{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T14:23:55Z","timestamp":1747232635243,"version":"3.40.5"},"reference-count":32,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"Sp. 1","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["biomedica"],"abstract":"<jats:p>En su estado fresco, la membrana amniocori\u00f3nica contiene varias c\u00e9lulas multipotenciales, factores de crecimiento y prote\u00ednas de la matriz extracelular que contribuyen a la cicatrizaci\u00f3n de las \u00falceras vasculares cr\u00f3nicas. Para demostrar su efectividad, se recurri\u00f3 a un aloinjerto de membrana placentaria humana fresca para tratar una \u00falcera venosa cr\u00f3nica, de 12 x 10 cm y con 40 a\u00f1os de evoluci\u00f3n, en el zona maleolar interna e izquierda de una paciente de 89 a\u00f1os de edad. Transcurridos 60 d\u00edas del injerto, la \u00falcera se encontraba cicatrizada en el 100 % de su superficie, observ\u00e1ndose una cicatriz rosada clara en cuyos bordes se apreciaron intentos de pigmentaci\u00f3n. El aloinjerto de membrana amniocori\u00f3nica humana fresca es una alternativa terap\u00e9utica para la curaci\u00f3n de \u00falceras vasculares cr\u00f3nicas persistentes en las extremidades inferiores.<\/jats:p>","DOI":"10.7705\/biomedica.6319","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T15:21:02Z","timestamp":1657725662000},"page":"17-25","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Curaci\u00f3n de \u00falcera venosa cr\u00f3nica de la pierna con aloinjerto de membrana amniocori\u00f3nica humana fresca"],"prefix":"10.7705","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6913-4275","authenticated-orcid":false,"given":"Alberto","family":"Piamo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8381-8745","authenticated-orcid":false,"given":"Mayra","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-6252","authenticated-orcid":false,"given":"Dayset","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3682-9147","authenticated-orcid":false,"given":"Daisy","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2022,5,1]]},"reference":[{"key":"108140","unstructured":"Nelson EA, Adderley U. 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