{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:58:48Z","timestamp":1787032728285,"version":"build-2736575974"},"reference-count":25,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"2","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>El d\u00e9ficit de cobre puede presentarse como una mielopat\u00eda y manifestarse como una ataxia sensorial secundaria a una desmielinizaci\u00f3n de los cordones posteriores de la m\u00e9dula espinal. Puede acompa\u00f1arse de citopenias, principalmente anemia y leucopenia.Se presenta una serie de casos de tres pacientes con mielopat\u00eda por d\u00e9ficit de cobre, diagnosticados y manejados desde el a\u00f1o 2020 al 2022 en un hospital universitario de alta complejidad en Colombia.Dos de los casos eran mujeres. El rango de edad fue entre 57 y 68 a\u00f1os. En los tres casos, los niveles s\u00e9ricos de cobre estaban disminuidos y en dos de ellos, se descartaron diferentes causas de mielopat\u00eda que afectan los cordones posteriores de la m\u00e9dula espinal como el d\u00e9ficit de vitamina B12, vitamina E y \u00e1cido f\u00f3lico, tabes dorsal, mielopat\u00eda por virus de la inmunodeficiencia humana, esclerosis m\u00faltiple e infecci\u00f3n por el virus linfotr\u00f3pico humano de tipo I y II, entre otras. Sin embargo, un paciente ten\u00eda deficiencia de vitamina B12 asociada con de cobre en el momento del diagn\u00f3stico de la mielopat\u00eda. En los tres casos hubo ataxia sensitiva y en dos, la paraparesia fue el d\u00e9ficit motor inicial.<\/jats:p>","DOI":"10.7705\/biomedica.6687","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T12:52:57Z","timestamp":1689079977000},"page":"171-180","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Mielopat\u00eda por d\u00e9ficit de cobre: serie de casos y revisi\u00f3n de la literatura","Myelopathy due to copper deficiency: A case series and review of the literature"],"prefix":"10.7705","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9192-2566","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Pe\u00f1a","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander (FOSCAL), Bucaramanga, Colombia; Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Bucaramanga, Bucaramanga, Colombia"},{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander (FOSCAL), Bucaramanga, Colombia; Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Bucaramanga, Bucaramanga, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-0933","authenticated-orcid":false,"given":"Juan","family":"Sarmiento","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander (FOSCAL), Bucaramanga, Colombia; Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Bucaramanga, Bucaramanga, Colombia"},{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander (FOSCAL), Bucaramanga, Colombia; Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Bucaramanga, Bucaramanga, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-0744","authenticated-orcid":false,"given":"Cristian","family":"Porras","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander (FOSCAL), Bucaramanga, Colombia; Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Bucaramanga, Bucaramanga, Colombia"},{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander (FOSCAL), Bucaramanga, Colombia; Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Bucaramanga, Bucaramanga, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3983-2774","authenticated-orcid":false,"given":"Ximena","family":"Cediel","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander (FOSCAL), Bucaramanga, Colombia"},{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander (FOSCAL), Bucaramanga, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8243-0597","authenticated-orcid":false,"given":"Ana","family":"Camargo","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander (FOSCAL), Bucaramanga, Colombia; Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Bucaramanga, Bucaramanga, Colombia"},{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander (FOSCAL), Bucaramanga, Colombia; Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Bucaramanga, Bucaramanga, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"120878","doi-asserted-by":"crossref","unstructured":"Altarelli M, Ben-hamouda N, Schneider A, Berger M. 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