{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T01:39:57Z","timestamp":1773365997490,"version":"3.50.1"},"reference-count":14,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"Sp. 2","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003402","name":"Fundaci\u00f3n Valle del Lili","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003402","name":"Fundaci\u00f3n Valle del Lili","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introducci\u00f3n. El s\u00edndrome hemofagoc\u00edtico es una condici\u00f3n poco reconocida, pero con gran mortalidad en la poblaci\u00f3n pedi\u00e1trica. Se caracteriza por la activaci\u00f3n excesiva de c\u00e9lulas inmunitarias y la liberaci\u00f3n de citocinas, lo cual causa inflamaci\u00f3n persistente. Puede ser primario o secundario, asociado con diversos factores.Objetivo. Describir 12 casos cl\u00ednicos de ni\u00f1os menores de cinco a\u00f1os con s\u00edndrome hemofagoc\u00edtico en una instituci\u00f3n de alta complejidad del suroccidente de Colombia.Materiales y m\u00e9todos. Se presenta una serie retrospectiva de 12 casos de s\u00edndrome hemofagoc\u00edtico en menores de cinco a\u00f1os en una instituci\u00f3n de alta complejidad de Colombia entre el 2019 y el 2022.Resultados. La mediana de la edad de los pacientes fue de un a\u00f1o, 7 eran de sexo masculino. La fiebre y la esplenomegalia fueron las manifestaciones cl\u00ednicas m\u00e1s comunes en 11 pacientes. Los hallazgos de laboratorio predominantes fueron: hiperferritinemia en 11 casos, hipertrigliceridemia en 10, bicitopenia en 6 y pancitopenia en 2. Se observ\u00f3 aumento de la lactato-deshidrogenasa en 11 casos. Siete pacientes se sometieron a estudios gen\u00e9ticos. En cuanto al tratamiento, el protocolo HLH-2004 completo se cumpli\u00f3 en 5 pacientes. Tres casos reportados en este trabajo recibieron trasplante de progenitores hematopoy\u00e9ticos. Tres pacientes fallecieron.Conclusi\u00f3n. Se resalta la complejidad del s\u00edndrome hemofagoc\u00edtico y, m\u00e1s a\u00fan, en ni\u00f1os menores de cinco a\u00f1os, ya que la baja prevalencia de la enfermedad y su presentaci\u00f3n cl\u00ednica inespec\u00edfica contribuyen al subdiagn\u00f3stico. Se destaca la importancia de considerar los factores desencadenantes, la evaluaci\u00f3n gen\u00e9tica para un diagn\u00f3stico preciso y temprano, la necesidad de un enfoque multidisciplinario y la consideraci\u00f3n oportuna del trasplante de progenitores hematopoy\u00e9ticos para mejorar la morbimortalidad.<\/jats:p>","DOI":"10.7705\/biomedica.7526","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T15:50:52Z","timestamp":1736437852000},"page":"140-154","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Un enemigo oculto: tratando de entender el s\u00edndrome hemofagoc\u00edtico en ni\u00f1os menores de 5 a\u00f1os en una instituci\u00f3n de alta complejidad del suroccidente de Colombia","A hidden enemy: Understanding the hemophagocytic syndrome in children under five years of age in a high-complexity institution in southwestern Colombia"],"prefix":"10.7705","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-0710","authenticated-orcid":false,"given":"Sof\u00eda","family":"Mart\u00ednez","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8295-3958","authenticated-orcid":false,"given":"Jacobo","family":"Trivi\u00f1o","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-2359","authenticated-orcid":false,"given":"Oriana","family":"Arias","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-7957","authenticated-orcid":false,"given":"Diego","family":"Medina","sequence":"additional","affiliation":[{"name":"Hemato-Oncolog\u00eda Pedi\u00e1trica, Departamento de Pediatr\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Hemato-Oncolog\u00eda Pedi\u00e1trica, Departamento de Pediatr\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3173-6059","authenticated-orcid":false,"given":"Alexis","family":"Franco","sequence":"additional","affiliation":[{"name":"Hemato-Oncolog\u00eda Pedi\u00e1trica, Departamento de Pediatr\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Hemato-Oncolog\u00eda Pedi\u00e1trica, Departamento de Pediatr\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1022-3606","authenticated-orcid":false,"given":"Jaime","family":"Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-3485","authenticated-orcid":false,"given":"Paola","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2672-0439","authenticated-orcid":false,"given":"Harry","family":"Pachajoa","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad ICESI, Cali, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad ICESI, Cali, 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