{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T08:11:30Z","timestamp":1781165490448,"version":"3.54.1"},"reference-count":28,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"Sp. 2","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["biomedica"],"abstract":"<jats:p>Introducci\u00f3n. La s\u00edfilis gestacional se considera de inter\u00e9s en salud p\u00fablica por las repercusiones que tiene en la madre y el hijo. Pese a tener protocolos para su notificaci\u00f3n, diagn\u00f3stico y manejo, en Colombia se siguen evidenciando limitaciones en su control.Objetivo. Describir las caracter\u00edsticas sociodemogr\u00e1ficas, cl\u00ednicas y de distribuci\u00f3n espacial de las pacientes con s\u00edfilis gestacional en Cali, Colombia, en el 2018.Materiales y m\u00e9todos. Se hizo un estudio transversal con 427 casos de s\u00edfilis gestacional reportados al Sistema de Vigilancia en Salud P\u00fablica (Sivigila). Para el procesamiento estad\u00edstico, se utiliz\u00f3 el programa R, versi\u00f3n 3.5.3. Las variables cualitativas se presentan como proporciones y, las cuantitativas, mediante medidas de tendencia central y dispersi\u00f3n, Para la distribuci\u00f3n espacial, se us\u00f3 el programa Qgis 3.0. Resultados. La raz\u00f3n de s\u00edfilis gestacional fue de 17 casos por 1.000 vivos (incluidos los mortinatos). El 57,1 % de las pacientes pertenec\u00eda al r\u00e9gimen subsidiado de salud y el 16,6 % no estaba asegurado. El 90,4 % de los casos se diagnostic\u00f3 durante el embarazo; el 47,2 % recibi\u00f3 tres dosis de penicilina y el 57,6 % de los contactos recibi\u00f3 tratamiento.Conclusiones. La tasa de s\u00edfilis gestacional en Cali en el 2018 fue superior a la nacional y la enfermedad se present\u00f3 con mayor frecuencia en mujeres gestantes en condici\u00f3n de vulnerabilidad socioecon\u00f3mica, lo que coincidi\u00f3 con la distribuci\u00f3n espacial en general. Se evidenci\u00f3 la falta de oportunidad en la detecci\u00f3n temprana y el manejo de la infecci\u00f3n tanto en las pacientes como en sus contactos, lo cual dificulta el control de la enfermedad y refleja la inadecuada aplicaci\u00f3n de la ruta integral de atenci\u00f3n en salud materno-perinatal.<\/jats:p>","DOI":"10.7705\/biomedica.6003","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T16:43:07Z","timestamp":1630946587000},"page":"140-152","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Caracter\u00edsticas sociodemogr\u00e1ficas y cl\u00ednicas de la s\u00edfilis gestacional en Cali, 2018"],"prefix":"10.7705","volume":"41","author":[{"given":"Juliana","family":"Ben\u00edtez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Alejandra","family":"Y\u00e9pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Hern\u00e1ndez-Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Milena","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Cubides-Munevar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Alirio","family":"Holgu\u00edn-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn Alonso","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"106343","doi-asserted-by":"crossref","unstructured":"Cruz-Aconcha AR. Situaci\u00f3n de la s\u00edfilis gestacional y cong\u00e9nita en Colombia, un desaf\u00edo al Sistema General de Seguridad Social en Salud. Rev Colomb Obstet Ginecol. 2012;63:304-7. https:\/\/doi.org\/10.18597\/rcog.133","DOI":"10.18597\/rcog.133"},{"key":"106344","unstructured":"Sabogal AL. Protocolo de vigilancia en salud p\u00fablica: s\u00edfilis gestacional y cong\u00e9nita. Bogot\u00e1, D.C.: Instituto Nacional de Salud; 2017. p. 1-17. Fecha de consulta: 12 de febrero de 2020. Disponible en: https:\/\/www.ins.gov.co\/buscador-eventos\/Lineamientos\/PRO%20Sifilis_.pdf"},{"key":"106345","doi-asserted-by":"crossref","unstructured":"Korenromp EL, Rowley J, Alonso M, Mello MB, Wijesooriya NS, Mahian\u00e9 SG, et al. Global burden of maternal and congenital syphilis and associated adverse birth outcomes\u2014Estimates for 2016 and progress since 2012. PLoS ONE. 2019;14:1-17. https:\/\/doi.org\/10.1371\/journal.pone.0211720","DOI":"10.1371\/journal.pone.0219613"},{"key":"106346","doi-asserted-by":"crossref","unstructured":"Peeling RW, Hook III EW. The pathogenesis of syphilis: The Great Mimicker, revisited. J Pathol. 2006;208:224-32. https:\/\/doi.org\/10.1002\/path.1903","DOI":"10.1002\/path.1903"},{"key":"106347","doi-asserted-by":"crossref","unstructured":"Carlson JA, Dabiri G, Cribier B, Sell S. The immunopathobiology of syphilis: The manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity. Am J Dermatopathol. 2011;33:433-60. https:\/\/doi.org\/10.1097\/DAD.0b013e3181e8b587","DOI":"10.1097\/DAD.0b013e3181e8b587"},{"key":"106348","doi-asserted-by":"crossref","unstructured":"Tsimis ME, Sheffield JS. Update on syphilis and pregnancy. Birth Defects Res. 2017;109:347-52. https:\/\/doi.org\/10.1002\/bdra.23562","DOI":"10.1002\/bdra.23562"},{"key":"106349","doi-asserted-by":"crossref","unstructured":"De Santis M, De Luca C, Mappa I, Spagnuolo T, Licameli A, Straface G, et al. Syphilis infection during pregnancy: Fetal risks and clinical management. Infect Dis Obstet Gynecol. 2012;2012:1-5. https:\/\/doi.org\/10.1155\/2012\/430585","DOI":"10.1155\/2012\/430585"},{"key":"106350","doi-asserted-by":"crossref","unstructured":"Arnesen L, Mart\u00ednez G, Mainero L, Serruya S, Dur\u00e1n P. Gestational syphilis and stillbirth in Latin America and the Caribbean. Int J Gynecol Obstet. 2015;128:241-5. https:\/\/doi.org\/10.1016\/j.ijgo.2014.09.017","DOI":"10.1016\/j.ijgo.2014.09.017"},{"key":"106351","unstructured":"Workowski KA, Bolan GA, Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Morb Mortal Wkly Rep. 2015;64:1-137."},{"key":"106352","unstructured":"Castellanos LG, Ghidinelli M, Kurtis H, Mello MB, P\u00e9rez F, Ropero AM, et al. ETMI-PLUS: marco para la eliminaci\u00f3n de la transmisi\u00f3n maternoinfantil del VIH, la s\u00edfilis, la hepatitis y la enfermedad de Chagas. Washington, D.C.: Organizaci\u00f3n Panamericana de la Salud; 2017."},{"key":"106353","unstructured":"p. 1-30. Fecha de consulta: 9 de diciembre de 2019. Disponible en: https:\/\/www.paho.org\/hq\/dmdocuments\/2017\/2017-cha-etmi-plus-marco-vih-hep-chagas.pdf"},{"key":"106354","unstructured":"Sabogal AL. Informe de s\u00edfilis gestacional periodo epidemiol\u00f3gico XIII - 2018. Bogot\u00e1, D.C.: Instituto Nacional de Salud; 2018. Fecha de consulta: 1 de abril de 2019. Disponible en: https:\/\/www.ins.gov.co\/buscador-eventos\/Informesdeevento\/SIF%C3%8DLIS%20GESTACIONAL%20Y%20CONG%C3%89NITA_2018.pdf"},{"key":"106355","unstructured":"Ministerio de Salud y Protecci\u00f3n Social. Lineamiento t\u00e9cnico y operativo de la Ruta Integral de Atenci\u00f3n en Salud Materno Perinatal. Bogot\u00e1, D.C.: Minsalud; 2017."},{"key":"106356","unstructured":"ONUSIDA. Avanzando hacia las metas 2020: Progreso en Am\u00e9rica Latina y el Caribe. 2019. Fecha de consulta: 13 de junio de 2021. Disponible en: https:\/\/reliefweb.int\/sites\/reliefweb.int\/files\/resources\/73659-1.pdf"},{"key":"106357","unstructured":"Mora CP, Duque S, Perlaza G, Faride M, Mart\u00ednez G, Holgu\u00edn J. An\u00e1lisis de Situaci\u00f3n Integrado de Salud (ASIS) de Santiago de Cali - A\u00f1o 2017. Cali: Secretar\u00eda de Salud P\u00fablica Municipal de Cali; 2017. p. 1-134."},{"key":"106358","unstructured":"Secretar\u00eda de Salud P\u00fablica Municipal de Cali. Estad\u00edsticas Vitales. Cali: Secretar\u00eda de Salud P\u00fablica Municipal de Cali; 2018. Fecha de consulta: 17 de septiembre de 2019."},{"key":"106359","doi-asserted-by":"crossref","unstructured":"Galeano CL, Garc\u00eda WD, Congote LM, V\u00e9lez MA, Mart\u00ednez DM. Prevalencia de s\u00edfilis gestacional e incidencia de s\u00edfilis cong\u00e9nita, Cali, Colombia, 2010. Rev Colomb Obstet Ginecol. 2012;63:321-6. https:\/\/doi.org\/https:\/\/doi.org\/10.18597\/rcog.136","DOI":"10.18597\/rcog.136"},{"key":"106360","doi-asserted-by":"crossref","unstructured":"Agudelo RD, Medina MC, Cardona D. Caracterizaci\u00f3n de la s\u00edfilis cong\u00e9nita y gestacional en Caldas, Colombia. Arch Med (Manizales). 2016;16:326-34. https:\/\/doi.org\/10.30554\/archmed.16.2.1736.2016","DOI":"10.30554\/archmed.16.2.1736.2016"},{"key":"106361","unstructured":"Ochoa MT, Gait\u00e1n HG, Caicedo S, G\u00f3mez B, P\u00e9rez F. Introducci\u00f3n de pruebas r\u00e1pidas para s\u00edfilis y VIH en el control prenatal en Colombia: an\u00e1lisis cualitativo. Rev Panam Salud P\u00fablica. 2016;40:462-7."},{"key":"106362","unstructured":"Alonso M, Mello M. Elimination of mother-to-child transmission of HIV and syphilis in the Americas: Update 2016. Washington, D.C.; PAHO: 2017. p. 1-62. Fecha de consulta: 8 de diciembre de 2019. Disponible en: http:\/\/iris.paho.org\/xmlui\/bitstream\/handle\/123456789\/34072\/9789275119556-eng.pdf?sequence=4&isAllowed=y"},{"key":"106363","doi-asserted-by":"crossref","unstructured":"Gramazio L, Zarpellon B, Gramazio L, Baratieri T, Lentsck MH, de Azevedo V. Gestational and congenital syphilis: Maternal, neonatal characteristics and outcome of cases. Rev Bras Sa\u00fade Matern Infant. 2017;17:781-9. https:\/\/doi.org\/10.1590\/1806-93042017000400010","DOI":"10.1590\/1806-93042017000400010"},{"key":"106364","doi-asserted-by":"crossref","unstructured":"Padovani C, Rosseto de Oliveira R, Pelloso SM. Syphilis during pregnancy: Association of maternal and perinatal characteristics in a region of southern Brazil. Rev Latino-Am Enfermagem. 2018;26:1-10. https:\/\/doi.org\/10.1590\/1518-8345.2305.3019","DOI":"10.1590\/1518-8345.2305.3019"},{"key":"106365","doi-asserted-by":"crossref","unstructured":"Amador C, Lavalle MH, Chamorro MV. S\u00edfilis gestacional: enfermedad de inter\u00e9s en salud p\u00fablica, C\u00f3rdoba-Colombia, 2015. Rev Cuid. 2017;8:1449-58. https:\/\/doi.org\/10.15649\/cuidarte.v8i1.350","DOI":"10.15649\/cuidarte.v8i1.350"},{"key":"106366","unstructured":"Silva AM, Bois F, Duro E. Factores asociados con falla en el diagn\u00f3stico y tratamiento de s\u00edfilis materna. Medicina Infantil. 2016;XXIII:293-8."},{"key":"106367","unstructured":"Panosso de Freitas E, Dell Agnolo CM, Borges L, Pelloso SM, Bercini LO, Harumi I. Percep\u00e7\u00e3o de adolescentes sobre a pr\u00e1tica sexual na adolesc\u00eancia. Revista de Psicologia da Crian\u00e7a e do Adolescente. 2014;5:139-49."},{"key":"106368","unstructured":"Escobar G, Perilla DM. Cali en cifras 2018-2019. Cali: Departamento Administrativo de Planeaci\u00f3n, Alcald\u00eda de Santiago de Cali; 2019."},{"key":"106369","unstructured":"P\u00e1ez GN, Jaramillo LF, Franco C, Arregoces L, Bardey D, Ortiz JL, et al. Estudio sobre el modo de gestionar la salud en Colombia. Bogot\u00e1, D.C.: Ministerio de Salud y Protecci\u00f3n Social; 2015. Fecha de consulta: 5 de noviembre de 2019. Disponible en: https:\/\/www.minsalud.gov.co\/sites\/rid\/Lists\/BibliotecaDigital\/RIDE\/DE\/AS\/gestionar%20la%20salud%20en%20Colombia.pdf"},{"key":"106370","doi-asserted-by":"crossref","unstructured":"Garc\u00e9s JP, Rubiano LC, Orobio Y, Casta\u00f1o M, Benavides E, Cruz A. La educaci\u00f3n del personal de salud: clave para la eliminaci\u00f3n de la s\u00edfilis cong\u00e9nita en Colombia. Biom\u00e9dica. 2017;37:416-24. https:\/\/doi.org\/10.7705\/biomedica.v37i3.3397","DOI":"10.7705\/biomedica.v37i3.3397"}],"container-title":["Biom\u00e9dica"],"original-title":[],"link":[{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/6003\/4888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/6003\/4888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T16:05:17Z","timestamp":1634745917000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/view\/6003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":28,"journal-issue":{"issue":"Sp. 2","published-online":{"date-parts":[[2021,10,15]]}},"URL":"https:\/\/doi.org\/10.7705\/biomedica.6003","relation":{},"ISSN":["2590-7379","0120-4157"],"issn-type":[{"value":"2590-7379","type":"electronic"},{"value":"0120-4157","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10,15]]},"assertion":[{"value":"2021-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer Reviewed","group":{"name":"peer_review","label":"Peer Review"}},{"value":"Instituto Nacional de Salud","name":"publisher","label":"This article is maintained by"},{"value":"Biomedica","name":"journaltitle","label":"Journal Title"},{"value":"Original article","name":"content_type","label":"Content Type"}]}}