{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:10:28Z","timestamp":1773367828663,"version":"3.50.1"},"reference-count":25,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"1","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>El dicloruro de 1,1\u2019-dimetil-4,4\u2019-bipiridilo (Paraquat\u00ae) es un compuesto qu\u00edmico de la familia de las piridinas, utilizado como herbicida no selectivo y desecante. Este compuesto puede causar intoxicaci\u00f3n aguda por todas las v\u00edas de exposici\u00f3n. En el momento, no hay un ant\u00eddoto conocido y los tratamientos disponibles, incluidos los pedi\u00e1tricos, se basan en contrarrestar su absorci\u00f3n y propiciar su remoci\u00f3n oportuna.Se describe una serie de casos de 14 pacientes pedi\u00e1tricos, procedentes en su mayor\u00eda del departamento del Cauca, con intoxicaci\u00f3n aguda por ingesti\u00f3n de paraquat. Los pacientes fueron remitidos y atendidos en un hospital de mediana a alta complejidad en el suroccidente colombiano, con un protocolo institucional para el manejo de la intoxicaci\u00f3n aguda por el herbicida.La intoxicaci\u00f3n aguda con paraquat por v\u00eda oral se asocia con una alta tasa de mortalidad, a\u00fan con atenci\u00f3n m\u00e9dica oportuna, pues f\u00e1cilmente se alcanzan concentraciones sist\u00e9micas para ser fulminante. Basado en la literatura disponible, el Hospital Universitario San Jos\u00e9 ha propuesto un protocolo cl\u00ednico \u2013adecuado para la intoxicaci\u00f3n aguda por paraquat en poblaci\u00f3n pedi\u00e1trica\u2013 que incluye manejo est\u00e1ndar temprano, tratamiento inmunosupresor y antioxidante, y t\u00e9cnicas para su remoci\u00f3n sist\u00e9mica.<\/jats:p>","DOI":"10.7705\/biomedica.7024","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T15:23:00Z","timestamp":1713280980000},"page":"16-34","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Algoritmo de manejo hospitalario para la intoxicaci\u00f3n aguda por Paraquat\u00ae en poblaci\u00f3n pedi\u00e1trica, serie de casos","A hospital management algorithm for acute poisoning by Paraquat\u00ae in a pediatric population, a series of cases"],"prefix":"10.7705","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-6111","authenticated-orcid":false,"given":"Alejandro","family":"Padilla-Guzm\u00e1n","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3883-664X","authenticated-orcid":false,"given":"Olga L.","family":"Prado","sequence":"additional","affiliation":[{"name":"Nefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"},{"name":"Nefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-8823","authenticated-orcid":false,"given":"David","family":"Ballesteros","sequence":"additional","affiliation":[{"name":"Nefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"},{"name":"Nefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-1681","authenticated-orcid":false,"given":"Viviana","family":"Rivera","sequence":"additional","affiliation":[{"name":"Nefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"},{"name":"Nefrolog\u00eda y Cuidado Intensivo pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, ColombiaNefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yessica","family":"Bravo","sequence":"additional","affiliation":[{"name":"Nefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"},{"name":"Nefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Murillo","sequence":"additional","affiliation":[{"name":"Nefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"},{"name":"Nefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Narv\u00e1ez","sequence":"additional","affiliation":[{"name":"Nefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"},{"name":"Nefrolog\u00eda y Cuidado Intensivo Pedi\u00e1trico, Hospital Universitario San Jos\u00e9, Popay\u00e1n, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6526-757X","authenticated-orcid":false,"given":"Jessica M.","family":"Forero","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Valle del Lili, Cali, Colombia; Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"},{"name":"Servicio de Nefrolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Valle del Lili, Cali, Colombia; Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2024,3,31]]},"reference":[{"key":"131844","doi-asserted-by":"crossref","unstructured":"Ballesteros D, Soto Oviedo A, Murillo Palacios J, Garc\u00eda C. 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