{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:52:35Z","timestamp":1773867155773,"version":"3.50.1"},"reference-count":42,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"Sp. 1","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>La histoplasmosis es una micosis end\u00e9mica en Colombia. Se presentan dos casos del departamento del Cauca, para mostrar el impacto cl\u00ednico que conlleva un retraso en su diagn\u00f3stico y tratamiento. Se obtuvo el consentimiento informado para revisar las historias cl\u00ednicas de los pacientes y publicar los casos.El primer caso se trata de un paciente con infecci\u00f3n por el virus de inmunodeficiencia humana (Human Immunodeficiency Virus, HIV), quien presentaba lesiones cut\u00e1neas generalizadas atribuidas inicialmente al virus del herpes; post mortem y mediante el cultivo para hongos de muestras de las lesiones d\u00e9rmicas, se confirm\u00f3 el diagn\u00f3stico de histoplasmosis. El segundo caso es un paciente inmunocompetente con sintomatolog\u00eda pulmonar, a quien se le diagnostic\u00f3 tuberculosis cl\u00ednicamente y se le instaur\u00f3 tratamiento; sin embargo, ante la nula mejor\u00eda y teniendo en cuenta el antecedente de ingreso a una cueva de murci\u00e9lagos, se enfoc\u00f3 como una posible histoplasmosis pulmonar y se obtuvo mejor\u00eda con el tratamiento.Se revis\u00f3 la literatura sobre las pruebas de laboratorio y los datos epidemiol\u00f3gicos de histoplasmosis que deben considerar los profesionales de la salud. Se concluy\u00f3 que las instituciones de salud deben disponer de pruebas r\u00e1pidas (por ejemplo, antig\u00e9nicas) para el diagn\u00f3stico y tratamiento adecuado de esta micosis, adem\u00e1s de adoptar los correctivos necesarios para minimizar la exposici\u00f3n a Histoplasma.<\/jats:p>","DOI":"10.7705\/biomedica.6782","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T10:18:35Z","timestamp":1695032315000},"page":"20-31","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["La importancia de la correlaci\u00f3n cl\u00ednico-epidemiol\u00f3gica en el diagn\u00f3stico temprano de la histoplasmosis: reporte de dos casos cl\u00ednicos en Popay\u00e1n, Colombia","The relevance of clinical and epidemiological correlation in the early diagnosis of histoplasmosis: report of two clinical cases in Popay\u00e1n, Colombia"],"prefix":"10.7705","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4608-4997","authenticated-orcid":false,"given":"Jorge Andr\u00e9s","family":"Potos\u00ed","sequence":"first","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda y Parasitolog\u00eda, Facultad Ciencias de la Salud, Universidad del Cauca, Popay\u00e1n, Colombia"},{"name":"Laboratorio de Microbiolog\u00eda y Parasitolog\u00eda, Facultad Ciencias de la Salud, Universidad del Cauca, Popay\u00e1n, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1540-2080","authenticated-orcid":false,"given":"Yina Marcela","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda y Parasitolog\u00eda, Facultad Ciencias de la Salud, Universidad del Cauca, Popay\u00e1n, Colombia"},{"name":"Laboratorio de Microbiolog\u00eda y Parasitolog\u00eda, Facultad Ciencias de la Salud, Universidad del Cauca, Popay\u00e1n, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1575-1619","authenticated-orcid":false,"given":"Fabiola Eugenia","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda y Parasitolog\u00eda, Facultad Ciencias de la Salud, Universidad del Cauca, Popay\u00e1n, Colombia"},{"name":"Laboratorio de Microbiolog\u00eda y Parasitolog\u00eda, Facultad Ciencias de la Salud, Universidad del Cauca, Popay\u00e1n, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"123321","doi-asserted-by":"crossref","unstructured":"Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, et al. 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