{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T01:04:22Z","timestamp":1773363862106,"version":"3.50.1"},"reference-count":29,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"1","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003402","name":"Fundaci\u00f3n Valle del Lili","doi-asserted-by":"publisher","award":["Centro de Investigaciones Cl\u00ednicas"],"award-info":[{"award-number":["Centro de Investigaciones Cl\u00ednicas"]}],"id":[{"id":"10.13039\/501100003402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003402","name":"Fundaci\u00f3n Valle del Lili","doi-asserted-by":"publisher","award":["Centro de Investigaciones Cl\u00ednicas"],"award-info":[{"award-number":["Centro de Investigaciones Cl\u00ednicas"]}],"id":[{"id":"10.13039\/501100003402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introducci\u00f3n. Las especies de Candida son el principal agente etiol\u00f3gico de infecciones f\u00fangicas en la poblaci\u00f3n pedi\u00e1trica, especialmente en neonatos y pacientes atendidos en la unidad de cuidados intensivos. La candidiasis invasiva se relaciona con desenlaces cl\u00ednicos desfavorables como tiempo de hospitalizaci\u00f3n prolongado y mortalidad.Objetivo. Describir las caracter\u00edsticas demogr\u00e1ficas, cl\u00ednicas y microbiol\u00f3gicas de los pacientes pedi\u00e1tricos (mayores de un mes y menores de 18 a\u00f1os) hospitalizados en una unidad de cuidados intensivos pedi\u00e1tricos con diagn\u00f3stico de candidiasis invasora entre el 2012 y el 2020.Materiales y m\u00e9todos. Se adelant\u00f3 un estudio observacional, retrospectivo, de tipo cohorte, en un centro de alta complejidad del suroccidente colombiano.Resultados. Se incluyeron 100 pacientes pedi\u00e1tricos con diagn\u00f3sticos de candidiasis invasora, el 51 % de sexo femenino con una mediana de edad de 6,5 a\u00f1os (RIC = 2-11,5). Se obtuvieron 114 aislamientos de Candida spp. La mediana de estancia hospitalaria fue de 51 d\u00edas (RIC = 29-77) y de estancia en la unidad de cuidados intensivos pedi\u00e1tricos de 27 d\u00edas (RIC = 16-58). El 85 % de los pacientes present\u00f3 taquicardia 24 horas antes del aislamiento de Candida spp. El 49,1 % de los aislamientos se encontr\u00f3 en las muestras de sangre (49,1 %), el lavado broncoalveolar (21,9 %) y el l\u00edquido peritoneal (20,2 %). La especie aislada m\u00e1s frecuente fue Candida albicans (36,8 %), seguida de C. parapsilosis (22,8 %) y C. tropicalis (21,1 %). El 36 % de los pacientes falleci\u00f3.Conclusiones. La candidiasis invasora es una entidad com\u00fan en las unidades de cuidados intensivos pedi\u00e1tricos y es un desaf\u00edo por su alta morbilidad, prolongaci\u00f3n de la estancia hospitalaria y tasa de mortalidad elevada. Aunque C. albicans sigue siendo la especie predominante, las especies de C. no albicans han mostrado una tendencia creciente, lo que plantea nuevos retos diagn\u00f3sticos y terap\u00e9uticos.<\/jats:p>","DOI":"10.7705\/biomedica.7444","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T09:43:45Z","timestamp":1743587025000},"page":"151-164","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Caracter\u00edsticas epidemiol\u00f3gicas de pacientes pedi\u00e1tricos con candidiasis invasora en una unidad de cuidados intensivos del suroccidente colombiano","Epidemiological characteristics of pediatric patients with invasive candidiasis in an intensive care unit in southwestern Colombia"],"prefix":"10.7705","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-3485","authenticated-orcid":false,"given":"Paola Marsela","family":"P\u00e9rez-Camacho","sequence":"first","affiliation":[{"name":"Servicio de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Valle del Lili, Cali, Colombia;\u00a0Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"},{"name":"Servicio de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Valle del Lili, Cali, Colombia;\u00a0Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7854-3982","authenticated-orcid":false,"given":"Carmen","family":"Vargas-Moran","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Valle del Lili, Cali, Colombia;\u00a0Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"},{"name":"Servicio de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Valle del Lili, Cali, Colombia;\u00a0Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2536-982X","authenticated-orcid":false,"given":"Laura","family":"Torres-Canchala","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;\u00a0Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;\u00a0Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6989-7587","authenticated-orcid":false,"given":"Camila","family":"Ariza-Insignares","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;\u00a0Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;\u00a0Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-0888","authenticated-orcid":false,"given":"Lina M.","family":"Sandoval-Calle","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-465X","authenticated-orcid":false,"given":"In\u00e9s Elvira","family":"G\u00f3mez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;\u00a0Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;\u00a0Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9379-1927","authenticated-orcid":false,"given":"Paula","family":"Sol\u00eds-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9700-1824","authenticated-orcid":false,"given":"Juliana V.","family":"Cede\u00f1o-Casta\u00f1o","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, 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World Health Organization. Children: Improving survival and well-being. 2020. Fecha de consulta: 30 de julio de 2024. Disponible en: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/children-reducing-mortality"},{"key":"145411","unstructured":"2. The Global Health Observatory. Child mortality and causes of death. Fecha de consulta: 30 de julio de 2024. Disponible en: https:\/\/www.who.int\/data\/gho\/data\/themes\/topics\/topicdetails\/GHO\/child-mortality-and-causes-of-death"},{"key":"145412","doi-asserted-by":"crossref","unstructured":"3. Cook A, Ferreras-Antolin L, Adhisivam B, Ballot D, Berkley JA, Bernaschi P, et al. Neonatal invasive candidiasis in low- and middle-income countries: Data from the NeoOBS study. Med Mycol. 2023;61:myad010. https:\/\/doi.org\/10.1093\/mmy\/myad010","DOI":"10.1093\/mmy\/myad010"},{"key":"145413","doi-asserted-by":"crossref","unstructured":"4. Bongomin F, Gago S, Oladele RO, Denning DW. 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Disponible en: https:\/\/www.enfermeriaaps.com\/portal\/download\/INFECTOLOGIA\/Protocolos%20Infectologia%20AEP%202011\/Infeccion%20fungica%20invasiva.pdf"},{"key":"145418","doi-asserted-by":"crossref","unstructured":"9. Zaoutis TE, Prasad PA, Localio AR, Coffin SE, Bell LM, Walsh TJ, et al. Risk factors and predictors for candidemia in pediatric intensive care unit patients: Implications for prevention. Clin Infect Dis. 2010;51:e38-45. https:\/\/doi.org\/10.1086\/655698","DOI":"10.1086\/655698"},{"key":"145419","doi-asserted-by":"crossref","unstructured":"10. Charsizadeh A, Mirhendi H, Nikmanesh B, Eshaghi H, Makimura K. Microbial epidemiology of candidaemia in neonatal and paediatric intensive care units at the Children\u2019s Medical Center, Tehran. Mycoses. 2018;61:22-9. https:\/\/doi.org\/10.1111\/myc.12698","DOI":"10.1111\/myc.12698"},{"key":"145420","doi-asserted-by":"crossref","unstructured":"11. Brissaud O, Guichoux J, Harambat J, Tandonnet O, Zaoutis T. Invasive fungal disease in PICU: Epidemiology and risk factors. Ann Intensive Care. 2012;2:1-8. https:\/\/doi.org\/10.1186\/2110-5820-2-6","DOI":"10.1186\/2110-5820-2-6"},{"key":"145421","doi-asserted-by":"crossref","unstructured":"12. Zaoutis T. Candidemia in children. Curr Med Res Opin. 2010;26:1761-8. https:\/\/doi.org\/10.1185\/03007995.2010.487796","DOI":"10.1185\/03007995.2010.487796"},{"key":"145422","doi-asserted-by":"crossref","unstructured":"13. Yapar N. Epidemiology and risk factors for invasive candidiasis. Ther Clin Risk Manag. 2014;10:95-105. https:\/\/doi.org\/10.2147\/TCRM.S40160","DOI":"10.2147\/TCRM.S40160"},{"key":"145423","doi-asserted-by":"crossref","unstructured":"14. Walsh TJ, Katragkou A, Chen T, Salvatore CM, Roilides E. Invasive candidiasis in infants and children: Recent advances in epidemiology, diagnosis, and treatment. J Fungi. 2019;5:11. https:\/\/doi.org\/10.3390\/jof5010011","DOI":"10.3390\/jof5010011"},{"key":"145424","doi-asserted-by":"crossref","unstructured":"15. Steinbach WJ, Roilides E, Berman D, Hoffman JA, Groll AH, Bin-Hussain I, et al. Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates. Pediatr Infect Dis J. 2012;31:1252-7. https:\/\/doi.org\/10.1097\/INF.0b013e3182737427","DOI":"10.1097\/INF.0b013e3182737427"},{"key":"145425","doi-asserted-by":"crossref","unstructured":"16. Nucci M, Queiroz-Telles F, Alvarado-Matute T, Tiraboschi IN, Cortes J, Zurita J, et al. Epidemiology of candidemia in Latin America: A laboratory-based survey. PLoS One. 2013;8:59373. https:\/\/doi.org\/10.1371\/journal.pone.0059373","DOI":"10.1371\/journal.pone.0059373"},{"key":"145426","doi-asserted-by":"crossref","unstructured":"17. Cort\u00e9s JA, Ruiz JF, Melgarejo-Moreno LN, Lemos EV. Candidemia en Colombia. Biom\u00e9dica. 2020;40:195-207. https:\/\/doi.org\/10.7705\/biomedica.4400","DOI":"10.7705\/biomedica.4400"},{"key":"145427","unstructured":"18. Rosanova MT, Sarkis C, Escarr\u00e1 F, Epelbaum C, Sberna N, Carnovale S, et al. Anidulafungina en ni\u00f1os: experiencia en ni\u00f1os con trasplante de m\u00e9dula \u00f3sea. Med Infant. 2017;24:5-7."},{"key":"145428","doi-asserted-by":"crossref","unstructured":"19. Santolaya ME, de Queiroz Telles F, Alvarado Matute T, Colombo AL, Zurita J, Tiraboschi IN, et al. Recomendaciones para el manejo de la candidemia en ni\u00f1os en Am\u00e9rica Latina. Rev Iberoam Micol. 2013;30:171-8. https:\/\/doi.org\/10.1016\/j.riam.2013.05.011","DOI":"10.1016\/j.riam.2013.05.011"},{"key":"145429","doi-asserted-by":"crossref","unstructured":"20. Jordan I, Balaguer M, L\u00f3pez-Castilla JD, Belda S, Shuffelman C, Garcia-Teresa MA, et al. 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C. albicans, C. parapsilosis, and C. tropicalis invasive infections in the PICU: Clinical features, prognosis and mortality. Rev Esp Quimioter. 2014;27:56-62."},{"key":"145437","doi-asserted-by":"crossref","unstructured":"28. Tragiannidis A, Fegeler W, Rellensmann G, Debus V, M\u00fcller V, Hoernig-Franz I, et al. Candidaemia in a European Paediatric University Hospital: A 10-year observational study. Clin Microbiol Infect. 2012;18:27-30. https:\/\/doi.org\/10.1111\/j.1469-0691.2011.03720.x","DOI":"10.1111\/j.1469-0691.2011.03720.x"},{"key":"145438","doi-asserted-by":"crossref","unstructured":"29. Pfaller MA, Diekema DJ, Gibbs DL, Newell VA, Ellis D, Tullio V, et al. Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: A 10.5-year analysis of susceptibilities of Candida species to fluconazole and voriconazole as determined by CLSI standardized disk diffusion. 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