (OR, 9.83; 95% CI, 1.59\u201360.98) were associated with the new <i>H. pylori<\/i> infection in univariate analyses. However, no significant factors were identified in multivariate analysis.Conclusions: New <i>H. pylori<\/i> infection rarely occurred in Korean adults, with a rate of 3.1%. However, no independent risk factors for new infection were identified.<\/jats:p>","DOI":"10.7704\/kjhugr.2026.0004","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:34:11Z","timestamp":1788914051000},"page":"300-306","update-policy":"https:\/\/doi.org\/10.7704\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Occurrence of New Helicobacter pylori Infections in Healthy, Helicobacter pylori-Negative Adults: A Prospective Observational Study"],"prefix":"10.7704","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-3419","authenticated-orcid":true,"given":"Young-Il","family":"Kim","sequence":"first","affiliation":[{"name":"Center for Gastric Cancer, National Cancer Center, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3435-3301","authenticated-orcid":true,"given":"Myeong-Cherl","family":"Kook","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer, National Cancer Center, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8709-5097","authenticated-orcid":true,"given":"Jong Yeul","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer, National Cancer Center, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-2559","authenticated-orcid":true,"given":"Chan Gyoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer, National Cancer Center, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8339-9824","authenticated-orcid":true,"given":"Il Ju","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer, National Cancer Center, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4435","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp1710945","type":"journal-article"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022","type":"journal-article"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204762","type":"journal-article"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7704\/kjhugr.2022.0022","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra020542","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91782-y","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-8553(05)70130-8","type":"journal-article"},{"key":"ref8","first-page":"45","type":"journal-article","volume-title":"The incidence of Helicobacter pylori infection","author":"Parsonnet","year":"1995"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.50043.x","type":"journal-article"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510015917","type":"journal-article"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12043","type":"journal-article"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2020.299","type":"journal-article"},{"key":"ref13","first-page":"1161","type":"journal-article","volume-title":"Classification and grading of gastritis. 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