{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T10:17:04Z","timestamp":1715768224191},"reference-count":10,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"3","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["biomedica"],"abstract":"<jats:p>El s\u00edndrome neurol\u00e9ptico maligno es una condici\u00f3n cl\u00ednica rara y potencialmente letal que frecuentemente se asocia con el uso de antipsic\u00f3ticos. En la literatura especializada se encontr\u00f3 \u00fanicamente un reporte de caso relacionado con la ingesti\u00f3n de organofosforados.Se presenta un paciente con un cuadro cl\u00ednico correspondiente al s\u00edndrome neurol\u00e9ptico maligno posterior a la ingesti\u00f3n de clorpirif\u00f3s. Como resultado de un intento de suicidio con el mencionado organofosforado, el hombre de 57 a\u00f1os present\u00f3 deterioro agudo del estado de consciencia, evoluci\u00f3n neurol\u00f3gica t\u00f3rpida e inestabilidad auton\u00f3mica asociada a rigidez e hipertermia persistentes, as\u00ed como incremento de la creatina-fosfocinasa (creatine phosphokinase, CPK). Se le administr\u00f3 tratamiento con bromocriptina, con lo cual el cuadro cl\u00ednico remiti\u00f3, y fue dado de alta sin secuelas.El diagn\u00f3stico del s\u00edndrome neurol\u00e9ptico maligno es cl\u00ednico y debe contemplarse en cualquier caso de exposici\u00f3n a sustancias que puedan resultar en una desregulaci\u00f3n de la neurotransmisi\u00f3n dopamin\u00e9rgica, con el fin de iniciar el tratamiento oportuno y contrarrestar efectivamente los efectos.<\/jats:p>","DOI":"10.7705\/biomedica.6428","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T19:09:32Z","timestamp":1663614572000},"page":"445-449","update-policy":"http:\/\/dx.doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["S\u00edndrome neurol\u00e9ptico maligno asociado con intoxicaci\u00f3n aguda por un organofosforado: reporte de caso"],"prefix":"10.7705","volume":"42","author":[{"given":"Nancy Y.","family":"Angulo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula A.","family":"Casta\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crhistian C.","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Quintero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"109621","doi-asserted-by":"crossref","unstructured":"Uprety A, Pantha B, Karki L, Nepal SP, Khadka M. 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