{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:43:18Z","timestamp":1792489398951,"version":"4.5.0"},"reference-count":31,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"4","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introducci\u00f3n. La toxoplasmosis cong\u00e9nita es una enfermedad parasitaria de importante prevalencia a nivel mundial, con gran morbilidad y afectaci\u00f3n del neurodesarrollo en pacientes pedi\u00e1tricos.Objetivo. Describir las secuelas y valorar el neurodesarrollo de pacientes pedi\u00e1tricos con toxoplasmosis cong\u00e9nita en el Hospital Militar Central del 2013 al 2020.Materiales y m\u00e9todos. Se trata de un estudio observacional, descriptivo y de corte transversal, con componente anal\u00edtico, que incluy\u00f3 los pacientes pedi\u00e1tricos con diagn\u00f3stico de toxoplasmosis cong\u00e9nita que consultaron al Hospital Militar Central durante el periodo de enero de 2013 a diciembre de 2020. En los ni\u00f1os menores de seis a\u00f1os, se utiliz\u00f3 la escala de neurodesarrollo Ages and Stages Questionnaires 3.Resultados. Se incluyeron 45 pacientes con toxoplasmosis cong\u00e9nita confirmada, con una media de edad de 5,9 a\u00f1os; 60 % eran de sexo masculino. El 11,2 % estaban sintom\u00e1ticos al nacer y el 33 % present\u00f3 coriorretinitis. Durante el seguimiento, el 73 % present\u00f3 secuelas oftalmol\u00f3gicas; el 64 %, ten\u00eda calcificaciones en la tomograf\u00eda computarizada; el 4,4 %, hidrocefalia; el 11,2 %, par\u00e1lisis cerebral, y el 13,4 %, epilepsia focal. El 58 % de los menores de seis a\u00f1os present\u00f3 compromiso del neurodesarrollo y el 62 % de los mayores de seis a\u00f1os ten\u00eda d\u00e9ficit cognitivo. En esta cohorte, el 68 % de los pacientes recibi\u00f3 tratamiento posnatal. Se obtuvo una asociaci\u00f3n estad\u00edsticamente significativa entre no recibir tratamiento y las secuelas oftalmol\u00f3gicas (OR = 5,2; p &lt; 0,001).Conclusiones. La toxoplasmosis cong\u00e9nita se asoci\u00f3 con secuelas a largo plazo, similares a las descritas en otras series de casos latinoamericanos. Es de suma importancia hacer un diagn\u00f3stico temprano, con evaluaci\u00f3n, tratamiento y seguimiento interdisciplinario oportunos en los pacientes colombianos para mejorar su pron\u00f3stico.<\/jats:p>","DOI":"10.7705\/biomedica.7206","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T10:50:06Z","timestamp":1731063006000},"page":"496-509","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Secuelas cl\u00ednicas y neurodesarrollo de pacientes pedi\u00e1tricos con toxoplasmosis cong\u00e9nita en un centro de cuarto nivel","Clinical outcomes of pediatric patients with congenital toxoplasmosis in a fourthlevel center Introduction. Congenital"],"prefix":"10.7705","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8390-7973","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Posada-Bustos","sequence":"first","affiliation":[{"name":"Servicio de Neurolog\u00eda Pedi\u00e1trica, Hospital Militar Central, Facultad de Medicina, Universidad Militar Nueva Granada, Bogot\u00e1, D. C., Colombia"},{"name":"Servicio de Neurolog\u00eda Pedi\u00e1trica, Hospital Militar Central, Facultad de Medicina, Universidad Militar Nueva Granada, Bogot\u00e1, D. C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-5919","authenticated-orcid":false,"given":"Ana Cristina","family":"Mari\u00f1o","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda Pedi\u00e1trica, Hospital Militar Central, Facultad de Medicina, Universidad Militar Nueva Granada, Bogot\u00e1, D. C., Colombia"},{"name":"Servicio de Infectolog\u00eda Pedi\u00e1trica, Hospital Militar Central, Facultad de Medicina, Universidad Militar Nueva Granada, Bogot\u00e1, D. C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-6475","authenticated-orcid":false,"given":"Eugenia","family":"Espinosa-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda Pedi\u00e1trica, Hospital Militar Central, Facultad de Medicina, Universidad Militar Nueva Granada, Bogot\u00e1, D. C., Colombia"},{"name":"Servicio de Infectolog\u00eda Pedi\u00e1trica, Hospital Militar Central, Facultad de Medicina, Universidad Militar Nueva Granada, Bogot\u00e1, D. C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"140353","doi-asserted-by":"crossref","unstructured":"Dubey JP. Sources of Toxoplasma gondii infection in pregnancy. Until rates of congenital toxoplasmosis fall, control measures are essential. BMJ. 2000;321:127-8. https:\/\/doi.org\/10.1136\/bmj.321.7254.127","DOI":"10.1136\/bmj.321.7254.127"},{"key":"140354","doi-asserted-by":"crossref","unstructured":"Khan K, Khan W. Congenital toxoplasmosis: An overview of the neurological and ocular manifestations. Parasitol Int. 2018;67:715-21. https:\/\/doi.org\/10.1016\/j.parint.2018.07.004","DOI":"10.1016\/j.parint.2018.07.004"},{"key":"140355","doi-asserted-by":"crossref","unstructured":"Maldonado YA, Read JS; Committee on Infectious Diseases. Diagnosis, treatment, and prevention of congenital toxoplasmosis in the United States. Pediatrics. 2017;139:e20163860. https:\/\/doi.org\/10.1542\/peds.2016-3860","DOI":"10.1542\/peds.2016-3860"},{"key":"140356","doi-asserted-by":"crossref","unstructured":"Gilbert R. Epidemiology of infection in pregnant women. In: Ambroise-Thomas P, Petersen E, editors. Congenital toxoplasmosis. Scientific background, clinical management and control. Paris: Springer-Verlag; 2000. p. 237-49.","DOI":"10.1007\/978-2-8178-0847-5_18"},{"key":"140357","doi-asserted-by":"crossref","unstructured":"Ca\u00f1\u00f3n-Franco WA, L\u00f3pez-Orozco N, G\u00f3mez-Mar\u00edn JE, Dubey JP. An overview of seventy years of research (1944-2014) on toxoplasmosis in Colombia, South America. Parasit Vectors. 2014;4;7:427. https:\/\/doi.org\/10.1186\/1756-3305-7-427","DOI":"10.1186\/1756-3305-7-427"},{"key":"140358","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Grisales LJ, Cruz-Moncada M, Pel\u00e1ez-S\u00e1nchez RG, D\u00edaz-Nieto JF. Toxoplasma gondii infection in Colombia with a review of hosts and their ecogeographic distribution. Zoonoses Public Health. 2021;68:38-53. https:\/\/doi.org\/10.1111\/zph.12787","DOI":"10.1111\/zph.12787"},{"key":"140359","doi-asserted-by":"crossref","unstructured":"Cort\u00e9s JA, G\u00f3mez JE, Silva PI, Ar\u00e9valo L, Ar\u00e9valo-Rodr\u00edguez I, \u00c1lvarez MI, et al. Gu\u00eda de atenci\u00f3n integral para la prevenci\u00f3n, detecci\u00f3n temprana y tratamiento de las complicaciones del embarazo, parto y puerperio: secci\u00f3n toxoplasmosis en el embarazo. Infectio. 2012;16:230-46. https:\/\/doi.org\/10.22354\/in.v21i2","DOI":"10.1016\/S0123-9392(12)70018-8"},{"key":"140360","doi-asserted-by":"crossref","unstructured":"Squires J, Bricker D. Ages & Stages Questionnaires. Third edition. (ASQ-3): A parent-completed child- monitoring system. 2009. Stanford: Paul Brookes Publishing Company. 2009. p. 1-191.","DOI":"10.1037\/t11523-000"},{"key":"140361","doi-asserted-by":"crossref","unstructured":"Singh A, Yeh CJ, Boone-Blanchard S. Ages and stages questionnaire: A global screening scale. Bol Med Hosp Infant Mex. 2017;74:5-12. https:\/\/doi.org\/10.1016\/j.bmhimx.2016.07.008","DOI":"10.1016\/j.bmhimx.2016.07.008"},{"key":"140362","doi-asserted-by":"crossref","unstructured":"Chqnhaut BL, Armijo RI. Aplicabilidad del Ages & Stages Questionnaires para el tamizaje del desarrollo psicomotor. Rev Chil Pediatr. 2014;85:12-21. https:\/\/doi.org\/10.4067\/S0370-41062014000100002","DOI":"10.4067\/S0370-41062014000100002"},{"key":"140363","unstructured":"G\u00f3mez-Mar\u00edn JE. Evaluaci\u00f3n del tratamiento de la toxoplasmosis gestacional en una cohorte colombiana. Infectio. 2005;9:16-23."},{"key":"140364","unstructured":"G\u00f3mez-Mar\u00edn JE, Casta\u00f1o JC, Montoya-Londo\u00f1o MT, Loango N, L\u00f3pez C, Sarmiento MC, et al. Toxoplasmosis cong\u00e9nita en Colombia: an\u00e1lisis cl\u00ednico y de laboratorio en 27 casos. Pediatr\u00eda. 2000;35:52-7."},{"key":"140365","doi-asserted-by":"crossref","unstructured":"Mej\u00eda-Oquendo M, Marulanda-Ibarra E, G\u00f3mez-Mar\u00edn JE. Evaluation of the impact of the first evidence-based guidelines for congenital toxoplasmosis in Armenia (Quind\u00edo) Colombia: An observational retrospective analysis. Lancet Reg Health Am. 2021;1:100010. https:\/\/doi.org\/doi:10.1016\/j.lana.2021.100010","DOI":"10.1016\/j.lana.2021.100010"},{"key":"140366","unstructured":"Neto EC, Amorim F, Lago EG. Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screening. Sci Med. 2010;20:64-70."},{"key":"140367","doi-asserted-by":"crossref","unstructured":"Dubey JP, Lago EG, Gennari SM, Su C, Jones JL. Toxoplasmosis in humans and animals in Brazil: High prevalence, high burden of disease, and epidemiology. Parasitology. 2012;139:1375-424. https:\/\/doi.org\/10.1017\/S0031182012000765","DOI":"10.1017\/S0031182012000765"},{"key":"140368","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Mar\u00edn JE, de-la-Torre A, \u00c1ngel-Muller E, Rubio J, Arenas J, Osorio E, et al. First Colombian multicentric newborn screening for congenital toxoplasmosis. PLoS Negl Trop Dis. 2011;5:e1195. https:\/\/doi.org\/10.1371\/journal.pntd.0001195","DOI":"10.1371\/journal.pntd.0001195"},{"key":"140369","doi-asserted-by":"crossref","unstructured":"Jones JL, Muccioli C, Belfort R Jr, Holland GN, Roberts JM, Silveira C. Recently acquired Toxoplasma gondii infection, Brazil. Emerg Infect Dis. 2006;12:582-6. https:\/\/doi.org\/10.3201\/eid1204.051081","DOI":"10.3201\/eid1204.051081"},{"key":"140370","doi-asserted-by":"crossref","unstructured":"Zuluaga LM, Hern\u00e1ndez JC, Casta\u00f1o CF, Donado JH. Effect of antenatal spiramycin treatment on the frequency of retinochoroiditis due to congenital toxoplasmosis in a Colombian cohort. Biom\u00e9dica. 2017;37:86-91. https:\/\/doi.org\/10.7705\/biomedica.v37i2.2818","DOI":"10.7705\/biomedica.v37i2.2818"},{"key":"140371","doi-asserted-by":"crossref","unstructured":"Bartholo BB, Monteiro DL, Rodrigues NC, Trajano AJ, Jesus N, Cardoso FF, et al. Treatment of acute toxoplasmosis in pregnancy: Influence in the mother-to-child transmission. J Obstet Gynaecol Can. 2020;42:1505-10. https:\/\/doi.org\/10.1016\/j.jogc.2020.04.021","DOI":"10.1016\/j.jogc.2020.04.021"},{"key":"140372","doi-asserted-by":"crossref","unstructured":"Cruz-Agudelo DC, Bedoya-V\u00e9lez M, Rodr\u00edguez-Padilla LM, Campo-Campo MN, San\u00edn-Blair JE, Londo\u00f1o-Montoya JA, et al. Toxoplasmosis gestacional: desenlaces obst\u00e9tricos y resultados perinatales en un hospital de referencia en Medell\u00edn, Colombia. 2015-2021. Un estudio descriptivo. Infectio. 2023;27:223-9 https:\/\/doi.org\/10.22354\/24223794.115","DOI":"10.22354\/24223794.1150"},{"key":"140373","doi-asserted-by":"crossref","unstructured":"McLeod R, Boyer K, Karrison T, Kasza K, Swisher C, Roizen N, et al. Outcome of treatment for congenital toxoplasmosis, 1981-2004: The National Collaborative Chicago-Based, Congenital Toxoplasmosis Study. Clin Infect Dis. 2006;42:1383-94. https:\/\/doi.org\/10.1086\/501360","DOI":"10.1086\/501360"},{"key":"140374","doi-asserted-by":"crossref","unstructured":"Gilbert RE, Freeman K, Lago EG, Bahia-Oliveira LM, Tan HK, Wallon M, et al. European Multicentre Study on Congenital Toxoplasmosis (EMSCOT). Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe. PLoS Negl Trop Dis. 2008;2:e277. https:\/\/doi.org\/10.1371\/journal.pntd.0000277","DOI":"10.1371\/journal.pntd.0000277"},{"key":"140375","doi-asserted-by":"crossref","unstructured":"Vasconcelos-Santos DV, Machado-Azevedo DO, Campos WR, Or\u00e9fice F, Queiroz-Andrade GM, Carellos EV, et al. UFMG Congenital Toxoplasmosis Brazilian Group. Congenital toxoplasmosis in Southeastern Brazil: Results of early ophthalmologic examination of a large cohort of neonates. Ophthalmology. 2009;116:2199-205.e1. https:\/\/doi.org\/10.1016\/j.ophtha.2009.04.042","DOI":"10.1016\/j.ophtha.2009.04.042"},{"key":"140376","doi-asserted-by":"crossref","unstructured":"Olariu TR, Remington JS, McLeod R, Alam A, Montoya JG. Severe congenital toxoplasmosis in the United States: Clinical and serologic findings in untreated infants. Pediatr Infect Dis J. 2011;30:1056-61. https:\/\/doi.org\/10.1086\/501360","DOI":"10.1097\/INF.0b013e3182343096"},{"key":"140377","doi-asserted-by":"crossref","unstructured":"Berrebi A, Assouline C, Bessi\u00e8res MH, Lathi\u00e8re M, Cassaing S, Minville V, et al. Long-term outcome of children with congenital toxoplasmosis. Am J Obstet Gynecol. 2010;203:552,e1-6. https:\/\/doi.org\/10.1016\/j.ajog.2010.06.002","DOI":"10.1016\/j.ajog.2010.06.002"},{"key":"140378","doi-asserted-by":"crossref","unstructured":"Thi\u00e9baut R, Leproust S, Ch\u00eane G, Gilbert R; SYROCOT (Systematic Review on Congenital Toxoplasmosis) Study Group. Effectiveness of prenatal treatment for congenital toxoplasmosis: A meta-analysis of individual patients\u2019 data. Lancet. 2007;369:115-22. https:\/\/doi.org\/10.1016\/S0140-6736(07)60072-5","DOI":"10.1016\/S0140-6736(07)60072-5"},{"key":"140379","doi-asserted-by":"crossref","unstructured":"Peyron F, Lobry JR, Musset K, Ferrandiz J, G\u00f3mez-Mar\u00edn JE, Petersen E, et al. Serotyping of Toxoplasma gondii in chronically infected pregnant women: Predominance of type II in Europe and types I and III in Colombia (South America). Microbes Infect. 2006;8:2333-40. https:\/\/doi.org\/10.1016\/j.micinf.2006.03.023","DOI":"10.1016\/j.micinf.2006.03.023"},{"key":"140380","doi-asserted-by":"crossref","unstructured":"Cortina-Borja M, Tan HK, Wallon M, Paul M, Prusa A, Buffolano W, et al. European Multicentre Study on Congenital Toxoplasmosis (EMSCOT). Prenatal treatment for serious neurological sequelae of congenital toxoplasmosis: An observational prospective cohort study. PLoS Med. 2010;7:e1000351. https:\/\/doi.org\/10.1371\/journal.pmed.1000351","DOI":"10.1371\/journal.pmed.1000351"},{"key":"140381","unstructured":"Roizen N, Swisher CN, Stein MA, Hopkins J, Boyer KM, Holfels E, et al. Neurologic and developmental outcome in treated congenital toxoplasmosis. Pediatrics. 1995;95:11-20."},{"key":"140382","doi-asserted-by":"crossref","unstructured":"Patel DV, Holfels EM, Vogel NP, Boyer KM, Mets MB, Swisher CN, et al. Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis. Radiology. 1996;199:433-40. https:\/\/doi.org\/10.1148\/radiology.199.2.8668790","DOI":"10.1148\/radiology.199.2.8668790"},{"key":"140383","doi-asserted-by":"crossref","unstructured":"Phan L, Kasza K, Jalbrzikowski J, Noble AG, Latkany P, Kuo A, et al. Toxoplasmosis Study Group. Longitudinal study of new eye lesions in treated congenital toxoplasmosis. Ophthalmology. 2008;115:553-9. https:\/\/doi.org\/10.1016\/j.ophtha.2007.06.022","DOI":"10.1016\/j.ophtha.2007.06.022"}],"container-title":["Biom\u00e9dica"],"original-title":[],"link":[{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7206\/5555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7206\/5700","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7206\/5555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:15:37Z","timestamp":1773321337000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/view\/7206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,11,6]]}},"URL":"https:\/\/doi.org\/10.7705\/biomedica.7206","relation":{},"ISSN":["2590-7379","0120-4157"],"issn-type":[{"value":"2590-7379","type":"electronic"},{"value":"0120-4157","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,6]]},"assertion":[{"value":"2024-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer Reviewed","group":{"name":"peer_review","label":"Peer Review"}},{"value":"Instituto Nacional de Salud","name":"publisher","label":"This article is maintained by"},{"value":"Biomedica","name":"journaltitle","label":"Journal Title"},{"value":"Art\u00edculos originales","name":"content_type","label":"Content Type"}]}}