{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T01:40:00Z","timestamp":1773366000301,"version":"3.50.1"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"Sp. 2","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Se trata de un paciente de sexo masculino de 45 a\u00f1os con tos persistente de cuatro meses de duraci\u00f3n, acompa\u00f1ada de fiebre y una significativa p\u00e9rdida de peso.En la tomograf\u00eda de t\u00f3rax, se observ\u00f3 una neumon\u00eda idiop\u00e1tica y los estudios posteriores identificaron una carga viral positiva para citomegalovirus (CMV) en el lavado broncoalveolar. La biopsia transbronquial confirm\u00f3 inclusiones bas\u00f3filas intranucleares indicativas de la infecci\u00f3n por CMV. Los valores de las inmunoglobulinas fueron: IgA &lt; 0,13, IgG &lt; 3 e IgM &lt; 0,25 g\/L. La biopsia de m\u00e9dula \u00f3sea revel\u00f3 un aumento del 80 % en el n\u00famero de c\u00e9lulas, sin alteraciones morfol\u00f3gicas. Se indicaron estudios complementarios para la agammaglobulinemia.<\/jats:p>","DOI":"10.7705\/biomedica.7524","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T15:50:52Z","timestamp":1736437852000},"page":"48-50","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Primera parte. Hombre de 45 a\u00f1os con neumon\u00eda grave, infecci\u00f3n diseminada por citomegalovirus y agammaglobulinemia","First part. A 45-year-old man with severe pneumonia, disseminated cytomegalovirus infection, and agammaglobulinemia"],"prefix":"10.7705","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-543X","authenticated-orcid":false,"given":"M\u00f3nica","family":"Fernandes Pineda","sequence":"first","affiliation":[{"name":"Departamento de Medicina Interna, Universidad del Valle, Cali, Colombia"},{"name":"Departamento de Medicina Interna, Universidad del Valle, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-3677","authenticated-orcid":false,"given":"Andr\u00e9s F.","family":"Zea-Vera","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Facultad de Salud, Universidad del Valle, Cali, Colombia; Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA"},{"name":"Departamento de Microbiolog\u00eda, Facultad de Salud, Universidad del Valle, Cali, Colombia; Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2024,12,23]]},"container-title":["Biom\u00e9dica"],"original-title":[],"link":[{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7524\/5638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7524\/5725","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7524\/5638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:15:54Z","timestamp":1773321354000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/view\/7524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":0,"journal-issue":{"issue":"Sp. 2","published-online":{"date-parts":[[2024,12,23]]}},"URL":"https:\/\/doi.org\/10.7705\/biomedica.7524","relation":{},"ISSN":["2590-7379","0120-4157"],"issn-type":[{"value":"2590-7379","type":"electronic"},{"value":"0120-4157","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"assertion":[{"value":"2024-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer Reviewed","group":{"name":"peer_review","label":"Peer Review"}},{"value":"Instituto Nacional de Salud","name":"publisher","label":"This article is maintained by"},{"value":"Biomedica","name":"journaltitle","label":"Journal Title"},{"value":"Haga usted el diagn\u00f3stico","name":"content_type","label":"Content Type"}]}}