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Sus usos potenciales abarcan, entre otros, el diagn\u00f3stico de enfermedades, el desarrollo de nuevos agentes terap\u00e9uticos, la detecci\u00f3n de riesgos alimentarios, la producci\u00f3n de biosensores, la detecci\u00f3n de toxinas, el transporte de f\u00e1rmacos en el organismo y la se\u00f1alizaci\u00f3n de nanopart\u00edculas.El pegaptanib es el \u00fanico apt\u00e1mero aprobado para uso comercial por la Food and Drug Administration (FDA).\u00a0En parasitolog\u00eda, se destacan los estudios que se vienen realizando en Leishmania spp., con la obtenci\u00f3n de apt\u00e1meros que reconocen la prote\u00edna de uni\u00f3n a poliA (LiPABP) y que pueden tener potencial utilidad en la investigaci\u00f3n, el diagn\u00f3stico y el tratamiento de la leishmaniasis. En cuanto a la malaria, se han obtenido apt\u00e1meros que permiten identificar eritrocitos infectados e inhiben la formaci\u00f3n de rosetas, y otros que prometen ser alternativas para el diagn\u00f3stico al detectar de forma espec\u00edfica la prote\u00edna lactato deshidrogenasa (PfLDH). Para Cryptosporidium parvuum se han seleccionado apt\u00e1meros que detectan ooquistes a partir de alimentos o aguas contaminadas. Para Entamoeba histolytica se han aislado dos apt\u00e1meros llamados C4 y C5, que inhiben la proliferaci\u00f3n in vitro de los trofozo\u00edtos y tienen potencial terap\u00e9utico. Los apt\u00e1meros contra Trypanosoma cruzi inhiben la invasi\u00f3n de c\u00e9lulas LLC-MK2 (de ri\u00f1\u00f3n de mono) en un 50 a 70 % y aquellos contra T. brucei transportan mol\u00e9culas t\u00f3xicas al lisosoma parasitario como una novedosa estrategia terap\u00e9utica.<\/jats:p>","DOI":"10.7705\/biomedica.4765","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T21:32:34Z","timestamp":1590615154000},"page":"148-165","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Los apt\u00e1meros como novedosa herramienta diagn\u00f3stica y terap\u00e9utica y su potencial uso en parasitolog\u00eda"],"prefix":"10.7705","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1679-3036","authenticated-orcid":false,"given":"Juan David","family":"Ospina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"97948","unstructured":"Shannon-Pendergrast P, Nicholas-Marsh H, Grate D, Healy JM, Stanton M. 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