{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:38:21Z","timestamp":1787981901212,"version":"build-2784847793"},"reference-count":29,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"2","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introducci\u00f3n. Mycobacterium chelonae y los complejos Mycobacterium avium y M. abscessus, son agentes pat\u00f3genos emergentes causantes de micobacteriosis. El tratamiento de esta infecci\u00f3n depende de la especie y la subespecie identificadas. Los f\u00e1rmacos de elecci\u00f3n son los macr\u00f3lidos y aminogluc\u00f3sidos, contra los cuales se ha reportado resistencia; por esta raz\u00f3n, el determinar el perfil de sensibilidad le permite al m\u00e9dico tratante comprender mejor el pron\u00f3stico y la evoluci\u00f3n de estas infecciones.Objetivo. Describir los perfiles de sensibilidad ante macr\u00f3lidos y aminogluc\u00f3sidos, de los cultivos identificados como complejo Mycobacterium avium, complejo M. abscessus o especie M. chelonae, en el Laboratorio Nacional de Referencia de Micobacterias durante los a\u00f1os 2018 a 2022.Materiales y m\u00e9todos. Se llev\u00f3 a cabo un estudio descriptivo del perfil de sensibilidad a macr\u00f3lidos y aminogluc\u00f3sidos, de los cultivos identificados como complejo M. avium, complejo M. abscessus o M. chelonae, mediante la metodolog\u00eda GenoType\u00ae NTM-DR.Resultados. Los cultivos del complejo M. avium fueron 159 (47,3 %), de los cuales, 154 (96,9 %) fueron sensibles y 5 (3,1 %) resistentes a los macr\u00f3lidos; todos fueron sensibles a los aminogluc\u00f3sidos. Del complejo M. abscessus se estudiaron 125 (37,2 %) cultivos, 68 (54,4 %) resultaron sensibles y 57 (45,6 %) resistentes a los macr\u00f3lidos; solo un cultivo (0,8 %) fue resistente a los aminogluc\u00f3sidos. De M. chelonae se analizaron 52 cultivos (15,5 %), todos sensibles a los macr\u00f3lidos y aminogluc\u00f3sidos.Conclusiones. En las tres especies de micobacterias estudiadas, la resistencia contra la amikacina fue la menos frecuente. La identificaci\u00f3n de las subespecies y los perfiles de sensibilidad permiten instaurar esquemas de tratamiento adecuados, especialmente en las micobacteriosis causadas por M. abscessus.<\/jats:p>","DOI":"10.7705\/biomedica.7197","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:00:55Z","timestamp":1722423655000},"page":"182-190","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Prevalencia de la resistencia a macr\u00f3lidos y aminogluc\u00f3sidos en los complejos Mycobacterium avium y M. abscessus y en Mycobacterium chelonae identificados en el Laboratorio Nacional de Referencia de Colombia entre el 2018 y el 2022","Prevalence of resistance to macrolides and aminoglycosides in Mycobacterium avium, M. abscessus, and M. chelonae identified in the Laboratorio Nacional de Referencia of Colombia from 2018 to 2022"],"prefix":"10.7705","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7309-1247","authenticated-orcid":false,"given":"Claudia","family":"Llerena","sequence":"first","affiliation":[{"name":"Grupo de Micobacterias, Laboratorio Nacional de Referencia, Instituto Nacional de Salud, Bogot\u00e1, D.C., Colombia"},{"name":"Grupo de Micobacterias, Laboratorio Nacional de Referencia, Instituto Nacional de Salud, Bogot\u00e1, D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2323-9394","authenticated-orcid":false,"given":"Yanely Ang\u00e9lica","family":"Valbuena","sequence":"additional","affiliation":[{"name":"Grupo de Micobacterias, Laboratorio Nacional de Referencia, Instituto Nacional de Salud, Bogot\u00e1, D.C., Colombia"},{"name":"Grupo de Micobacterias, Laboratorio Nacional de Referencia, Instituto Nacional de Salud, Bogot\u00e1, D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7144-6507","authenticated-orcid":false,"given":"Angie Paola","family":"Zabaleta","sequence":"additional","affiliation":[{"name":"Grupo de Micobacterias, Laboratorio Nacional de Referencia, Instituto Nacional de Salud, Bogot\u00e1, D.C., Colombia"},{"name":"Grupo de Micobacterias, Laboratorio Nacional de Referencia, Instituto Nacional de Salud, Bogot\u00e1, D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3618-7902","authenticated-orcid":false,"given":"Ang\u00e9lica Nathalia","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Grupo de Micobacterias, Laboratorio Nacional de Referencia, Instituto Nacional de Salud, Bogot\u00e1, D.C., Colombia"},{"name":"Grupo de Micobacterias, Laboratorio Nacional de Referencia, Instituto Nacional de Salud, Bogot\u00e1, D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"133872","doi-asserted-by":"crossref","unstructured":"Falkinham J. 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