{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:00:29Z","timestamp":1787032829503,"version":"build-2736575974"},"reference-count":25,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"2","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Malaria is a tropical disease that is rarely reported in liver transplant recipients. However, some cases have been documented around the world and here we report two. Case 1. A 54-year-old male attended the emergency room 30 days after liver transplantation due to malaise, fever, chills, thrombocytopenia, and anemia. Plasmodium vivax was detected in the blood smear, and the patient was treated with artemether\/lumefantrine, achieving resolution of the parasitemia. Neither chloroquine nor primaquine were prescribed because they were unavailable in the country. Two months later, the patient returned to the emergency room with the same symptoms and was diagnosed with a relapse of malaria caused by P. vivax. The patient received successful treatment with chloroquine and primaquine, which were already available. Given that the liver donor came from a malaria-endemic area, the infection was probably of donor origin, likely by hypnozoites present in the allograft.Case 2. A 58-year-old woman living in a malaria-endemic region attended the emergency service with fever, malaise, arthralgia, cytopenias, and hypertransaminasemia six months after undergoing a liver transplant. P. vivax was detected in the blood smear, so treatment with chloroquine and primaquine was started. After treatment, the blood smear was negative, and the patient was discharged.<\/jats:p>","DOI":"10.7705\/biomedica.7433","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T10:31:13Z","timestamp":1749033073000},"page":"180-189","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Malaria after liver transplantation: Report of two cases and a review of published cases","Malaria despu\u00e9s de trasplante hep\u00e1tico: reporte de dos casos y revisi\u00f3n de los casos publicados"],"prefix":"10.7705","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3909-4230","authenticated-orcid":false,"given":"Andr\u00e9s Fernando","family":"Rodr\u00edguez-Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Grupo de Gastrohepatolog\u00eda, Universidad de Antioquia, Medell\u00edn, Colombia"},{"name":"Grupo de Gastrohepatolog\u00eda, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4698-1871","authenticated-orcid":false,"given":"Isabel Cristina","family":"Ram\u00edrez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Universidad de Antioquia, Medell\u00edn, Colombia;\u00a0Servicio de Infectolog\u00eda, Hospital Pablo Tob\u00f3n Uribe, Medell\u00edn, Colombia"},{"name":"Departamento de Medicina Interna, Universidad de Antioquia, Medell\u00edn, Colombia;\u00a0Servicio de Infectolog\u00eda, Hospital Pablo Tob\u00f3n Uribe, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"147692","unstructured":"1. Dababneh Y, Mousa OY. Liver Transplantation. Electronic edition. StatPearls Publishing; 2023. Accessed: October 15, 2023. Available at: https:\/\/pubmed.ncbi.nlm.nih.gov\/32644587\/"},{"key":"147693","doi-asserted-by":"crossref","unstructured":"2. Clemente WT, Pierrotti LC, Abdala E, Morris MI, Azevedo LS, L\u00f3pez-V\u00e9lez R, et al. Recommendations for management of endemic diseases and travel medicine in solid-organ transplant recipients and donors: Latin America. Transplantation. 2018;102:193-208. https:\/\/doi.org\/10.1097\/TP.0000000000002027","DOI":"10.1097\/TP.0000000000002027"},{"key":"147694","doi-asserted-by":"crossref","unstructured":"3. Dvorin JD, Goldberg DE. Plasmodium egress across the parasite life cycle. Annu Rev Microbiol. 2022;76:67-90. https:\/\/doi.org\/10.1146\/annurev-micro-041320-020659","DOI":"10.1146\/annurev-micro-041320-020659"},{"key":"147695","doi-asserted-by":"crossref","unstructured":"4. Sato S. Plasmodium - A brief introduction to the parasites causing human malaria and their basic biology. J Physiol Anthropol. 2021;40:1. https:\/\/doi.org\/10.1186\/s40101-020-00251-9","DOI":"10.1186\/s40101-020-00251-9"},{"key":"147696","unstructured":"5. World Health Organization. World malaria report 2022. Accessed: October 15, 2023. Available at: https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malariareport-2022"},{"key":"147697","doi-asserted-by":"crossref","unstructured":"6. Silva JT, Fern\u00e1ndez-Ruiz M, Grossi PA, Hern\u00e1ndez-Jim\u00e9nez P, L\u00f3pez-Medrano F, Mularoni A, et al. Reactivation of latent infections in solid organ transplant recipients from sub-Saharan Africa: What should be remembered? Transplant Rev. 2021;35:100632. https:\/\/doi.org\/10.1016\/j.trre.2021.100632","DOI":"10.1016\/j.trre.2021.100632"},{"key":"147698","doi-asserted-by":"crossref","unstructured":"7. Chattopadhyay R, Majam VF, Kumar S. 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Transplantation. 2003;75:166-8. https:\/\/doi.org\/10.1097\/00007890-200301150-00031","DOI":"10.1097\/00007890-200301150-00031"},{"key":"147702","unstructured":"11. Pandey D, Lee KH, Wong SY, Tan KC. Malaria after living donor liver transplantation: Report of two cases. Hepatobiliary Pancreat Dis Int. 2008;7:210-3."},{"key":"147703","unstructured":"12. Crafa F, Gugenheim J, Fabiani P, Di Marzo L, Militerno G, Iovine L, et al. Possible transmission of malaria by liver transplantation. Transplant Proc. 1991;23:2664."},{"key":"147704","unstructured":"13. Talabiska DG, Komar MJ, Wytock DH, Rubin RA. Post-transfusion acquired malaria complicating orthotopic liver transplantation. Am J Gastroenterol. 1996;91:376-9."},{"key":"147705","doi-asserted-by":"crossref","unstructured":"14. Mejia GA, \u00c1lvarez CA, Pulido HH, Ram\u00edrez B, Cardozo C, Su\u00e1rez Y, et al. Malaria in a liver transplant recipient: A case report. Transplant Proc. 2006;38:3132-4. https:\/\/doi.org\/10.1016\/j.transproceed.2006.08.187","DOI":"10.1016\/j.transproceed.2006.08.187"},{"key":"147706","doi-asserted-by":"crossref","unstructured":"15. Menichetti F, Bindi ML, Tascini C, Urbani L, Biancofiore G, Doria R, et al. Fever, mental impairment, acute anemia, and renal failure in patient undergoing orthotopic liver transplantation: Post-transplantation malaria. Liver Transpl. 2006;12:674-6. https:\/\/doi.org\/10.1002\/lt.20730","DOI":"10.1002\/lt.20730"},{"key":"147707","doi-asserted-by":"crossref","unstructured":"16. Rodr\u00edguez M, Tome S, Vizca\u00edno L, Fern\u00e1ndez-Castroagudin J, Otero-Anton E, Molina E, et al. Malaria infection through multiorgan donation: An update from Spain. Liver Transp. 2007;13:1302-4. https:\/\/doi.org\/10.1002\/lt.21219","DOI":"10.1002\/lt.21219"},{"key":"147708","doi-asserted-by":"crossref","unstructured":"17. Seth AK, Puri P, Chandra A, Dutta V, Naidu S, Saha A. Mixed Plasmodium falciparum and Plasmodium vivax malaria in orthotopic liver transplant recipient. Transplantation. 2009;88:288. https:\/\/doi.org\/10.1097\/TP.0b013e3181acc314","DOI":"10.1097\/TP.0b013e3181acc314"},{"key":"147709","doi-asserted-by":"crossref","unstructured":"18. Sab\u00e9 N, Gonz\u00e1lez-Costello J, Oriol I, S\u00e1nchez-Salado JC, Ortega S, Oliver E, et al. Donortransmitted malaria after heart transplant managed successfully with artesunate. Transpl Infect Dis. 2014;16:999-1002. https:\/\/doi.org\/10.1111\/tid.12299","DOI":"10.1111\/tid.12299"},{"key":"147710","doi-asserted-by":"crossref","unstructured":"19. Mart\u00edn-D\u00e1vila P, Norman F, Fort\u00fan-Abete J, P\u00edris M, Lovatti R, Rubio JM, et al. Donor-derived multiorgan transmission of mixed P. malariae and P. ovale infection: Impact of globalization on post-transplant infections. Transpl Infect Dis. 2018;20:e12938. https:\/\/doi.org\/10.1111\/tid.12938","DOI":"10.1111\/tid.12938"},{"key":"147711","doi-asserted-by":"crossref","unstructured":"20. Vita S, Gabrielli S, Fontanelli Sulekova L, De Angelis M, Alessandri F, Pugliese F, et al. Malaria in an asylum seeker paediatric liver transplant recipient: Diagnostic challenges for migrant population. J Infect Dev Ctries. 2021;15:172-8. https:\/\/doi.org\/10.3855\/jidc.12541","DOI":"10.3855\/jidc.12541"},{"key":"147712","doi-asserted-by":"crossref","unstructured":"21. Shaikh SW, Mahendrakar SM, Ladhani SS, Khan AH. COVID-19 and malaria co-infection management in post-liver transplant - A case report. J Clin Diagn Res. 2021;15:OD03-5. https:\/\/doi.org\/10.7860\/JCDR\/2021\/49086.14838","DOI":"10.7860\/JCDR\/2021\/49086.14838"},{"key":"147713","doi-asserted-by":"crossref","unstructured":"22. Rosso F, Agudelo Rojas OL, Su\u00e1rez Gil CC, L\u00f3pez Vargas JA, G\u00f3mez-Mesa JE, Carrillo G\u00f3mez DC, et al. Transmission of malaria from donors to solid organ transplant recipients: A case report and literature review. Transpl Infect Dis. 2021;23:e13660. https:\/\/doi.org\/10.1111\/tid.13660","DOI":"10.1111\/tid.13660"},{"key":"147714","doi-asserted-by":"crossref","unstructured":"23. Awuah WA, Ng JC, Bulut HI, Nazir A, Tenkorang PO, Yarlagadda R, et al. The unmet need of organ transplantation in Africa. Int J Surg. 2023;109:519-20. https:\/\/doi.org\/10.1097\/JS9.0000000000000025","DOI":"10.1097\/JS9.0000000000000025"},{"key":"147715","doi-asserted-by":"crossref","unstructured":"24. Requena-M\u00e9ndez A, Cattaneo P, Bogale RT, Marti-Soler H, W\u00e5ngdahl A, Buonfrate D, et al. Malaria parasite prevalence among migrants: A systematic review and meta-analysis. Clin Microbiol Infect. 2023;29:1528-37. https:\/\/doi.org\/10.1016\/j.cmi.2023.09.010","DOI":"10.1016\/j.cmi.2023.09.010"},{"key":"147716","doi-asserted-by":"crossref","unstructured":"25. Bansal SB, Ramasubramanian V, Prasad N, Saraf N, Soman R, Makharia G, et al. South Asian Transplant Infectious Disease Guidelines for Solid Organ Transplant Candidates, Recipients, and Donors. Transplantation. 2023;107:1910-34. https:\/\/doi.org\/10.1097\/TP.0000000000004521","DOI":"10.1097\/TP.0000000000004521"}],"container-title":["Biom\u00e9dica"],"original-title":[],"link":[{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7433\/5685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7433\/5828","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7433\/5685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:47:59Z","timestamp":1773319679000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/view\/7433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,5,30]]}},"URL":"https:\/\/doi.org\/10.7705\/biomedica.7433","relation":{},"ISSN":["2590-7379","0120-4157"],"issn-type":[{"value":"2590-7379","type":"electronic"},{"value":"0120-4157","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"assertion":[{"value":"2025-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer Reviewed","group":{"name":"peer_review","label":"Peer Review"}},{"value":"Instituto Nacional de Salud","name":"publisher","label":"This article is maintained by"},{"value":"Biomedica","name":"journaltitle","label":"Journal Title"},{"value":"Presentaci\u00f3n de caso","name":"content_type","label":"Content Type"}]}}