{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:55:36Z","timestamp":1782856536203,"version":"3.54.5"},"reference-count":44,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"4","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["biomedica"],"abstract":"<jats:p>Introducci\u00f3n. No se dispone de pruebas sensibles ni espec\u00edficas para diagnosticar la artritis idiop\u00e1tica juvenil sist\u00e9mica.Objetivo. Evaluar la utilidad diagn\u00f3stica de niveles de ferritina total cinco veces por encima del valor normal (ferritina total&gt;5N) y el porcentaje disminuido (menor de o igual a 20 % de la ferritina total) de la ferritina glucosilada (ferritina glucosilada&lt;20 %) para el diagn\u00f3stico de artritis idiop\u00e1tica juvenil sist\u00e9mica en pacientes con fiebre de origen desconocido evaluados por reumatolog\u00eda pedi\u00e1trica.Materiales y m\u00e9todos. Se hizo un estudio observacional de pruebas diagn\u00f3sticas de corte transversal en menores de 16 a\u00f1os hospitalizados entre el 2010 y el 2014. El patr\u00f3n diagn\u00f3stico de referencia fue el cumplimiento de los criterios de clasificaci\u00f3n o diagn\u00f3stico confirmado en el seguimiento. Se determinaron las medidas de utilidad de las pruebas.Resultados. Se incluyeron 40 pacientes con fiebre de origen desconocido: 11 con artritis idiop\u00e1tica juvenil sist\u00e9mica y 29 con otros diagn\u00f3sticos. La mediana de la ferritina total fue mayor en la artritis idiop\u00e1tica juvenil sist\u00e9mica (3.992 ng\/ml) comparada con otras causas de fiebre de origen desconocido (155 ng\/ml) (p=0,0027), as\u00ed como la ferritina total&gt;5N (90,91 % Vs. 51,72 %) (p=0,023). El porcentaje de ferritina glucosilada\u226420 % fue de 96,5 % en otras fiebres de origen desconocido en comparaci\u00f3n con la artritis idiop\u00e1tica juvenil sist\u00e9mica (81,8 %) (p=0,178). La ferritina total&gt;5N tuvo una sensibilidad del 91 %, una especificidad del 48 %; un cociente de probabilidades (Likelihood Ratio, LR) positivo de 1,76 y uno negativo de 0,19, demostrando mayor utilidad para el diagn\u00f3stico que la combinaci\u00f3n de la ferritina total&gt;5N y ferritina glucosilada\u226420 %, cuya sensibilidad fue del 81,8 %, la especificidad del 48,3 %, un cociente de probabilidades LR positivo de 1,58 y un LR negativo de 0,38.Conclusi\u00f3n. En pacientes con fiebre de origen desconocido evaluados por reumatolog\u00eda pedi\u00e1trica, la ferritina total&gt;5N demostr\u00f3 ser \u00fatil como prueba de tamizaci\u00f3n para el diagn\u00f3stico de artritis idiop\u00e1tica juvenil sist\u00e9mica.<\/jats:p>","DOI":"10.7705\/biomedica.5849","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T13:18:12Z","timestamp":1630588692000},"page":"787-802","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Niveles de ferritina en artritis idiop\u00e1tica juvenil de inicio sist\u00e9mico comparada con otras fiebres de origen desconocido: estudio multic\u00e9ntrico de pruebas diagn\u00f3sticas"],"prefix":"10.7705","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2135-2382","authenticated-orcid":false,"given":"Ruth","family":"Eraso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-8602","authenticated-orcid":false,"given":"Claudia Patricia","family":"Ben\u00edtez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Jaramillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4303-3243","authenticated-orcid":false,"given":"Jorge","family":"Acosta-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-8602","authenticated-orcid":false,"given":"Beatriz Helena","family":"Aristiz\u00e1bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-8236","authenticated-orcid":false,"given":"Augusto","family":"Quevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"107111","doi-asserted-by":"crossref","unstructured":"Lee JJY, Schneider R. 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