{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:56:58Z","timestamp":1791413818964,"version":"4.3.3"},"reference-count":25,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"3","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["biomedica"],"abstract":"<jats:p>Introducci\u00f3n. Las infecciones asociadas con la atenci\u00f3n en salud constituyen un problema de salud p\u00fablica porque aumentan la morbimortalidad de los pacientes, sobre todo de aquellos con factores de riesgo, como la inmunosupresi\u00f3n debida a enfermedades oncol\u00f3gicas. Es importante conocer la diversidad gen\u00e9tica de losprincipales microorganimos causantes de infecciones hospitalarias mediante la vigilancia epidemiol\u00f3gica tradicional y la epidemiolog\u00eda molecular, para hacer un mejor seguimiento y detectar brotes tempranamente.Objetivo. Determinar el grupo filogen\u00e9tico y la resistencia a antibi\u00f3ticos de las cepas de Escherichia coli aisladas de pacientes con c\u00e1ncer hospitalizados.Materiales y m\u00e9todos. Se hizo un estudio de tipo transversal que incluy\u00f3 67 cepas de Escherichia coli productoras de betalactamasas de espectro extendido (BLEE). Se determin\u00f3 el grupo filogen\u00e9tico, el perfil de resistencia a los antibi\u00f3ticos, los genes de resistencia a betalact\u00e1micos, el tipo de las muestras y los servicios de hospitalizaci\u00f3n de donde fueron recuperadas.Resultados. El grupo filogen\u00e9tico m\u00e1s frecuente fue el B2 (36 %). El 57 % de las cepas B2 fueron aisladas de muestras de orina y el 33 % proven\u00eda del servicio de urolog\u00eda. La resistencia a ciprofloxacino y gentamicina fue de 91 y 53 %, respectivamente, y el 79 % de las cepas ten\u00eda el gen blaCTX-M. Se encontr\u00f3 una relaci\u00f3n significativa (p&lt;0,05) entre los grupos filogen\u00e9ticos y la resistencia a ciprofloxacina, as\u00ed como a la edad del paciente.Conclusi\u00f3n. El filogrupo de E. coli predominante fue el B2. Se evidenci\u00f3 una gran resistencia a ciprofloxacina y gentamicina, una proporci\u00f3n elevada de cepas BLEE con el blaCTX-M, y una relaci\u00f3n entre el grupo filogen\u00e9tico y la resistencia a ciprofloxacino.<\/jats:p>","DOI":"10.7705\/biomedica.6263","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T19:09:32Z","timestamp":1663614572000},"page":"470-478","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Filogenia y resistencia de cepas de Escherichia coli productoras de betalactamasas de espectro extendido a los antibi\u00f3ticos en pacientes con c\u00e1ncer hospitalizados en Per\u00fa"],"prefix":"10.7705","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-4839","authenticated-orcid":false,"given":"Jose","family":"Matta-Chuquisapon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-9842","authenticated-orcid":false,"given":"Esther","family":"Valencia-Bazalar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9938-9922","authenticated-orcid":false,"given":"Carlos","family":"Sevilla-Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4041-4406","authenticated-orcid":false,"given":"Hel\u00ed Jaime","family":"Barr\u00f3n-Pastor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"110128","unstructured":"Organizaci\u00f3n Panamericana de la Salud. Vigilancia epidemiol\u00f3gica de las infecciones asociadas a la atenci\u00f3n de la salud en neonatolog\u00eda. M\u00f3dulo IV - PAHO; 2013. Fecha de consulta: 18 de febrero de 2022. Disponible en: https:\/\/iris.paho.org\/handle\/10665.2\/31361"},{"key":"110129","doi-asserted-by":"crossref","unstructured":"Yagui-Moscoso M, Vidal-Anzardo M, Rojas-Mezarina L, Sanabria-Rojas H. Prevenci\u00f3n de infecciones asociadas a la atenci\u00f3n de salud: conocimientos y pr\u00e1cticas en m\u00e9dicos residentes. An Fac Med. 2021;82:131-9. https:\/\/doi.org\/10.15381\/anales.v82i2.19839","DOI":"10.15381\/anales.v82i2.19839"},{"key":"110130","doi-asserted-by":"crossref","unstructured":"Johnson JR, Russo TA. Molecular epidemiology of extraintestinal pathogenic Escherichia coli. EcoSal Plus. 2018;8:1-32. https:\/\/doi.org\/10.1128\/ecosalplus.ESP-0004-2017","DOI":"10.1128\/ecosalplus.ESP-0004-2017"},{"key":"110131","doi-asserted-by":"crossref","unstructured":"Bonilla-Marciales AP, Ch\u00e1vez-Ca\u00f1as WO, Hern\u00e1ndez-Mogoll\u00f3n RA, Ram\u00f3n-Jaimes NA. Estrategias de prevenci\u00f3n y control de las infecciones en pacientes oncol\u00f3gicos. MedUNAB. 2019;22:356-68.","DOI":"10.29375\/01237047.3376"},{"key":"110132","unstructured":"Vel\u00e1zquez-Brizuela IE, Aranda-Gama J, Camacho-Cort\u00e9s JL, Ortiz GG. Epidemiolog\u00eda de infecciones nosocomiales en el Instituto Jalisciense de Cancerolog\u00eda. Rev Cuba Salud P\u00fablica. 2013;39:19-31."},{"key":"110133","doi-asserted-by":"crossref","unstructured":"Clermont O, Christenson JK, Denamur E, Gordon DM. The Clermont Escherichia coli phylo-typing method revisited: Improvement of specificity and detection of new phylo-groups. 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Pan Afr Med J. 2020;37:213. https:\/\/doi.org\/10.11604\/pamj.2020.37.213.24988","DOI":"10.11604\/pamj.2020.37.213.24988"},{"key":"110143","doi-asserted-by":"crossref","unstructured":"Demirci M, \u00dcnl\u00fc \u00d6, \u0130stanbullu Tosun A. Detection of O25b-ST131 clone, CTX-M-1 and CTX-M-15 genes via real-time PCR in Escherichia coli strains in patients with UTIs obtained from a university hospital in Istanbul. J Infect Public Health. 2019;12:640-4. https:\/\/doi.org\/10.1016\/j.jiph.2019.02.017","DOI":"10.1016\/j.jiph.2019.02.017"},{"key":"110144","unstructured":"Hern\u00e1ndez E, Araque M, Mill\u00e1n Y, Mill\u00e1n B. Prevalencia de b-lactamasa CTX-M-15 en grupos filogen\u00e9ticos de Escherichia coli uropat\u00f3gena aisladas en pacientes de la comunidad en M\u00e9rida, Venezuela. Invest Clin. 2014;55:13."},{"key":"110145","doi-asserted-by":"crossref","unstructured":"Galindo-M\u00e9ndez M. 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