{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:34:39Z","timestamp":1781789679951,"version":"3.54.5"},"reference-count":23,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"4","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Creutzfeldt-Jakob disease is a rare neurodegenerative disease caused by prions.We present the case of a woman in the seventh decade of life with rapidly progressive dementia and myoclonus. Her brain magnetic resonance imaging revealed lesions in the basal nuclei, and the electroencephalogram showed periodic bilateral epileptiform discharges.In the cerebrospinal fluid, the prion protein was detected using the real-time quaking-induced conversion test (RT-QuIC), and elevated levels of tau and 14-3-3 proteins. We emphasize the significance of determining the prion protein in the definitive diagnosis of this disease.<\/jats:p>","DOI":"10.7705\/biomedica.7352","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T10:50:06Z","timestamp":1731063006000},"page":"434-440","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Determination of prion proteins in the diagnosis of Creutzfeldt-Jakob disease using RT-QuIC: A case report from northeastern Colombia","Determinaci\u00f3n de priones en el diagn\u00f3stico de la enfermedad de Creutzfeldt-Jakob: un reporte de caso en el nororiente colombiano"],"prefix":"10.7705","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4062-147X","authenticated-orcid":false,"given":"Jairo","family":"Lizarazo","sequence":"first","affiliation":[{"name":"Departamento de Medicina Interna, Universidad de Pamplona, Hospital Universitario Erasmo"},{"name":"Departamento de Medicina Interna, Universidad de Pamplona, Hospital Universitario Erasmo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3173-2752","authenticated-orcid":false,"given":"Aixa Xiomara","family":"Vargas","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Universidad de Pamplona, Hospital Universitario Erasmo"},{"name":"Departamento de Medicina Interna, Universidad de Pamplona, Hospital Universitario Erasmo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6013-4973","authenticated-orcid":false,"given":"Rafael","family":"Olarte","sequence":"additional","affiliation":[{"name":"Unidad de Epidemiolog\u00eda, Hospital Universitario Erasmo Meoz, C\u00facuta, Colombia Meoz, C\u00facuta, Colombia"},{"name":"Unidad de Epidemiolog\u00eda, Hospital Universitario Erasmo Meoz, C\u00facuta, Colombia Meoz, C\u00facuta, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0574-6907","authenticated-orcid":false,"given":"David Andr\u00e9s","family":"Lizarazo","sequence":"additional","affiliation":[{"name":"Departmento de Radiolog\u00eda, Hospital Central de la Polic\u00eda, Bogot\u00e1, D. C., Colombia"},{"name":"Departmento de Radiolog\u00eda, Hospital Central de la Polic\u00eda, Bogot\u00e1, D. C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"140087","doi-asserted-by":"crossref","unstructured":"Geschwind MD. Prion Diseases. Continuum (Minneap Minn). 2015;21:1612-38. https:\/\/doi.org\/10.1212\/CON.0000000000000251","DOI":"10.1212\/CON.0000000000000251"},{"key":"140088","doi-asserted-by":"crossref","unstructured":"Hermann P, Appleby B, Brandel JP, Caughey B, Collins S, Geschwind MD, et al. Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease. Lancet Neurol. 2021;20:235-46. https:\/\/doi.org\/10.1016\/S1474-4422(20)30477-4","DOI":"10.1016\/S1474-4422(20)30477-4"},{"key":"140089","unstructured":"European Centre for Disease Prevention and Control. Laboratory standard operating procedure for detecting sporadic Creuzfeldt-Jakob disease using Real-Time Quaking-Induced Conversion (RT-QuIC) assay. Stockholm: ECDC; 2021."},{"key":"140090","unstructured":"Centers for Disease Control and Prevention - CDC. Diagnostic criteria for Creutzfeldt-Jakob Disease (CJD), 2018. Accessed: December 14, 2023. Available at: https:\/\/www.cdc.gov\/prions\/cjd\/diagnostic-criteria.html#print"},{"key":"140091","doi-asserted-by":"crossref","unstructured":"Fiorini M, Iselle G, Perra D, Bongianni M, Capaldi S, Sacchetto L, et al. High diagnostic accuracy of RT-QuIC assay in a prospective study of patients with suspected sCJD. Int J Mol Sci. 2020;21:880. https:\/\/doi.org\/10.3390\/ijms21030880","DOI":"10.3390\/ijms21030880"},{"key":"140092","doi-asserted-by":"crossref","unstructured":"Chatzikonstantinou S, Kazis D, Karantali E, Knights M, McKenna J, Petridis F, et al. A metaanalysis on RT-QuIC for the diagnosis of sporadic CJD. Acta Neurol Belg. 2021;121:341-49. https:\/\/doi.org\/10.1007\/s13760-021-01596-3","DOI":"10.1007\/s13760-021-01596-3"},{"key":"140093","doi-asserted-by":"crossref","unstructured":"Green AJE. RT-QuIC: A new test for sporadic CJD. Pract Neurol. 2019;19:49-55. https:\/\/doi.org\/10.1136\/practneurol-2018-001935","DOI":"10.1136\/practneurol-2018-001935"},{"key":"140094","doi-asserted-by":"crossref","unstructured":"Escand\u00f3n-Vargas K, Zorrilla-Vaca A, Corral-Prado RH. Prote\u00ednas 14-3-3 y tau positivas en un caso de enfermedad espor\u00e1dica de Creutzfeldt-Jakob y una breve rese\u00f1a de las enfermedades pri\u00f3nicas en Colombia. Biom\u00e9dica. 2016;36:29-36. https:\/\/doi.org\/10.7705\/biomedica.v36i3.2729.","DOI":"10.7705\/biomedica.v36i3.2729"},{"key":"140095","unstructured":"Paredes A, Castro A, Toro G, Parra E. Vigilancia epidemiol\u00f3gica de enfermedades pri\u00f3nicas en Colombia, 2005 a 2012. IQEN 2013;18:32-41."},{"key":"140096","unstructured":"Mantilla YF, Mu\u00f1oz MA, P\u00e9rez CE, Rodr\u00edguez I, Ca\u00f1\u00f3n S, Tuta EA. Enfermedad de Creutzfeldt-Jakob. Presentaci\u00f3n de un caso y revisi\u00f3n de la literatura. Rev Med. 2019;27. https:\/\/revistas.unimilitar.edu.co\/index.php\/rmed\/article\/view\/3759"},{"key":"140097","doi-asserted-by":"crossref","unstructured":"Vallejo DE, Molina SM, Erazo MM. Abordaje paliativo domiciliario: delirium refractario en enfermedad de Creutzfeldt-Jakob. Reporte de caso. Rev Med Sanitas. 2021:24: 29-34. https:\/\/doi.org\/10.26852\/01234250.451","DOI":"10.26852\/01234250.451"},{"key":"140098","doi-asserted-by":"crossref","unstructured":"L\u00f3pez SL, Restrepo F, Moreno LF, Delgado A, Vidal MA. Aporte de la 18F-FDG PET\/TC en la enfermedad de Creutzfeldt-Jakob espor\u00e1dica. 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