{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T22:58:07Z","timestamp":1772060287348,"version":"3.50.1"},"reference-count":25,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"1","content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["biomedica"],"abstract":"<jats:p>Envenomations by colubrid snakes in Colombia are poorly known, consequently, the clinical relevance of these species in snakebite accidents has been historically underestimated. Herein, we report the first case of envenomation by opisthoglyphous snakes in Colombia occurred under fieldwork conditions at the municipality of Distracci\u00f3n, in the department of La Guajira. A female biologist was bitten on the index finger knuckle of her right hand when she tried to handle a false fer-de-lance snake (Leptodeira annulata). Ten minutes after the snakebite, the patient started to have symptoms of mild local envenomation such as edema, itching, and pain in the wound. After 40 minutes, the edema reached its maximum extension covering the dorsal surface of the right hand and causing complete loss of mobility. The clinical treatment focused on pain and swelling control. No laboratory tests were performed. The patient showed good progress with the total regression of the edema 120 hours after the snake-bite accident and complete recovery of the movement of the limb in one week. Venomous bites of \u201cnon-venomous snakes\u201d (opisthoglyphous colubrid snakes) must be considered as a significant public health problem because patients lose their work capability during hours or even days and they are forced to seek medical assistance to treat the envenomation manifestations.<\/jats:p>","DOI":"10.7705\/biomedica.4773","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T15:56:37Z","timestamp":1584633397000},"page":"20-26","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":11,"title":["A case of envenomation by the false fer-de-lance snake Leptodeira annulata (Linnaeus, 1758) in the department of La Guajira, Colombia"],"prefix":"10.7705","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5978-9312","authenticated-orcid":false,"given":"Teddy","family":"Angarita-Sierra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Monta\u00f1ez-M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Toro-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariadna","family":"Rodr\u00edguez-Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2020,3,1]]},"reference":[{"key":"ref0","unstructured":"Instituto Nacional de Salud. Informe del evento accidente of\u00eddico, Colombia, 2016. Bogot\u00e1: Instituto Nacional de Salud; 2016."},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Chippaux JP. Incidence and mortality due to snakebite in the Americas. PLoS Negl Trop Dis. 2017;11:e0005662. https:\/\/doi.org\/10.1371\/journal.pntd.0005662","DOI":"10.1371\/journal.pntd.0005662"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Otero-Pati\u00f1o R. Snakebites in Colombia. In: Gopalakrishnakone P, Vogel CW, Seifert S, Tambourgi D, editors. Clinical toxicology in Australia, Europe, and the Americas. Toxinology. Dordrecht: Springer; 2018. p. 3-50. https:\/\/doi.org\/10.1007\/978-94-017-7438-3_41","DOI":"10.1007\/978-94-017-7438-3_41"},{"key":"ref3","unstructured":"Weinstein SA, Warrell DA, White J, Keyler DE. Venomous bites from non-venomous snakes: A critical analysis of risk and management of colubrid snake bites. First edition. Burlington, MA: Elsevier Ltd; 2011. p. 364."},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Lynch JD. El contexto de las serpientes de Colombia con un an\u00e1lisis de las amenazas en contra de su conservaci\u00f3n. Revista de la Academia Colombiana de Ciencias Exactas, F\u00edsicas y Naturales. 2012;36:435-49.","DOI":"10.18257\/raccefyn.36(140).2012.2495"},{"key":"ref5","unstructured":"Lynch JD, Angarita-Sierra T, Ruiz FJ. Programa Nacional para la Conservaci\u00f3n de las Serpientes Presentes en Colombia. Bogot\u00e1: Ministerio de Ambiente y Desarrollo Sostenible, Universidad Nacional de Colombia, Instituto Nacional de Salud; 2014. p. 128."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"de Ara\u00fajo PF, da Silva WM, de Fran\u00e7a RC, Fran\u00e7a FG. A case of envenomation by Neotropical opisthoglyphous snake Thamnodynastes pallidus (Linnaeus, 1758) (Colubridae: Dipsadinae: Tachymenini) in Brazil. Rev Inst Med Trop Sao Paulo. 2018;60:11-4. https:\/\/doi.org\/10.1590\/s1678-9946201860038","DOI":"10.1590\/s1678-9946201860038"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Daza JM, Smith EN, P\u00e1ez VP, Parkinson CL. Complex evolution in the Neotropics: The origin and diversification of the widespread genus Leptodeira (Serpentes: Colubridae). Mol Phylogenet Evol. 2009;53:653-67. https:\/\/doi.org\/10.1016\/j.ympev.2009.07.022","DOI":"10.1016\/j.ympev.2009.07.022"},{"key":"ref8","unstructured":"Mendoza I. Defensive behavior in Leptodeira annulata ashmeadii (Hallowell, 1845). Herpetotropicos. 2008;5:67."},{"key":"ref9","unstructured":"Duellman WE. A monographic study of the colubrid snake genus Leptodeira. Bull Am Museum Nat Hist. 1958;114:1-152."},{"key":"ref10","unstructured":"Gorzula S. Leptodeira annulata ashmedeadii envenomation. SSAR Herpetological Review. 1982;13:47."},{"key":"ref11","unstructured":"Warrell DA. Epidemiology, clinical features, and clinical management. In: Campbell JA, Lamar WW, editors. The venomous reptiles of the Western Hemisphere. First edition. Ithaca: Cornell Press; 2004. p. 709-61."},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Torres-Bonilla KA, Schezaro-Ramos R, Floriano RS, Rodrigues-Simioni L, Bernal-Bautista MH, Alice da Cruz-H\u00f6fling M. Biological activities of Leptodeira annulata (banded cat-eyed snake) venom on vertebrate neuromuscular preparations. Toxicon. 2016;119:345-51. https:\/\/doi.org\/10.1016\/j.toxicon.2016.07.004","DOI":"10.1016\/j.toxicon.2016.07.004"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"de Medeiros CR, Hess P, Nicoleti AF, Sueiro LR, Duarte MR, de Almeida-Santos S, et al. Bites by the colubrid snake Philodryas patagoniensis: A clinical and epidemiological study of 297 cases. Toxicon. 2010;56:101-24. https:\/\/doi.org\/10.1016\/j.toxicon.2010.07.006","DOI":"10.1016\/j.toxicon.2010.07.006"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Prado-Franceschi J, Hyslop, S. South American colubrid envenomation. J Toxicol. 2002;21:117-58. https:\/\/doi.org\/10.1081\/TXR-120004744","DOI":"10.1081\/TXR-120004744"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Weinstein SA, Griffin R, Ismail AK. Non-front-fanged colubroid (\"colubrid\") snakebites: Three cases of local envenoming by the mangrove or ringed cat-eyed snake (Boiga dendrophila; Colubridae, Colubrinae), the Western beaked snake (Rhamphiophis oxyrhynchus; Lamprophiidae, Psammophinae) and the rain forest cat-eyed snake (Leptodeira frenata; Dipsadidae). Clin Toxicol (Phila). 2014;52:277-82. https:\/\/doi.org\/10.3109\/15563650.2014.897352","DOI":"10.3109\/15563650.2014.897352"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Nelwan EJ, Adiwinata R, Handayani S, Rinaldi I. Severe coagulophaty and transient hypertension following Rhabdophis subminiatus bite. Rev Soc Bras Med Trop. 2016;49:520-2. https:\/\/doi.org\/10.1590\/0037-8682-0314-2015","DOI":"10.1590\/0037-8682-0314-2015"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Weinstein S, White J, Keyler D, Warrell D. Non-front-fanged colubrois snakes: A current evidence-based analyses of medical significance. Toxicon. 2013;69:103-13. https:\/\/doi.org\/10.1016\/j.toxicon.2013.02.003","DOI":"10.1016\/j.toxicon.2013.02.003"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Pham HX, Mullins ME. Safety of nonsteroidal anti-inflammatory drugs in copperhead snakebite patients. Clin Toxicol (Phila). 2018;56:1121-7. https:\/\/doi.org\/10.1080\/15563650.2018.1468447","DOI":"10.1080\/15563650.2018.1468447"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Diaz F, Navarrete LF, Pefaur J, Rodr\u00edguez-Acosta A. Envenomation by neotropical opistoglyphous colubrid Thamnodynastes cf. pallidus Linn\u00e9, 1758 (Serpentes: Colubridae) in Venezuela. Rev Inst Med Trop Sao Paulo. 2004;46:287-90. https:\/\/doi.org\/10.1590\/S0036-46652004000500011","DOI":"10.1590\/S0036-46652004000500011"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"August JA, Boesen KJ, Shirazi FM, Klotz SA. Prophylactic antibiotics are not needed following rattlesnake bites. Am J Med. 2018;131:1367-71. https:\/\/doi.org\/10.1016\/j.amjmed.2018.06.006","DOI":"10.1016\/j.amjmed.2018.06.006"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Gillet Y, Lorrot M, Cohen R, Hau I, Grimprel E., Gras-Le Guen C. Antibioth\u00e9rapie des infections cutan\u00e9es. Arch Pediatr. 2017;24: S26-31.","DOI":"10.1016\/S0929-693X(17)30516-X"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/beheco\/arh024","article-title":"Size-based variation in antipredator behavior within a snake (Agkistrodon piscivorus) population","volume":"15","author":"ED","year":"2004","unstructured":"Roth ED, Johnson JA. Size-based variation in antipredator behavior within a snake (Agkistrodon piscivorus) population. Behav Ecol. 2004;15:365-70.","journal-title":"Behav Ecol"},{"key":"ref23","unstructured":"Angarita-Sierra T. Repertoire of antipredator displays in the semifossorial snake Ninia atrata (Hallowell, 1845). Herpetol Notes. 2015;8:339-44."},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Instituto Nacional de Salud. Informe evento accidente of\u00eddico, periodo epidemiol\u00f3gico VIII Colombia, 2018. Bogot\u00e1; INS; 2018. Accessed on: July 23, 2018. 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