{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:22:19Z","timestamp":1775618539312,"version":"3.50.1"},"reference-count":31,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"1","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>La sinusitis mic\u00f3tica es una condici\u00f3n patol\u00f3gica que puede presentarse en pacientes con diabetes mellitus y estar asociada a una crisis hipergluc\u00e9mica. Es una entidad agresiva con complicaciones locales que incluyen afectaci\u00f3n de la \u00f3rbita y el sistema nervioso central, y compromiso vascular. A pesar del tratamiento quir\u00fargico y antimic\u00f3tico, la mortalidad es de hasta el 75 %.Se describe el caso de una paciente con diagn\u00f3stico de cetoacidosis diab\u00e9tica y signos de oftalmoplej\u00eda unilateral que llevaron al estudio con resonancia magn\u00e9tica del sistema nervioso central; se encontraron signos de sinusitis, meningitis y cerebritis. Los estudios microbiol\u00f3gicos iniciales fueron negativos, y los biomarcadores galactomanano s\u00e9rico y el ant\u00edgeno de Cryptococcus tambi\u00e9n fueron negativos. Tras el manejo quir\u00fargico, se lleg\u00f3 a la identificaci\u00f3n de Aspergillus flavus y Rhizopus spp. en el tejido de los senos paranasales. La paciente recibi\u00f3 tratamiento con posaconazol y, tras dos meses de seguimiento, hab\u00eda presentado mejor\u00eda cl\u00ednica. La infecci\u00f3n f\u00fangica dual y la infecci\u00f3n por A. flavus son entidades poco frecuentes y de relevancia cl\u00ednica, sin casos presentados previamente en nuestro pa\u00eds por lo que este corresponde a un caso de inter\u00e9s cl\u00ednico.<\/jats:p>","DOI":"10.7705\/biomedica.6358","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T15:34:40Z","timestamp":1682609680000},"page":"27-36","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Infecci\u00f3n por Aspergillus flavus y Rhizopus oryzae complex en paciente con diabetes mellitus","Infection due to Aspergillus flavus and Rhizopus oryzae complex in a patient with diabetes mellitus"],"prefix":"10.7705","volume":"43","author":[{"given":"Mar\u00eda Alejandra","family":"P\u00e9rez","sequence":"first","affiliation":[{"name":"Departamento de Infectolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Departamento de Infectolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Departamento de Microbiolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Bravo","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Departamento de Patolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Departamento de Medicina Interna, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Quintero","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Departamento de Medicina Interna, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-3016","authenticated-orcid":false,"given":"Pablo","family":"Moncada","sequence":"additional","affiliation":[{"name":"Departamento de Infectolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Departamento de Infectolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"117630","doi-asserted-by":"crossref","unstructured":"Trief D, Gray ST, Jakobiec FA, Durand ML, Fay A, Freitag SK, et al. 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