{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:10:13Z","timestamp":1789467013807,"version":"build-2803163510"},"reference-count":12,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"4","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["biomedica"],"abstract":"<jats:p>Hay pocos reportes de enfermedad hemol\u00edtica del feto y del reci\u00e9n nacido causada por aloanticuerpos contra el sistema de ant\u00edgenos MNS, especialmente, porque los anticuerpos que se generan contra estos ant\u00edgenos son del tipo IgM, los cuales tienen reactividad a temperaturas inferiores a los 37 \u00b0C, y, por lo tanto, no son de importancia cl\u00ednica. A pesar de ello, se han reportado casos con presencia de anticuerpos anti-M de tipo IgG causantes de la enfermedad hemol\u00edtica del reci\u00e9n nacido e, incluso, casos de muerte intrauterina por incompatibilidad materno-fetal en el sistema MNS. El proceso hemol\u00edtico se asemeja al causado por los anticuerpos anti-Kell, con anemia progresiva por supresi\u00f3n hematopoy\u00e9tica que induce la destrucci\u00f3n de precursores hematopoy\u00e9ticos en la m\u00e9dula \u00f3sea y ausencia de reticulocitos en la periferia.Se reporta el caso de una mujer con 38,5 semanas de gestaci\u00f3n, que present\u00f3 discrepancia en la hemoclasificaci\u00f3n directa y en la inversa. Como resultado, el reci\u00e9n nacido fue positivo en la prueba de Coombs directa sin que existiera incompatibilidad ABO con la madre. La correlaci\u00f3n de estos resultados llev\u00f3 a la detecci\u00f3n de un anticuerpo anti-M en el suero materno. El diagn\u00f3stico definitivo fue posible gracias a la discrepancia en la hemoclasificaci\u00f3n de la sangre materna. A pesar de que los anticuerpos anti-M usualmente no desempe\u00f1an un papel importante en la enfermedad hemol\u00edtica perinatal, este caso resalta la importancia de determinar la presencia de diferentes anticuerpos que pueden ser de inter\u00e9s a la hora de prevenir resultados graves asociados con dicha condici\u00f3n.<\/jats:p>","DOI":"10.7705\/biomedica.5930","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T13:18:12Z","timestamp":1630588692000},"page":"643-650","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Enfermedad hemol\u00edtica del feto y del reci\u00e9n nacido por aloanticuerpos contra el ant\u00edgeno M"],"prefix":"10.7705","volume":"41","author":[{"given":"Marco","family":"P\u00e1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3075-9854","authenticated-orcid":false,"given":"Mar\u00eda","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-367X","authenticated-orcid":false,"given":"Ana","family":"Corredor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"106633","doi-asserted-by":"crossref","unstructured":"Philip J, Kushwaha N, Jain N. Report of two cases of anti-M antibody in antenatal patients. Asian J Transfus Sci. 2015;9:89-91. https:\/\/doi.org\/10.4103\/0973-6247.150963","DOI":"10.4103\/0973-6247.150963"},{"key":"106634","doi-asserted-by":"crossref","unstructured":"Heathcote DJ, Carroll TE, Flower RL. Sixty years of antibodies to MNS system hybrid glycophorins: What have we learned? Transfus Med Rev. 2011;25:111-24. https:\/\/doi.org\/10.1016\/j.tmrv.2010.11.003","DOI":"10.1016\/j.tmrv.2010.11.003"},{"key":"106635","doi-asserted-by":"crossref","unstructured":"Gandhi MJ, Strong DM, Whitaker BI, Petrisli E. A brief overview of clinical significance of blood group antibodies. Immunohematology. 2019;34:4-6.","DOI":"10.21307\/immunohematology-2018-002"},{"key":"106636","doi-asserted-by":"crossref","unstructured":"Wolff E, Jonsson B. Studien uber die untergruppen A1 and A2 mitesonderer berucksichtigung der paternitatsuntersuchungen. Dtsch Ztschr Gerichtl Med. 1933;22:65-85.","DOI":"10.1007\/BF01756867"},{"key":"106637","doi-asserted-by":"crossref","unstructured":"Khalid S, Dantes R, Varghese S, Al Hakawati I. Naturally occurring anti M complicating ABO grouping. Indian J Pathol Microbiol. 2011;54:170-2. https:\/\/doi.org\/110.4103\/0377-4929.77394","DOI":"10.4103\/0377-4929.77394"},{"key":"106638","doi-asserted-by":"crossref","unstructured":"Ugarte-Rubio L, Cestafe M, Lete I, Lapuente-Ocamica O, Gonz\u00e1lez-Calvi\u00f1o J. Enfermedad hemol\u00edtica perinatal causada por anticuerpos anti-M y tratada con inmunoglobulinas intravenosas fetales. Prog Obstet Ginecol. 2015;58:327-29. https:\/\/doi.org\/10.1016\/j.pog.2015.02.012","DOI":"10.1016\/j.pog.2015.02.012"},{"key":"106639","doi-asserted-by":"crossref","unstructured":"Suresh B, Sreedhar KV, Reji A, Jothibai DS. Prevalence of \u201cunexpected antibodies\u201d in the antenatal women attending the Government Maternity Hospital, Tirupati. J Clin Sci Res. 2015;4:22-30. https:\/\/doi.org\/10.15380\/2277-5706.JCSR.14.041","DOI":"10.15380\/2277-5706.JCSR.14.041"},{"key":"106640","doi-asserted-by":"crossref","unstructured":"Yasuda H, Ohto H, Nollet KE, Kawabata K, Saito S, Yagi Y, et al. Hemolytic disease of the fetus and newborn with late-onset anemia due to anti-M: A case report and review of the Japanese literature. Transfus Med Rev. 2014;28:1-6. https:\/\/doi.org\/10.1016\/j.tmrv.2013.10.002","DOI":"10.1016\/j.tmrv.2013.10.002"},{"key":"106641","doi-asserted-by":"crossref","unstructured":"Tondon R, Kataria R, Chaudhry R. Anti-M: Report of two cases and review of literature. Asian J Transfus Sci. 2008;2:81-3. https:\/\/doi.org\/10.4103\/0973-6247.42695","DOI":"10.4103\/0973-6247.42695"},{"key":"106642","doi-asserted-by":"crossref","unstructured":"Kaur G, Basu S, Kaur P, Kaur R. Clinically significant anti M antibodies --a report of two cases. 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