{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:11:27Z","timestamp":1773367887859,"version":"3.50.1"},"reference-count":32,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"1","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introduction. Although Chagas disease causes high levels of morbidity, the muscle function and tolerance to physical activity in Chagas disease patients are still not completely understood.Objective. To compare health-related fitness of patient groups with acute Chagas disease versus chronic Chagas disease.Materials and methods. We conducted a cross-sectional study involving 18 patients. The data were obtained from patient\u00b4s records, and functional capacity was measured with the sixminute walk test, the peripheral muscle strength with handgrip strength, and respiratory muscle strength using the maximum inspiratory pressure and the maximum expiratory pressure.Results. The 18 patients were divided in two groups: acute Chagas disease (n=9) and chronic Chagas disease (n=9). The distance walked in the six-minute walk test was lower than the predicted distance walked in both groups (p &lt; 0.0001). The maximum expiratory pressure was lower than the predicted one (p = 0.005), and statistically significant for chronic Chagas disease patients (p = 0.02). Heart rate increased faster in the chronic Chagas disease group within the first two minutes of the six-minute walk test (p = 0.04). The sixminute walk test in the acute Chagas disease group presented a strong correlation with peripheral muscle strength (p = 0.012) and maximum inspiratory pressure (p = 0.0142), while in the chronic Chagas disease group, only peripheral muscle strength and maximum inspiratory pressure were correlated (p = 0.0259).Conclusion. The results suggest lowered functional capacity and reduced respiratory and peripheral muscle strength in patients with Chagas disease, although no differences were observed between groups. The early increase in heart rate during exercise in the chronic Chagas disease group implies a greater myocardial overload.<\/jats:p>","DOI":"10.7705\/biomedica.6892","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T15:23:00Z","timestamp":1713280980000},"page":"67-79","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Comparative analysis of health-related fitness in patients with acute versus chronic Chagas disease","An\u00e1lisis comparativo del estado f\u00edsico relacionado con la salud en pacientes con enfermedad aguda versus cr\u00f3nica de Chagas"],"prefix":"10.7705","volume":"44","author":[{"family":"Clara Narcisa Silva Almeida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ariane Cardoso Vasconcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Caroline da Silva Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-6727","authenticated-orcid":false,"given":"Nivea Thayanne","family":"Melo Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Human Movement Sciences, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"},{"name":"Postgraduate Program in Human Movement Sciences, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Dilma do Socorro Moraes de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Carlos Alberto Marques de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Suellen Alessandra Soares de Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Laura Maria Tomazi Neves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2024,3,31]]},"reference":[{"key":"132101","doi-asserted-by":"crossref","unstructured":"Dias JC, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. 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