{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:06:22Z","timestamp":1793639182822,"version":"4.5.1"},"reference-count":39,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"2","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["biomedica"],"abstract":"<jats:p>Introducci\u00f3n. La obesidad se considera un grave problema de salud p\u00fablica y por ello se hacen esfuerzos en la b\u00fasqueda de genes como el LEP, el LEPR y el MC4R del sistema leptina-melanocortina, el cual opera en la regulaci\u00f3n neuroendocrina de la ingesti\u00f3n y el equilibrio energ\u00e9tico e influye en la patogenia de la enfermedad. Los resultados contradictorios en torno a la asociaci\u00f3n de estos genes con la obesidad plantean la necesidad de nuevas investigaciones.Objetivo. Analizar los polimorfismos rs2167270 del gen LEP, rs1137101 del gen LEPR y rs17782313 del gen MC4R asociados con la obesidad y sus variables cl\u00ednicas y bioqu\u00edmicas en una muestra de pacientes adultos de Barranquilla.Materiales y m\u00e9todos. Se estudiaron 111 personas obesas y 155 no obesas como controles. Los polimorfismos se determinaron mediante reacci\u00f3n en cadena de la polimerasa (PCR) en tiempo real. Se tomaron las medidas antropom\u00e9tricas, se evalu\u00f3 la presi\u00f3n arterial y se hicieron pruebas bioqu\u00edmicas.Resultados. No se encontraron diferencias estad\u00edsticas en la frecuencia al\u00e9lica y genot\u00edpica de los polimorfismos en los grupos estudiados. En cuanto a las variables cl\u00ednicas y bioqu\u00edmicas, el genotipo CC del polimorfismo rs17782313 del gen MC4R, se asoci\u00f3 con un aumento de la presi\u00f3n arterial sist\u00f3lica y, el alelo T y su genotipo homocigoto, con una disminuci\u00f3n del colesterol HDL en los obesos. No se evidenci\u00f3 ning\u00fan efecto de los otros polimorfismos en estas variables.Conclusiones. Los polimorfismos rs2167270 del gen LEP, rs1137101 del gen LEPR y rs17782313 del gen MC4R, no se asociaron con obesidad en la poblaci\u00f3n analizada. Se encontr\u00f3 que el polimorfismo rs17782313 del gen MC4R influy\u00f3 en el aumento de la presi\u00f3n arterial sist\u00f3lica y la disminuci\u00f3n del colesterol HDL en las personas obesas.<\/jats:p>","DOI":"10.7705\/biomedica.4827","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T15:00:07Z","timestamp":1594738807000},"page":"257-269","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Polimorfismos de los genes del sistema leptina-melanocortina asociados con la obesidad en la poblaci\u00f3n adulta de Barranquilla"],"prefix":"10.7705","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-3399","authenticated-orcid":false,"given":"Pilar","family":"Garavito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9662-2925","authenticated-orcid":false,"given":"Mar\u00eda Isabel","family":"Mosquera-Heredia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4986-6118","authenticated-orcid":false,"given":"Luis","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2682-5505","authenticated-orcid":false,"given":"Fausto","family":"Payares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6793-7197","authenticated-orcid":false,"given":"Martha","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2188-9542","authenticated-orcid":false,"given":"Isis","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-7199","authenticated-orcid":false,"given":"Rafael","family":"Tuesca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3181-2891","authenticated-orcid":false,"given":"\u00c9dgar","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9506-1863","authenticated-orcid":false,"given":"Carlos","family":"Silvera-Redondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"98619","unstructured":"Organizaci\u00f3n Mundial de La Salud. 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