{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:43:21Z","timestamp":1792248201564,"version":"4.4.0"},"reference-count":55,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"Supl. 1","content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["biomedica"],"abstract":"<jats:p>Introducci\u00f3n. El virus de Epstein-Barr (EBV) es un virus ubicuo y oncog\u00e9nico, asociado con el desarrollo de enfermedades como la mononucleosis infecciosa, el linfoma de Burkitt, el carcinoma nasofar\u00edngeo y otras neoplasias. Actualmente, se reconocen dos subtipos: EBV-1 y EBV- 2, que tienen diferencias gen\u00e9ticas con sus ant\u00edgenos nucleares (Epstein-Barr Nuclear Antigens, EBNA). Debido a la gran heterogeneidad y variabilidad encontradas en la prote\u00edna LMP1 del virus, se han descrito variantes asociadas con ciertas enfermedades o con regiones geogr\u00e1ficas espec\u00edficas.Objetivo. Identificar y caracterizar molecularmente las variantes del EBV detectadas en la cavidad oral de 84 adolescentes de Cali, Colombia.Materiales y m\u00e9todos. Se hizo la amplificaci\u00f3n por reacci\u00f3n en cadena de la polimerasa (Polymerase Chain Reaction, PCR) convencional, as\u00ed como la purificaci\u00f3n y la secuenciaci\u00f3n del gen EBNA3C se realiz\u00f3 para subtipificar el virus y del dominio C-ter de la prote\u00edna LMP1 para identificar variantes. Adem\u00e1s, se llev\u00f3 a cabo un an\u00e1lisis filogen\u00e9tico y de variantes nucleot\u00eddicas de las secuencias obtenidas comparadas con variantes patog\u00e9nicas y geogr\u00e1ficas reportadas en el GenBank (National Center for Biotechnology Information, NCBI).Resultados. El subtipo viral predominante fue el EBV-1 (79 %); el 72,6 % se agrup\u00f3 con la variante patog\u00e9nica Raji, derivada de linfocitos B de un paciente con linfoma de Burkitt; el 13,7 % se relacion\u00f3 con una variante de origen geogr\u00e1fico del Mediterr\u00e1neo y otro 13,7 % no se agrup\u00f3 con ninguna de las variantes de referencia.Conclusiones. Este es el primer estudio que reporta variantes del gen LMP1-EBV en Cali, Colombia. Se requieren nuevos estudios para caracterizar la variante sin identificar y determinar si es patog\u00e9nica o si es una variante geogr\u00e1fica presente exclusivamente en la ciudad.<\/jats:p>","DOI":"10.7705\/biomedica.4917","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T21:32:34Z","timestamp":1590615154000},"page":"76-88","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Caracterizaci\u00f3n molecular de las variantes del virus de Epstein-Barr detectadas en la cavidad oral de adolescentes de Cali, Colombia"],"prefix":"10.7705","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5914-0601","authenticated-orcid":false,"given":"Daniela","family":"Arturo-Terranova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Giraldo-Ocampo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"97634","doi-asserted-by":"crossref","unstructured":"Epstein MA, Achong BG, Barr YM. 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