{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:07:37Z","timestamp":1776985657655,"version":"3.51.4"},"reference-count":5,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"1","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introduction. During the SARS-CoV-2 pandemic, many countries experienced decreased respiratory virus circulation, followed by an out-of-season outbreak. In a pediatric hospital in Colombia, we observed a surge in severe adenovirus infections, leading to concerns about the impact of eased public health restrictions and immune debt in children under five years old.Objective. To describe the clinical characteristics of patients with severe adenovirus infection in a pediatric hospital in Colombia.Materials and methods. We reviewed the data of 227 patients with severe adenovirus infection at the Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia.Results. A total of 196 patients were included in this study. The median age was two years, and 62% were male. Adenoviruses were isolated from all patients\u2019 samples. Ninetyseven percent were admitted to the pediatric intensive care unit, 94% required respiratory support, and the in-hospital lethality rate was 11%.Conclusion. In 2022, there was an outbreak of severe adenovirus infections, affecting mainly children under five years of age, with higher-than-usual mortality.<\/jats:p>","DOI":"10.7705\/biomedica.7047","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T15:23:00Z","timestamp":1713280980000},"page":"108-112","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Severe adenovirus infection outbreak in Colombia: Experience from a tertiary pediatric hospital in 2022","Brote de adenovirus grave en Colombia: experiencia de un hospital pedi\u00e1trico de tercer nivel en 2022"],"prefix":"10.7705","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-3679","authenticated-orcid":false,"given":"Natalia","family":"V\u00e9lez-Tirado","sequence":"first","affiliation":[{"name":"Departamento de Inmunolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"},{"name":"Departamento de Inmunolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-8401","authenticated-orcid":false,"given":"Lina","family":"Casta\u00f1o-Jaramillo","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"},{"name":"Departamento de Inmunolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3870-4102","authenticated-orcid":false,"given":"Sonia","family":"Restrepo-Gualteros","sequence":"additional","affiliation":[{"name":"Departamento de Neumolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia;\u00a0Departamento de Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia"},{"name":"Departamento de Neumolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia;\u00a0Departamento de Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-486X","authenticated-orcid":false,"given":"Catalina","family":"Alcal\u00e1-Lozano","sequence":"additional","affiliation":[{"name":"Departamento de Cuidado Intensivo Pedi\u00e1trico, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"},{"name":"Departamento de Cuidado Intensivo Pedi\u00e1trico, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0142-0519","authenticated-orcid":false,"given":"Erika","family":"Ruge","sequence":"additional","affiliation":[{"name":"Departamento de Cuidado Intensivo Pedi\u00e1trico, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"},{"name":"Departamento de Cuidado Intensivo Pedi\u00e1trico, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Puente","sequence":"additional","affiliation":[{"name":"Departamento de Cuidado Intensivo Pedi\u00e1trico, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"},{"name":"Departamento de Cuidado Intensivo Pedi\u00e1trico, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8562-4960","authenticated-orcid":false,"given":"Diana","family":"Li-Zeng","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia"},{"name":"Departamento de Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-9191","authenticated-orcid":false,"given":"Diego","family":"Chaparro-Arce","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda, Universidad El Bosque, Bogot\u00e1, D.C., Colombia"},{"name":"Departamento de Pediatr\u00eda, Universidad El Bosque, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Camila","family":"Beltr\u00e1n-Dimas","sequence":"additional","affiliation":[{"name":"Departamento de Cuidado Intensivo Pedi\u00e1trico, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"},{"name":"Departamento de Cuidado Intensivo Pedi\u00e1trico, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3175-1651","authenticated-orcid":false,"given":"Juan Francisco","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, Colombia"},{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-3137","authenticated-orcid":false,"given":"Miguel","family":"Luengas-Monroy","sequence":"additional","affiliation":[{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, Colombia"},{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-2311","authenticated-orcid":false,"given":"Diego","family":"Galvis-Trujillo","sequence":"additional","affiliation":[{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, Colombia"},{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Guti\u00e9rrez-Tobar","sequence":"additional","affiliation":[{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Cl\u00ednica Infantil Colsubsidio, Bogot\u00e1, D.C., Colombia;\u00a0Departamento de Infectolog\u00eda Pedi\u00e1trica, Cl\u00ednica Infantil Santa Mar\u00eda del Lago, Bogot\u00e1, D.C., Colombia"},{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Cl\u00ednica Infantil Colsubsidio, Bogot\u00e1, D.C., Colombia;\u00a0Departamento de Infectolog\u00eda Pedi\u00e1trica, Cl\u00ednica Infantil Santa Mar\u00eda del Lago, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-5032","authenticated-orcid":false,"given":"Pablo","family":"V\u00e1squez-Hoyos","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia; Departamento de Pediatr\u00eda, Fundaci\u00f3n Universitaria de Ciencias de la Salud, Bogot\u00e1, Colombia"},{"name":"Departamento de Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia; Departamento de Pediatr\u00eda, Fundaci\u00f3n Universitaria de Ciencias de la Salud, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0472-798X","authenticated-orcid":false,"given":"Germ\u00e1n","family":"Camacho-Moreno","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia; Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, Bogot\u00e1, Colombia"},{"name":"Departamento de Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia; Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico La Misericordia, 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Adenovirus respiratory infections post pandemic in Colombia: An old enemy with increased severity in pediatric population? Pediatr Infect Dis J. 2023;42:e133-4. https:\/\/doi.org\/10.1097\/INF.0000000000003827","DOI":"10.1097\/INF.0000000000003827"},{"key":"132252","doi-asserted-by":"crossref","unstructured":"Shi T, Chen C, Fan H, Yu M, Li M, Yang D, et al. Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia. BMC Pulm Med. 2023;23:41. https:\/\/doi.org\/10.1186\/s12890-022-02284-5","DOI":"10.1186\/s12890-022-02284-5"},{"key":"132253","doi-asserted-by":"crossref","unstructured":"Cohen R, Levy C, Rybak A, Angoulvant F, Ouldali N, Grimprel E. Immune debt: Recrudescence of disease and confirmation of a contested concept. Infect Dis Now. 2023;53:104638. https:\/\/doi.org\/10.1016\/j.idnow.2022.12.003","DOI":"10.1016\/j.idnow.2022.12.003"},{"key":"132254","unstructured":"Rodr\u00edguez C, Rodr\u00edguez AD, C\u00e1rdenas A, Quilaguy I, Mayorga L, Falla L, et al. Infecci\u00f3n por virus sincitial respiratorio y por adenovirus en una poblaci\u00f3n de ni\u00f1os colombianos menores de 3 a\u00f1os hospitalizados por infecci\u00f3n respiratoria aguda baja. Revista M\u00e9dica Sanitas. 2013;16:68-76."},{"key":"132255","doi-asserted-by":"crossref","unstructured":"Herrera D, De la Hoz F, Mari\u00f1o C, Ram\u00edrez E, L\u00f3pez J, V\u00e9lez C. Adenovirus en ni\u00f1os menores de cinco a\u00f1os. Patrones de circulaci\u00f3n, caracter\u00edsticas cl\u00ednicas y epidemiol\u00f3gicas en Colombia, 1997-2003. Revista de Salud P\u00fablica. 2007;9:420-9.","DOI":"10.1590\/S0124-00642007000300010"}],"container-title":["Biom\u00e9dica"],"original-title":[],"link":[{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7047\/5447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7047\/5576","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7047\/5447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:15:38Z","timestamp":1773324938000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/view\/7047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,31]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,3,31]]}},"URL":"https:\/\/doi.org\/10.7705\/biomedica.7047","relation":{},"ISSN":["2590-7379","0120-4157"],"issn-type":[{"value":"2590-7379","type":"electronic"},{"value":"0120-4157","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,31]]},"assertion":[{"value":"2024-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer Reviewed","group":{"name":"peer_review","label":"Peer Review"}},{"value":"Instituto Nacional de Salud","name":"publisher","label":"This article is maintained by"},{"value":"Biomedica","name":"journaltitle","label":"Journal Title"},{"value":"Comunicaci\u00f3n breve","name":"content_type","label":"Content Type"}]}}